Results 141 to 150 of about 957,503 (357)

RDS-04-010: a novel atypical DAT inhibitor that inhibits cocaine taking and seeking and itself has low abuse potential in experimental animals

Translational Psychiatry
Cocaine use disorder (CUD) is a severe public health problem, and currently, there is no FDA-approved medication for its treatment. Atypical dopamine (DA) transporter (DAT) inhibitors display low addictive liability by themselves and may have therapeutic
Omar Soler-Cedeno, Ewa Galaj, Benjamin Klein, Jianjing Cao, Guo-Hua Bi, Amy Hauck Newman, Zheng-Xiong Xi   +6 more
doaj   +1 more source

Drugs and Crime in Anchorage, Alaska: A Note [PDF]

, 2005
Also published in Alaska Justice Forum 22(1): 7 (Spring 2005).This research note examines the relationship between drug use and offense charged through data collected in 2003 from 259 recent arrestees in Anchorage, Alaska using the Arrestee Drug Abuse ...
Langworthy, Robert H., McKelvie, Alan R.
core  

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source

The Economics of Crime: Investigating the Drugs-Crime Channel [PDF]

The rising trends both in drug addiction and crime rates are of major public concern in Germany. Surprisingly, the economic theory of crime seems to ignore the drugs-crime nexus, whereas the criminological literature considers illicit drug use a main ...
Entorf, Horst, Winker, Peter
core  

Review of: "Factors Influencing Youth Drug Abuse: A Review Study" [PDF]

, 2023
I. L. A. N. Darshana
openalex   +1 more source

Distinct Biotypes of Visual Perception in Major Depressive Disorder

Advanced Science, EarlyView.
In a discover dataset (272 acute MDD patients), this work identifies a novel depression biotype characterized by impaired visual motion perception, using machine learning clustering. An independent dataset confirms the robustness of this biotype through cross‐validation and demonstrates its generalizability.
Zhuoran Cai, Xi‐Wen Hu, Yuyang Li, Zheng Lin, Yongjie Li, Yong‐Chun Cai, Tao Xu, Ke Jia, Jin‐Fang Han, Zhong‐Lin Tan, Dezhong Yao, Xue Mei Song, Sugai Liang, Georg Northoff   +13 more
wiley   +1 more source

Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation

Advanced Science, EarlyView.
Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li, Yue Wang, Xiufang Liang, Mengze Xu, David T. Leong, Pu Chun Ke   +5 more
wiley   +1 more source

CLONIDINE INHIBITS OXYCODONE-MOTIVATED BEHAVIORS, BRAIN STIMULATION REWARD AND POTENTIATES THE ANTINOCICEPTIVE EFFECTS OF OXYCODONE IN RODENTS

IBRO Neuroscience Reports, 2023
Ashton Taylor, Madeline Crissman, Sruti Pari, Tristram Buck, Allamar Moore, Zhi-Bing You, Eliot Gardner, Guo-Hua Bi, Glenn Treisman   +8 more
doaj   +1 more source

Pulicaria gnaphalodes-assisted green synthesis of NiFe2O4@ZnO nanocomposites for sustainable remediation of an antibiotic from aqueous solution

Applied Water Science
In this study, the NiFe2O4@ZnO nanocomposite was synthesized in a simple, accessible and affordable method using Pulicaria gnaphalodes plant extract as a reducing agent. The structural characteristics of this nanocomposite were determined by transmission
Elham Derakhshani, Ali Naghizadeh, Sobhan Mortazavi-Derazkola, Ali Yousefinia   +3 more
doaj   +1 more source

DEA Briefs & Background, Drugs and Drug Abuse, State Factsheets, West Virginia

, 2004
US Department of Justice; Drug Enforcement Administration
openalex   +1 more source