Results 11 to 20 of about 315,545 (267)

Arousal and drug abuse [PDF]

Behavioural Brain Research, 2017
The reticular activating system (RAS) is not an amorphous region but distinct nuclei with specific membrane properties that dictate their firing during waking and sleep. The locus coeruleus and raphe nucleus fire during waking and slow wave sleep, with the pedunculopontine nucleus (PPN) firing during both waking and REM sleep, the states manifesting ...
Urbano Suarez, Francisco Jose, Bisagno, Veronica, Garcia Rill, Edgar   +2 more
openaire   +3 more sources

Effects of buprenorphine, methadone, and cariprazine on economic choice between remifentanil and food in squirrel monkeys

Addiction Neuroscience, 2023
We recently reported an economic choice task in which squirrel monkeys chose between differing amounts of remifentanil, a fast-acting opioid, or a food reward to develop a preclinical screen for evaluating potential pharmacotherapies for opioid ...
Alishan S. Amirali, Jacquelin C. Hecker, Hector L. Figueroa-Monsanto, Devin P. Effinger, Rodrigo A. Montoro, Hank P. Jedema, Caleb D. Vogt, Amy Hauck Newman, Charles W. Schindler, Charles W. Bradberry   +9 more
doaj   +1 more source

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor

Nature Communications, 2018
D1-like dopamine receptors are coupled to Golf proteins in the dorsal striatum but Gs in cortical and other areas. Here, the authors demonstrate selective agonism of Gs-coupled versus Golf-coupled D1 receptors.
Hideaki Yano, Ning-Sheng Cai, Min Xu, Ravi Kumar Verma, William Rea, Alexander F. Hoffman, Lei Shi, Jonathan A. Javitch, Antonello Bonci, Sergi Ferré   +9 more
doaj   +1 more source

Phasic excitation of ventral tegmental dopamine neurons potentiates the initiation of conditioned approach behavior: Parametric and reinforcement-schedule analyses

Frontiers in Behavioral Neuroscience, 2014
Midbrain dopamine neurons are implicated in motivation and learning. However, it is unclear how phasic excitation of dopamine neurons, which is implicated in learning, is involved in motivation.
Anton eIlango, Andrew J. Kesner, Carl J. Broker, Dong V. Wang, Satoshi eIkemoto   +4 more
doaj   +1 more source

Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior

Translational Psychiatry, 2021
Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown.
Juan L. Gomez, Jordi Bonaventura, Jacqueline Keighron, Kelsey M. Wright, Dondre L. Marable, Lionel A. Rodriguez, Sherry Lam, Meghan L. Carlton, Randall J. Ellis, Chloe J. Jordan, Guo-hua Bi, Oscar Solis, Marco Pignatelli, Michael J. Bannon, Zheng-Xiong Xi, Gianluigi Tanda, Michael Michaelides   +16 more
doaj   +1 more source

Functional Connectivity Hubs and Networks in the Awake Marmoset Brain

Frontiers in Integrative Neuroscience, 2016
In combination with advances in analytical methods, resting-state fMRI is allowing unprecedented access to achieve a better understanding of the network organization of the brain. Increasing evidence suggests that this architecture may incorporate highly
Annabelle Marie Belcher, Annabelle Marie Belcher, Cecil Chern-Chyi Yen, Lucia eNotardonato, Thomas J. Ross, Nora D. Volkow, Nora D. Volkow, Yihong eYang, Elliot A. Stein, Afonso C Silva, Dardo eTomasi   +10 more
doaj   +1 more source

Robust brain hyperglycemia during general anesthesia: relationships with metabolic brain inhibition and vasodilation

Frontiers in Physiology, 2016
Glucose is the main energetic substrate for the metabolic activity of brain cells and its proper delivery into the extracellular space is essential for maintaining normal neural functions.
R. Aaron eBola, Eugene A Kiyatkin
doaj   +1 more source

Language models in digital psychiatry: challenges with simplification of healthcare materials

NPP-Digital Psychiatry and Neuroscience
Linguistic hurdles in healthcare, such as complex language, significantly affect patient outcomes, including satisfaction with interaction, comprehension of healthcare materials, and engagement with the healthcare system.
Ankit Aich, Tingting Liu, Salvatore Giorgi, Kelsey Isman, Ruhshana Bobojonova, Lyle Ungar, Brenda Curtis   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Behavior-associated and post-consumption glucose entry into the nucleus accumbens extracellular space during glucose free-drinking in trained rats

Frontiers in Behavioral Neuroscience, 2015
Glucose is the primary energetic substrate for the metabolic activity of brain cells and its proper delivery from the arterial blood is essential for neural activity and normal brain functions.
Ken Taro Wakabayashi, Eugene A Kiyatkin
doaj   +1 more source