Results 41 to 50 of about 888,632 (296)

DTiGEMS+: drug-target interaction prediction using graph embedding, graph mining, and similarity-based techniques.

, 2019
In silico prediction of drug-target interactions is a critical phase in the sustainable drug development process, especially when the research focus is to capitalize on the repositioning of existing drugs.
Olayan, Rawan S, Gao, Xin, Ashoor, Haitham, Thafar, Maha A., Albaradei, Somayah, Bajic, Vladimir B, Bajic, Vladimir B., Thafar, Maha A, Olayan, Rawan S., Gojobori, Takashi, Essack, Magbubah   +10 more
core   +1 more source

Exploring complex and heterogeneous correlations on hypergraph for the prediction of drug-target interactions

, 2021
The continuous emergence of drug-target interaction data provides an opportunity to construct a biological network for systematically discovering unknown interactions.
Yan, C, Dai, Q, Gao, Y, Ji, S, Zou, C, Zhao, X, Yang, Y, Zhu, J, Ruan, D   +8 more
core   +1 more source

Challenges and solutions in drug-target interaction prediction [PDF]

, 2020
When a drug is developed, it is designed so that it interacts with a specific target of interest in order to achieve the desired therapeutic effect. However, it is quite common to later find that the developed drug also interacts with multiple other targets that were not intended during its development.
openaire   +2 more sources

Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]

, 2014
A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core   +1 more source

Warfarin - Sulfamethoxazole-trimethoprim - contextualized potential drug-drug interaction clinical algorithm

, 2018
An algorithm developed for research purposes that summarizes the potential drug-drug interaction between Warfarin - Sulfamethoxazole-trimethoprim. The information is not advice, and should not be treated as such.
Contributors to the A Minimum Representation of Potential Drug-Drug Interaction Knowledge and Evidence - Technical and User-centered Foundation Specification
core   +1 more source

Tamoxifen-Paroxetine - contextualized potential drug-drug interaction clinical algorithm

, 2018
An algorithm developed for research purposes that summarizes the potential drug-drug interaction between tamoxifen and paroxetine. The information is not advice, and should not be treated as such.
Contributors to the A Minimum Representation of Potential Drug-Drug Interaction Knowledge and Evidence - Technical and User-centered Foundation Specification
core   +1 more source

Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing [PDF]

, 2022
Knowledge of the full target space of drugs (or drug-like compounds) provides important insights into the potential therapeutic use of the agents to modulate or avoid their various on- and off-targets in drug discovery and precision medicine.
Alam Zaid, Ianevski Aleksandr, Aittokallio Tero, Tanoli Ziaurrehman, Vähä-Koskela Markus, Wennerberg Krister   +5 more
core   +1 more source

Drug–target interaction prediction using knowledge graph embedding

iScience
Summary: The prediction of drug-target interactions (DTIs) is a critical phase in the sustainable drug development process, especially when the research focus is to capitalize on the repositioning of existing drugs. Computational approaches to predicting
Nan Li, Zhihao Yang, Jian Wang, Hongfei Lin   +3 more
doaj   +1 more source

Amiodarone - Simvastatin - contextualized potential drug-drug interaction clinical algorithm

, 2018
An algorithm developed for research purposes that summarizes the potential drug-drug interaction between amiodarone and simvastatin. The information is not advice, and should not be treated as such.
Contributors to the A Minimum Representation of Potential Drug-Drug Interaction Knowledge and Evidence - Technical and User-centered Foundation Specification
core   +1 more source

Drug-target interaction prediction using Multi Graph Regularized Nuclear Norm Minimization

, 2020
The identification of potential interactions between drugs and target proteins is crucial in pharmaceutical sciences. The experimental validation of interactions in genomic drug discovery is laborious and expensive; hence, there is a need for efficient ...
Angshul Majumdar (6271007), Aanchal Mongia (6271001), Aanchal Mongia, Angshul Majumdar   +3 more
core   +1 more source