Results 31 to 40 of about 932,717 (306)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Scientific ReportsMicroglia are the resident immune cells of the central nervous system (CNS) and display diverse functions under both physiological and pathological conditions.
Elliot J. Glotfelty +14 more
doaj +1 more source
Parental perceptions of neighborhood effects in Latino comunas: the script of "the delinquent" in understanding drug use, violence, and social disorganization [PDF]
, 2012 OBJECTIVES: To obtain rich information about how adult Latinos living in high-poverty/high-drug use neighborhoods perceive and negotiate their environment.
Castillo, Marcela +3 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Cortico-amygdala coupling as a marker of early relapse risk in cocaine-addicted individuals
Frontiers in Psychiatry, 2014 Addiction to cocaine is a chronic condition characterized by high rates of early relapse. This study builds on efforts to identify neural markers of relapse risk by studying resting state functional connectivity (rsFC) in neural circuits arising from the
Meredith J Mchugh +6 more
doaj +1 more source
The NIDA clinical trials network: evolving, expanding, and addressing the opioid epidemic
Addiction Science & Clinical Practice, 2021 Over the past two decades, the National Drug Abuse Treatment Clinical Trials Network (CTN), a program of the National Institute on Drug Abuse (NIDA), has expanded from the initial six Nodes to 16 Nodes, as a nationwide consortium of research scientists ...
Betty Tai +4 more
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who agreed were followed up for at least 24 weeks.
Peiyu Wang +7 more
wiley +1 more source
A study on the perception of the stigma related to drug use in a sample of Italians and Belgians [PDF]
Psychology, Society & Education, 2015 The goal of the present study has been to exploratorily analyse the possible differences in perceived stigma on drug use between a sample of students and health services workers from Italy and Belgium.
Giuseppe Antonio Sciol +5 more
doaj
Molecular Medicine, 2016 The Cadherin 13 (CDH13) gene encodes a cell adhesion molecule likely to influence development and connections of brain circuits that modulate addiction, locomotion and cognition, including those that involve midbrain dopamine neurons.
Jana Drgonova +14 more
doaj +1 more source