Results 31 to 40 of about 8,194,451 (253)

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Villemaine Estelle, Brendan D Galvin, Wyatt, Paul G., Zhiru Li, Estelle Villemaine, Brendan D. Galvin (592211), Carlow, Clotilde K. S., Wyatt Paul G., Zhiru Li (295010), Poole Catherine B., Li, Zhiru, Carlow Clotilde K. S., Michael P. Pollastri (345704), Clotilde K S Carlow, Michael P Pollastri, Li Zhiru, Chapman Melissa S., Melissa S. Chapman (625936), Melissa S Chapman, Chapman, Melissa S., Pollastri, Michael P., Clotilde K. S. Carlow (111245), Catherine B. Poole (111223), Paul G. Wyatt (473658), Pollastri Michael P., Poole, Catherine B., Catherine B Poole, Galvin, Brendan D., Villemaine, Estelle, Paul G Wyatt, Galvin Brendan D., Estelle Villemaine (625935)   +31 more
core   +2 more sources

Local and global modes of drug action in biochemical networks [PDF]

, 2008
It becomes increasingly accepted that a shift is needed from the traditional target-based approach of drug development to an integrated perspective of drug action in biochemical systems. We here present an integrative analysis of the interactions between
Schwartz, Jean Marc; id_orcid, Jean-Marc Schwartz, Nacher, Jose C., Jose C. Nacher, Jose C Nacher   +4 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]

, 2014
This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
core  

Emerging paradigms in anti-infective drug design. [PDF]

, 2014
The need for new drugs to treat microbial infections is pressing. The great progress made in the middle part of the twentieth Century was followed by a period of relative inactivity as the medical needs relating to infectious disease in the wealthier ...
Croft, Simon L, Barrett, Michael P., Barrett, Michael P, Croft, Simon L.   +3 more
core   +1 more source

Drug–target interaction prediction using knowledge graph embedding

iScience
Summary: The prediction of drug-target interactions (DTIs) is a critical phase in the sustainable drug development process, especially when the research focus is to capitalize on the repositioning of existing drugs. Computational approaches to predicting
Nan Li, Zhihao Yang, Jian Wang, Hongfei Lin   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Warfarin - Sulfamethoxazole-trimethoprim - contextualized potential drug-drug interaction clinical algorithm

, 2018
An algorithm developed for research purposes that summarizes the potential drug-drug interaction between Warfarin - Sulfamethoxazole-trimethoprim. The information is not advice, and should not be treated as such.
Contributors to the A Minimum Representation of Potential Drug-Drug Interaction Knowledge and Evidence - Technical and User-centered Foundation Specification
core   +1 more source

Drug-Target Interaction Prediction Based on Drug Fingerprint Information and Protein Sequence

Molecules, 2019
The identification of drug-target interactions (DTIs) is a critical step in drug development. Experimental methods that are based on clinical trials to discover DTIs are time-consuming, expensive, and challenging.
Yang Li, Yu-An Huang, Zhu-Hong You, Li-Ping Li, Zheng Wang   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source