Results 111 to 120 of about 315,545 (267)

The community representative council of the National Drug Abuse Treatment Clinical Trials Network: Co-design and early impact. [PDF]

J Subst Use Addict Treat
Moore SK, McLeman B, Saunders EC, Chapman SH, Marsch LA, Ackerson B, Cowan A, Doss DP, Filion S, Fowler R, Fox L, Gary J, Hamilton J, Jones R, Jordan A, Kibben R, Lamont M, Lawdahl T, Martin J, Pee J, Potter J, Peavy M, Ross TB, Scott D, Suarez E, Vest N, Vo H, Rosa C.   +27 more
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

fMRI reveals changes in basal metabolism induced by daily high-density TBS (hdTBS) for five days focally delivered to naïve rats

Brain Stimulation
Hanbing Lu, Qiong Li, Samantha Hoffman, Aidan Carney, Ying Duan, Zilu Ma, Nanyin Zhang, Yihong Yang   +7 more
doaj   +1 more source

Association between adverse childhood experiences and over-the-counter drug abuse in Japan: A nationwide population-based cross-sectional study. [PDF]

PCN Rep
Mori Y, Yoshioka T, Shishido R, Hino M, Sato A, Nagaoka A, Hatano M, Hosogai Y, Miyahara K, Tabuchi T, Miura I, Kunii Y.   +11 more
europepmc   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

Initiating a Life Skills Module to Prevent Drug Abuse Among Indonesian Adolescents Using Social Cognitive Theory [Letter]. [PDF]

J Multidiscip Healthc
Bai X.
europepmc   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Assessing personality profile: A qualitative study from drug abuse rehabilitation policies. [PDF]

MethodsX
Purwandari E, Japar M, Asyanti S, Giri RS, Yuliatun I, Madyaningrum E, Widyarini N.   +6 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

Advanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang, Xiangyang Zhan, Jiexiang Zhang, Mingyue Tan, Chuanmin Chu, Guanqun Ju, Xinyu Zhai, Jianyi Gu, Huirong Zhu, Dongliang Xu   +9 more
wiley   +1 more source