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Management of Drug-Resistant Epilepsy
Continuum, 2016This review discusses the definition, evaluation, and management of patients with drug-resistant epilepsy.Drug-resistant epilepsy is defined as a failure of two or more appropriately selected and adequately tried anticonvulsant medications to achieve seizure freedom for a sustained period of time in either monotherapy or polytherapy.
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Genetics of drug resistance in epilepsy
Current Neurology and Neuroscience Reports, 2005Drug resistance is a major clinical problem in epilepsy, affecting one in three patients. It is likely to have a complex multifactorial basis, with environmental and genetic contributions. Knowledge of robust genetic factors underlying drug resistance might both improve prediction and permit the development of novel rational treatments for resistance ...
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Focal Cooling for Drug-Resistant Epilepsy
JAMA Neurology, 2022Epilepsy affects at least 1.2% of the population, with one-third of cases considered to be drug-resistant epilepsy (DRE). For these cases, focal cooling therapy may be a potential avenue for treatment, offering hope to people with DRE for freedom from seizure.
Itamar, Niesvizky-Kogan +3 more
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Management of Epilepsy in Drug-Resistant Patients
CNS Spectrums, 2010Epilepsy affects > 2 million people in the United States, making it one of the most common neurobiological conditions. Typically, epilepsy is treated with one of several available antiepileptic drugs and patients are able to experience freedom from seizures with minimal side effects.
Brien J, Smith, Andrew J, Cole
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Connectome biomarkers of drug‐resistant epilepsy
Epilepsia, 2020AbstractDrug‐resistant epilepsy (DRE) considerably affects patient health, cognition, and well‐being, and disproportionally contributes to the overall burden of epilepsy. The most common DRE syndromes are temporal lobe epilepsy related to mesiotemporal sclerosis and extratemporal epilepsy related to cortical malformations.
Sara Larivière +3 more
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Identification and Treatment of Drug-Resistant Epilepsy
Continuum, 2019Drug-resistant epilepsy is a potentially life-threatening condition affecting one-third of people living with epilepsy. Despite existing evidence of improved outcomes in patients who received surgical treatment compared to continued medical treatment, epilepsy surgery remains underused in patients with drug-resistant epilepsy.
Ji Yeoun, Yoo, Fedor, Panov
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Neuromodulation in pediatric drug-resistant epilepsy
Epilepsy & BehaviorThis is a summary of the three commercially available neuromodulation devices for refractory epilepsy, highlighting their use in children. The article offers a high-level review of the proposed mechanisms of vagus nerve stimulation, responsive neurostimulation, and deep brain stimulation, the pivotal trials leading to their approval for use in the ...
Ann, Hyslop, Marytery, Fajardo
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Drug resistance in epilepsy: human epilepsy.
Novartis Foundation symposium, 2002The basis of drug resistance in human epilepsy is not understood. Parallels with resistance in cancer suggest that drug resistance proteins may have a role. To examine this possibility, we have studied human brain tissue containing pathologies capable of causing refractory epilepsy.
S M, Sisodiya +4 more
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Resective Epilepsy Surgery for Drug-Resistant Focal Epilepsy
JAMA, 2015Epilepsy surgery is indicated for patients with focal seizures who do not respond to appropriate antiepileptic drug therapy consisting of 2 or more medications.To review resective surgery outcomes for focal epilepsy, to identify which patients benefit the most, and to discuss why epilepsy surgery may not be universally accepted.Medline and Cochrane ...
Barbara C, Jobst, Gregory D, Cascino
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Neuromodulation for the Treatment of Drug-Resistant Epilepsy
2014Surgical neuromodulation for epilepsy refers to procedures involving the electrical stimulation of cortical, diencephalic, cerebellar and peripheral targets (such as the vagus nerve). Stereotactic radiosurgery also provides a neuromodulatory approach, affecting the discharging behavior of epileptic neurons in absence of evident target necrosis ...
Romanelli, Pantaleo, Conti, Alfredo
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