Results 211 to 220 of about 6,076,909 (260)

Decoupling topological and molecular features for interpretable biomolecular interaction prediction. [PDF]

Brief Bioinform
Wu Q, Liu Y, Yang F, Huang W, Zhu X, Liu J.   +5 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

End-to-End Intelligent Drug Discovery via a Scalable and Explainable Graph-Transformer Framework. [PDF]

Bioengineering (Basel)
Talaat FM, Elnakib A, Hekal AA, Alnaggar M, Abdellatif AG, Shawky MA, Safwat S, Shaban WM, Shehata M.   +8 more
europepmc   +1 more source

Single–Atom Iron Sites Enable Enhanced Arsenic Removal From Water Through Synergistic Adsorption–Oxidation

Advanced Science, EarlyView.
Single–atom iron anchored on nitrogen–doped porous biochar exhibited ultra–efficient performance, exceptional environmental resilience, and integrated adsorption–oxidation functionality. The multifunctional architecture of the support and the unparalleled reactivity of single–atom iron underpinned the cooperative adsorption and oxidation of As(III ...
Tao Sun, Chao Wang, Shihang Wu, Xiaojia Zhou, Penggang Pei, Huijuan Yu, Yun Zhang, Qingqing Huang, Yuebing Sun   +8 more
wiley   +1 more source

An interpretable framework applying protein words to predict protein-small molecule complementary pairing rules. [PDF]

Chem Sci
Chen J, Zhong J, Tani TH, Su Z, Zhang X, Tian B.   +5 more
europepmc   +1 more source

Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis

Advanced Science, EarlyView.
A schematic model summarizing GNA15's mechanism in mediating macrophage M2 polarization and Gemcitabine resistance. ABSTRACT The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune ...
Weihui Guo, Zhenyuan Qian, Lei Wang, Weilang Xu, Yuxin Weng, Kai Jiang, Zaiyuan Ye, Ji Xu, Guangyuan Song   +8 more
wiley   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

LNMGAT: a laplacian regularized pseudo-negative mining graph attention network for robust drug-target interaction prediction under multi-scenario cold-start settings. [PDF]

Front Bioinform
Guo S, Liu W, Zou J, Ban T, Dong G.
europepmc   +1 more source

Antibody-drug conjugate engineering: from design to efficacy and safety. [PDF]

Signal Transduct Target Ther
Ocana A, Espinosa JR, Alonso-Moreno C, Győrffy B, Tong H, Pandiella A.   +5 more
europepmc   +1 more source

BoltzOmics: Predicting genetic variant effects on drug binding with Boltz-2. [PDF]

iScience
Ngo K, Carraway KL, Clancy CE, Amini H.
europepmc   +1 more source