Results 11 to 20 of about 957,503 (357)
Frontiers in Neuroscience, 2015 Methylenedioxypyrovalerone (MDPV) is generally considered to be a more potent cocaine-like psychostimulant, as it shares a similar pharmacological profile with cocaine and induces similar physiological and locomotor responses.
Ken Taro Wakabayashi +2 more
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Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice
Communications Biology, 2021 Cover et al. develop a method that permits functional MRI of brain dynamics while mice are cued to perform an operant task: licking a spout to receive optogenetic stimulation to the medial prefrontal cortex.
Christopher G. Cover +6 more
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Public spending for illegal drug and alcohol treatment in hospitals: an EU cross-country comparison [PDF]
, 2014 Background: In view of the current economic crisis and the resulting austerity measures being implemented by governments across Europe, public expenditure for substance abuse treatment has increasingly become a subject of discussion.
Christiaens, Johan +2 more
core +3 more sources
Addiction Neuroscience, 2023 We recently reported an economic choice task in which squirrel monkeys chose between differing amounts of remifentanil, a fast-acting opioid, or a food reward to develop a preclinical screen for evaluating potential pharmacotherapies for opioid ...
Alishan S. Amirali +9 more
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Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor
Nature Communications, 2018 D1-like dopamine receptors are coupled to Golf proteins in the dorsal striatum but Gs in cortical and other areas. Here, the authors demonstrate selective agonism of Gs-coupled versus Golf-coupled D1 receptors.
Hideaki Yano +9 more
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Frontiers in Behavioral Neuroscience, 2014 Midbrain dopamine neurons are implicated in motivation and learning. However, it is unclear how phasic excitation of dopamine neurons, which is implicated in learning, is involved in motivation.
Anton eIlango +4 more
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Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior
Translational Psychiatry, 2021 Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown.
Juan L. Gomez +16 more
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Functional Connectivity Hubs and Networks in the Awake Marmoset Brain
Frontiers in Integrative Neuroscience, 2016 In combination with advances in analytical methods, resting-state fMRI is allowing unprecedented access to achieve a better understanding of the network organization of the brain. Increasing evidence suggests that this architecture may incorporate highly
Annabelle Marie Belcher +10 more
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Ecological factors and adolescent marijuana use: results of a prospective study in Santiago, Chile [PDF]
, 2014 PURPOSE: Despite the growing evidence that ecological factors contribute to substance use, the relationship of ecological factors and illicit drugs such as marijuana use is not well understood, particularly among adolescents in Latin America.
Andrade, Fernando H. +6 more
core +2 more sources
Frontiers in Physiology, 2016 Glucose is the main energetic substrate for the metabolic activity of brain cells and its proper delivery into the extracellular space is essential for maintaining normal neural functions.
R. Aaron eBola, Eugene A Kiyatkin
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