Results 51 to 60 of about 8,662,910 (358)
Immune responses in fatalities involving opioids
Forensic Sciences Research, 2019 In some cases of fatalities involving opioid use, the concentrations of detected opioids are not in the toxic range. Immune reactions can be triggered by opioid use, suggesting that immune response may be a factor in these cases.
Henry J. Carson
doaj +1 more source
Market Analysis of Synthetic Drugs: Amphetamine-type Stimulants, New Psychoactive Substances [PDF]
, 2017 An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...
core
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
FUNCTIONAL ANALYSIS OF THE WEBBING USED IN AUTO SEATBELTS [PDF]
Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2016 The reason this paper was made was to identify the functions with the highest importance factor of webbing used in auto seatbelts. For these functions to satisfy all the requirements of operating, functions resulted from analyzing the properties of the ...
DRUG (LUCA) Alexandra, CIOARĂ Ioan
doaj
The Pan African Medical Journal, 2011 INTRODUCTION: Pharmaceutical drug promotion is a means of informing health professionals about new drugs. The approach is often times unethical and inappropriate and may promote irrational prescription.
Kazeem Adeola Oshikoya +2 more
doaj +1 more source
Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing [PDF]
, 2019 Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery.
Baldwin, Nicole E. +4 more
core +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Beginning and development of the abuse and illegal traffic of drugs in Kosovo and Metohia [PDF]
Baština, 2013 Drug addiction (toxicomany) became a global social, psycho-medical, and political-legal problem of the 70-ies of the 20th century. At the end of the 20th and at the beginning of the 21st century this pandemy, white plague, is beginning an important ...
Beriša Hatidža
doaj
Mechanisms of burst release from pH-responsive polymeric microparticles. [PDF]
, 2011 Microencapsulation of drugs into preformed polymers is commonly achieved through solvent evaporation techniques or spray drying. We compared these encapsulation methods in terms of controlled drug release properties of the prepared microparticles and ...
Donaldson, M +4 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source