Results 201 to 210 of about 33,337 (262)

A translational multimodal machine‐learning prototype predicting valproate response in epilepsy treatment

Epilepsia, EarlyView.
Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte, Afsheen Kumar, Giorgia Guerini, Massimo Pandolfo, Denise Haslinger, Colin B. Josephson, Guillermo Delgado‐García, Navprabhjot Kaur, Michaela‐Pauline Lux, Heiko Stempfle, Chantal Depondt, Reetta Kälviäinen, Felix Rosenow, Sophie von Brauchitsch, Karl Martin Klein, Andreas G. Chiocchetti   +15 more
wiley   +1 more source

Nationwide Study of Pediatric Drug-Resistant Epilepsy in Estonia: Lower Incidence and Insights into Etiology. [PDF]

Pediatr Rep
Lilles S, Heidmets K, Oja KT, Reinson K, Roht L, Pajusalu S, Wojcik MH, Õunap K, Talvik I.   +8 more
europepmc   +1 more source

Cognitive and behavioral clinical outcome assessments in children with developmental and epileptic encephalopathies: Issues and instruments

Epilepsia, EarlyView.
Abstract Children with developmental and epileptic encephalopathies (DEEs) face cognitive and behavioral challenges that may have a greater impact than seizures on their quality of life (QoL). The need to assess these nonseizure outcomes for evaluating treatments is increasingly recognized.
Cinzia Correale, Nicola Specchio, Jenny Downs, J. Helen Cross, Simona Cappelletti, Andrea Palacio‐Navarro, Sam Geuens, Kette Valente, Andreas Brunklaus, Colin Reilly   +9 more
wiley   +1 more source

Drug resistant epilepsy driven by <i>RHEB</i> gene variants - Current evidence and a novel report of a paedatric case. [PDF]

Epilepsy Behav Rep
Esserlind AL, Pedersen A, Abel F, Hallbook T, Reilly C, Nilsson D, Liakina T, Bontell TO.   +7 more
europepmc   +1 more source

Long‐term prognosis of pharmacotherapy in newly diagnosed focal epilepsy patients and the predictive value of baseline seizure timing: A prospective cohort study

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a highly heterogeneous neurological disorder with significant prognostic variability. Accurate long‐term outcome prediction remains a clinical challenge. We investigated pharmacotherapeutic prognosis and key predictors, particularly baseline seizure timing, to guide individualized treatment.
Lei Sun, Shouye Sun, Xinyue Zhang, Weihong Lin   +3 more
wiley   +1 more source

Elucidating the putative role of cannabigerol: a hypothesis-generating review of neuroinflammatory and neuroprotective mechanisms with implications for drug-resistant epilepsy. [PDF]

Front Pharmacol
Patricio-Martínez A, Hernández-Percastegui S, Tzompantzi Juarez NT, Patricio F, Limón ID.   +4 more
europepmc   +1 more source

Predicting surgical outcome in drug-resistant epilepsy by combining interictal biomarkers within a machine learning framework. [PDF]

Sci Rep
Partamian H, Jahromi S, Perry MS, Hansen D, Bosemani M, Wang J, Tamilia E, Madsen JR, Bolton J, Stone SSD, Pearl PL, Papadelis C.   +11 more
europepmc   +1 more source

Clobazam in Adult Drug-Resistant Epilepsy: Excellent Long-Term Retention and Potential Synergy with Neuromodulation. [PDF]

Cureus
Fang B, Haroon M, Kalantzis E, Kurukumbi M.   +3 more
europepmc   +1 more source

Real-World Use of Cenobamate in Paediatric Drug-Resistant Epilepsy: Long-Term Efficacy, Safety, and Co-Medication Adjustment. [PDF]

Eur J Neurol
Pisano T, Pisano T, Balestrini S, Boncristiano A, Caini S, Lombardini M, Scuma E, Cavallin M, Bartolini L, Pellacani S, Barba C, Guerrini R.   +11 more
europepmc   +1 more source

Transcriptomic decoding of regional cortical vulnerability to drug-resistant epilepsy using 7T MRI. [PDF]

Commun Biol
Mao H, Matsubara T, Tanaka N, Peled N, Farzaneh H, Melania Lon D, Suzuki N, Richardson RM, Cole AJ, Fang X, Stufflebeam SM.   +10 more
europepmc   +1 more source