Results 51 to 60 of about 6,956,165 (310)

Renal drug transporters and their significance in drug–drug interactions

Acta Pharmaceutica Sinica B, 2016
The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molecules in the kidney.
Jia Yin, Joanne Wang
openaire   +4 more sources

Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders

Frontiers in Genetics, 2019
The field of gene therapy is striving more than ever to define a path to the clinic and the market. Twenty gene therapy products have already been approved and over two thousand human gene therapy clinical trials have been reported worldwide.
Alireza Shahryari, Alireza Shahryari, Alireza Shahryari, Alireza Shahryari, Marie Saghaeian Jazi, Marie Saghaeian Jazi, Saeed Mohammadi, Hadi Razavi Nikoo, Zahra Nazari, Elaheh Sadat Hosseini, Ingo Burtscher, Ingo Burtscher, Seyed Javad Mowla, Heiko Lickert, Heiko Lickert   +14 more
doaj   +1 more source

Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation

mBio, 2020
New antimalarial drugs are needed. The benzoxaborole AN13762 showed excellent activity against cultured Plasmodium falciparum, against fresh Ugandan P. falciparum isolates, and in murine malaria models.
Kirthana M. V. Sindhe, Wesley Wu, Jenny Legac, Yong-Kang Zhang, Eric E. Easom, Roland A. Cooper, Jacob J. Plattner, Yvonne R. Freund, Joseph L. DeRisi, Philip J. Rosenthal   +9 more
doaj   +1 more source

Drug-target affinity prediction method based on consistent expression of heterogeneous data [PDF]

arXiv, 2022
The first step in drug discovery is finding drug molecule moieties with medicinal activity against specific targets. Therefore, it is crucial to investigate the interaction between drug-target proteins and small chemical molecules. However, traditional experimental methods for discovering potential small drug molecules are labor-intensive and time ...
arxiv  

Drug Management Reviews in District Drug Management Unit and General Hospital [PDF]

, 2009
Drug is one of the essential elements in healthcare that should be effectively and efficiently managed. Following the decentralization in 2001 in Indonesia, drug management has changed in district drug management units and also in District General ...
Handayani, R. S. (Rini), Herman, M. J. (Max), Yuniar, Y. (Yuyun)   +2 more
core  

Microfluidics for Advanced Drug Delivery Systems. [PDF]

, 2015
Considerable efforts have been devoted towards developing effective drug delivery methods. Microfluidic systems, with their capability for precise handling and transport of small liquid quantities, have emerged as a promising platform for designing ...
Dokmeci, Mehmet R, Ghaemmaghami, Amir, Khademshosseini, Ali, Riahi, Reza, Shaegh, Seyed Ali Mousavi, Tamayol, Ali   +5 more
core   +1 more source

Drug-drug interactions with raltegravir

European Journal of Medical Research, 2009
To review all currently published drug-drug interaction studies with the HIV-integrase inhibitor raltegravir.A PubMed search was conducted for all published reports up to August 1, 2009 as well as a review of updated European and US Prescriber's Information (EMEA and FDA) and abstracts from recent international scientific meetings.A total of 14 drug ...
openaire   +5 more sources

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

Frontiers in Neurology, 2015
There currently is no therapeutic drug treatment for traumatic brain injury (TBI) despite decades of experimental clinical trials. This may be because the mechanistic pathways for improving TBI outcomes have yet to be identified and exploited. As such,
Gregory eHook, J. Steven Jacobsen, Kenneth eGrabstein, Mark eKindy, Mark eKindy, Vivian eHook   +5 more
doaj   +1 more source

Drug Interactions in Iranian Veterans With Chronic Spinal Cord Injury - A Descriptive Study

International Clinical Neuroscience Journal, 2020
Background: Veterans with chronic spinal cord injury usually have various comorbidities. They are, therefore, visited by different doctors and use different medications. It is necessary to monitor the health of these veterans. One of the important issues
Ashkan Divanbeigi, Amir Saied Seddighi, Sepideh Amiri, Shiva Jamshidi, Hesam Rahimi Baghdashti, Afsoon Seddighi   +5 more
doaj   +1 more source

Drug prescription clusters in the UK Biobank: An assessment of drug-drug interactions and patient outcomes in a large patient cohort [PDF]

arXiv, 2022
In recent decades, there has been an increase in polypharmacy, the concurrent administration of multiple drugs per patient. Studies have shown that polypharmacy is linked to adverse patient outcomes and there is interest in elucidating the exact causes behind this observation.
arxiv