Results 11 to 20 of about 323,640 (268)

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor

Nature Communications, 2018
D1-like dopamine receptors are coupled to Golf proteins in the dorsal striatum but Gs in cortical and other areas. Here, the authors demonstrate selective agonism of Gs-coupled versus Golf-coupled D1 receptors.
Hideaki Yano, Ning-Sheng Cai, Min Xu, Ravi Kumar Verma, William Rea, Alexander F. Hoffman, Lei Shi, Jonathan A. Javitch, Antonello Bonci, Sergi Ferré   +9 more
doaj   +1 more source

Phasic excitation of ventral tegmental dopamine neurons potentiates the initiation of conditioned approach behavior: Parametric and reinforcement-schedule analyses

Frontiers in Behavioral Neuroscience, 2014
Midbrain dopamine neurons are implicated in motivation and learning. However, it is unclear how phasic excitation of dopamine neurons, which is implicated in learning, is involved in motivation.
Anton eIlango, Andrew J. Kesner, Carl J. Broker, Dong V. Wang, Satoshi eIkemoto   +4 more
doaj   +1 more source

Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior

Translational Psychiatry, 2021
Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown.
Juan L. Gomez, Jordi Bonaventura, Jacqueline Keighron, Kelsey M. Wright, Dondre L. Marable, Lionel A. Rodriguez, Sherry Lam, Meghan L. Carlton, Randall J. Ellis, Chloe J. Jordan, Guo-hua Bi, Oscar Solis, Marco Pignatelli, Michael J. Bannon, Zheng-Xiong Xi, Gianluigi Tanda, Michael Michaelides   +16 more
doaj   +1 more source

Functional Connectivity Hubs and Networks in the Awake Marmoset Brain

Frontiers in Integrative Neuroscience, 2016
In combination with advances in analytical methods, resting-state fMRI is allowing unprecedented access to achieve a better understanding of the network organization of the brain. Increasing evidence suggests that this architecture may incorporate highly
Annabelle Marie Belcher, Annabelle Marie Belcher, Cecil Chern-Chyi Yen, Lucia eNotardonato, Thomas J. Ross, Nora D. Volkow, Nora D. Volkow, Yihong eYang, Elliot A. Stein, Afonso C Silva, Dardo eTomasi   +10 more
doaj   +1 more source

Robust brain hyperglycemia during general anesthesia: relationships with metabolic brain inhibition and vasodilation

Frontiers in Physiology, 2016
Glucose is the main energetic substrate for the metabolic activity of brain cells and its proper delivery into the extracellular space is essential for maintaining normal neural functions.
R. Aaron eBola, Eugene A Kiyatkin
doaj   +1 more source

Language models in digital psychiatry: challenges with simplification of healthcare materials

NPP-Digital Psychiatry and Neuroscience
Linguistic hurdles in healthcare, such as complex language, significantly affect patient outcomes, including satisfaction with interaction, comprehension of healthcare materials, and engagement with the healthcare system.
Ankit Aich, Tingting Liu, Salvatore Giorgi, Kelsey Isman, Ruhshana Bobojonova, Lyle Ungar, Brenda Curtis   +6 more
doaj   +1 more source

Behavior-associated and post-consumption glucose entry into the nucleus accumbens extracellular space during glucose free-drinking in trained rats

Frontiers in Behavioral Neuroscience, 2015
Glucose is the primary energetic substrate for the metabolic activity of brain cells and its proper delivery from the arterial blood is essential for neural activity and normal brain functions.
Ken Taro Wakabayashi, Eugene A Kiyatkin
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia

Scientific Reports
Microglia are the resident immune cells of the central nervous system (CNS) and display diverse functions under both physiological and pathological conditions.
Elliot J. Glotfelty, Lamarque M. Coke, Evan E. Hart, Cole A. Rivell, Amy Phan, Braxton D. Greer, Reinis Svarcbahs, Elizabeth Fielding, Julie Necarsulmer, Lowella V. Fortuno, Francois Vautier, Patricia J. Gearhart, Geoffrey Schoenbaum, Christopher T. Richie, Brandon K. Harvey   +14 more
doaj   +1 more source