Results 111 to 120 of about 323,640 (268)

Addictive drug abuse and depression-a focus on epigenetics. [PDF]

Commun Biol
Zhang W, Xu M, Wang C, Liang H, Zhu X, Pan Y, Guo F.   +6 more
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Development and Pilot Evaluation of a Drug Abuse Prevention Program for Elementary School Children in Korea. [PDF]

Psychiatry Investig
Lee J, Yang J, Lee A, Ko Y, Shim JK, Lee SI.   +5 more
europepmc   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

The correlation between drug abuse belief, refusal of self-efficacy and drug craving of patients in the treatment of methadone replacement treatment. [PDF]

Front Psychol
Cai J, Dong H, Jin TY.
europepmc   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

The community representative council of the National Drug Abuse Treatment Clinical Trials Network: Co-design and early impact. [PDF]

J Subst Use Addict Treat
Moore SK, McLeman B, Saunders EC, Chapman SH, Marsch LA, Ackerson B, Cowan A, Doss DP, Filion S, Fowler R, Fox L, Gary J, Hamilton J, Jones R, Jordan A, Kibben R, Lamont M, Lawdahl T, Martin J, Pee J, Potter J, Peavy M, Ross TB, Scott D, Suarez E, Vest N, Vo H, Rosa C.   +27 more
europepmc   +1 more source

Drug Abuse. Leading to Drug Abuse

Environmental Health Perspectives, 2001
openaire   +1 more source

Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics

Advanced Science, EarlyView.
This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka, Bushra Raahat, Spyros Tragoudas, Hui Li   +3 more
wiley   +1 more source

Association between adverse childhood experiences and over-the-counter drug abuse in Japan: A nationwide population-based cross-sectional study. [PDF]

PCN Rep
Mori Y, Yoshioka T, Shishido R, Hino M, Sato A, Nagaoka A, Hatano M, Hosogai Y, Miyahara K, Tabuchi T, Miura I, Kunii Y.   +11 more
europepmc   +1 more source