Results 91 to 100 of about 6,956,165 (310)
FEBS Letters, EarlyView.Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston +7 more
wiley +1 more source
Drug Cases Filed across the Alaska Court System, FY 2008–2017 [PDF]
, 2018 Underlying data is available in both Excel and PDF format. (Download below.)This fact sheet presents data on drug-related court filings throughout the state of Alaska for the fiscal years (FY) 2008 through 2017 and the 10-year trend of misdemeanor and ...
Reinhard, Daniel
core
Representation learning of drug and disease terms for drug repositioning
, 2017 Drug repositioning (DR) refers to identification of novel indications for the approved drugs. The requirement of huge investment of time as well as money and risk of failure in clinical trials have led to surge in interest in drug repositioning.
Anand, Ashish, Manchanda, Sahil
core +1 more source
Drug effectiveness or drug toxicity?
La Pediatria Medica e Chirurgica, 2012 Not ...
openaire +5 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]
This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
core
Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing [PDF]
, 2019 Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery.
Baldwin, Nicole E. +4 more
core +1 more source
Drug Recommendation toward Safe Polypharmacy [PDF]
arXiv, 2018 Adverse drug reactions (ADRs) induced from high-order drug-drug interactions (DDIs) due to polypharmacy represent a significant public health problem. In this paper, we formally formulate the to-avoid and safe (with respect to ADRs) drug recommendation problems when multiple drugs have been taken simultaneously.
arxiv
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Market Analysis of Synthetic Drugs: Amphetamine-type Stimulants, New Psychoactive Substances [PDF]
, 2017 An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...
core