Results 101 to 110 of about 2,545,292 (301)

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

IMPACT OF THE GHRELIN SYSTEM ON OXYCODONE-MOTIVATED BEHAVIORS STUDIED IN WISTAR RATS: SEX DIFFERENCES AND THE EFFECTS OF GHRELIN RECEPTOR DELETION AND ANTAGONISM

IBRO Neuroscience Reports, 2023
Ansh Agarwal, Zhi-Bing You, Sruti Pari, Madeline Crissman, Guo-Hua Bi, Lorenzo Leggio, Eliot Gardner   +6 more
doaj   +1 more source

GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice

Translational Psychiatry
G protein-coupled receptor 55 (GPR55) has been thought to be a putative cannabinoid receptor. However, little is known about its functional role in cannabinoid action and substance use disorders.
Yi He, Hui Shen, Guo-Hua Bi, Hai-Ying Zhang, Omar Soler-Cedeño, Hannah Alton, Yihong Yang, Zheng-Xiong Xi   +7 more
doaj   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

The ABCD Study at 10: The NIH perspective on progress, impact, and the road ahead

Developmental Cognitive Neuroscience
The Adolescent Brain Cognitive Development SM (ABCD) Study is a landmark study of nearly 12,000 U.S. youth from ages 9–10 through their second decade of life.
Nora D. Volkow, George F. Koob, William M. Klein, Jennifer A. Hobin, Eric M. Wargo, Diana Alkire, Elizabeth A. Hoffman, Susan R.B. Weiss, Gayathri J. Dowling   +8 more
doaj   +1 more source

2001 National Rural Institute On Alcohol and Drug Abuse Mailer

, 2001
Mailer containing information and a registration form for the 2001 National Rural Institute On Alcohol and Drug Abuse at the UW-Stout Memorial Student ...
National Rural Alcohol and Drug Abuse Network
core  

NewView [PDF]

, 1991
Newsletter of the Texas Commission on Alcohol and Drug Abuse providing updates the agency and their programs along with news, events, and other information related to addiction prevention and ...
Britcher, Bill, Texas Commission on Alcohol and Drug Abuse   +1 more
core  

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source