Results 151 to 160 of about 962,829 (360)

DEA Briefs & Background, Drugs and Drug Abuse, State Factsheets, West Virginia

, 2004
US Department of Justice; Drug Enforcement Administration
openalex   +1 more source

Addiction Enabling Doctors-- So You Want To Stop The Heroin And Drug Abuse Epidemic? [PDF]

, 2015
Samuel A Nigro
openalex   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

CLONIDINE INHIBITS OXYCODONE-MOTIVATED BEHAVIORS, BRAIN STIMULATION REWARD AND POTENTIATES THE ANTINOCICEPTIVE EFFECTS OF OXYCODONE IN RODENTS

IBRO Neuroscience Reports, 2023
Ashton Taylor, Madeline Crissman, Sruti Pari, Tristram Buck, Allamar Moore, Zhi-Bing You, Eliot Gardner, Guo-Hua Bi, Glenn Treisman   +8 more
doaj   +1 more source

Review of: "Factors Influencing Youth Drug Abuse: A Review Study" [PDF]

, 2023
I. L. A. N. Darshana
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Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

LATERAL HYPOTHALAMIC GLUTAMATERGIC INPUTS TO VTA GLUTAMATERGIC NEURONS MEDIATE PRIORITIZATION OF INNATE DEFENSIVE BEHAVIOR OVER FEEDING

IBRO Neuroscience Reports, 2023
M. Flavia Barbano, Shiliang Zhang, Emma Chen, Orlando Espinoza, Uzma Mohammad, Yocasta Alvarez-Bagnarol, Bing Liu, Marisela Morales   +7 more
doaj   +1 more source

Pharmacoepidemiologic Research on Drugs of Abuse

, 2019
Jana McAninch, Alex Secora, Cynthia Kornegay, Judy A. Staffa   +3 more
openalex   +1 more source

Multifactor Risk Stratification for Post‐Transplant Alcohol Relapse Using Abstinence, Psychosocial, and Socioeconomic Factors

Annals of Gastroenterological Surgery, EarlyView.
Alcohol relapse after liver transplantation is difficult to predict using abstinence duration alone. We developed a multifactor model integrating abstinence duration, psychosocial risk (SIPAT), and socioeconomic context (AUC 0.70). This approach may support individualized risk assessment and tailored follow‐up intensity; external validation is needed ...
Ayato Obana, Garren Montgomery, Miho Akabane, Matthew Hamilton, Navdeep Singh, Musab Alebrahim, Austin Schenk, Sylvester Black, Kenneth Washburn, Khalid Mumtaz   +9 more
wiley   +1 more source