Results 31 to 40 of about 2,545,292 (301)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 1993 Newsletter of the Texas Commission on Alcohol and Drug Abuse providing updates the agency and their programs along with news, events, and other information related to addiction prevention and ...
Solis, Olivia Carmichael +1 more
core +8 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Scientific ReportsMicroglia are the resident immune cells of the central nervous system (CNS) and display diverse functions under both physiological and pathological conditions.
Elliot J. Glotfelty +14 more
doaj +1 more source
Machine learning classification of resting state functional connectivity predicts smoking status
Frontiers in Human Neuroscience, 2014 Machine learning-based approaches are now able to examine functional magnetic resonance imaging data in a multivariate manner and extract features predictive of group membership.
Vani ePariyadath +2 more
doaj +1 more source
Nature Communications, 2021 The supramammillary region (SuM) regulates arousal that reinforces and energizes behavioral interaction with the environment. Here the authors investigate how SuM neurons interact with medial septal neurons and ventral tegmental dopamine neurons to ...
Andrew J. Kesner +12 more
doaj +1 more source
Addiction Neuroscience, 2022 Opioid use disorder (OUD) is defined as a compulsion to seek and take opioids, loss of control over intake and the development of a negative emotional state when access to opioids is denied.
Scarlata MJ +8 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Cell Transplantation, 2011 A key limiting factor impacting the success of cell transplantation for Parkinson's disease is the survival of the grafted cells, which are often short lived.
J. Chou +4 more
doaj +1 more source
Behavioural Brain Research, 2017 The reticular activating system (RAS) is not an amorphous region but distinct nuclei with specific membrane properties that dictate their firing during waking and sleep. The locus coeruleus and raphe nucleus fire during waking and slow wave sleep, with the pedunculopontine nucleus (PPN) firing during both waking and REM sleep, the states manifesting ...
Urbano Suarez, Francisco Jose +2 more
openaire +3 more sources