Results 91 to 100 of about 962,829 (360)

A Fifty-year challenge in managing drug addiction in Malaysia [PDF]

, 2008
The history of substance abuse in Malaysia can be divided into pre- and post-independent era. In pre-independence, the main drug of abuse was opium which was initially consumed by immigrants from China who were introduced by the British ...
Habil, Mohamad Hussain, Robson , Noorzurani, Rusdi , Abd Rashid, Zahari , Muhammad Muhsin Ahad   +3 more
core   +1 more source

Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks

Nature Communications
Outcome-guided behavior requires knowledge about the identity of future rewards. Previous work across species has shown that the dopaminergic midbrain responds to violations in expected reward identity and that the lateral orbitofrontal cortex (OFC ...
Qingfang Liu, Yao Zhao, Sumedha Attanti, Joel L. Voss, Geoffrey Schoenbaum, Thorsten Kahnt   +5 more
doaj   +1 more source

Central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine

Frontiers in Neuroscience, 2015
The pattern of neural, physiological and behavioral effects induced by cocaine is consistent with metabolic neural activation, yet direct attempts to evaluate central metabolic effects of this drug have produced controversial results.
Ken Taro Wakabayashi, Eugene A Kiyatkin
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Sentencing Reform for Nonviolent Offenses: Benefits and Estimated Savings for Illinois [PDF]

, 2004
Commissioned by the Developing Justice Coalition, this report examines alternatives to incarceration for nonviolent drug offenses. The report discusses the potential cost savings and the social benefits of sentencing nonviolent drug offenders to mandated
Lise McKean, Susan K. Shapiro
core  

Geospatial Clustering Analysis on Drug Abuse Emergencies

, 2022
Jinha Lee, Jung Im Choi, Arthur B. Yeh, Qizhen Lan, Hyojung Kang   +4 more
openalex   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide [PDF]

, 2012
Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This
Zhao, Fang
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

An Immortalized Rat Ventral Mesencephalic Cell Line, RTC4, Is Protective in a Rodent Model of Stroke

Cell Transplantation, 2007
One therapeutic approach to stroke is the transplantation of cells capable of trophic support, reinnervation, and/or regeneration. Previously, we have described the use of novel truncated isoforms of SV40 large T antigen to generate unique cell lines ...
B. K. Harvey, G. J. Chen, C. J. Schoen, C. T. Lee, D. B. Howard, O. Dillon-Carter, M. Coggiano, W. J. Freed, Y. Wang, B. J. Hoffer, J. F. Sanchez   +10 more
doaj   +1 more source