Results 21 to 30 of about 315,545 (267)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia

Scientific Reports
Microglia are the resident immune cells of the central nervous system (CNS) and display diverse functions under both physiological and pathological conditions.
Elliot J. Glotfelty, Lamarque M. Coke, Evan E. Hart, Cole A. Rivell, Amy Phan, Braxton D. Greer, Reinis Svarcbahs, Elizabeth Fielding, Julie Necarsulmer, Lowella V. Fortuno, Francois Vautier, Patricia J. Gearhart, Geoffrey Schoenbaum, Christopher T. Richie, Brandon K. Harvey   +14 more
doaj   +1 more source

Machine learning classification of resting state functional connectivity predicts smoking status

Frontiers in Human Neuroscience, 2014
Machine learning-based approaches are now able to examine functional magnetic resonance imaging data in a multivariate manner and extract features predictive of group membership.
Vani ePariyadath, Elliot A Stein, Thomas J Ross   +2 more
doaj   +1 more source

Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice

Nature Communications, 2021
The supramammillary region (SuM) regulates arousal that reinforces and energizes behavioral interaction with the environment. Here the authors investigate how SuM neurons interact with medial septal neurons and ventral tegmental dopamine neurons to ...
Andrew J. Kesner, Rick Shin, Coleman B. Calva, Reuben F. Don, Sue Junn, Christian T. Potter, Leslie A. Ramsey, Ahmed F. Abou-Elnaga, Christopher G. Cover, Dong V. Wang, Hanbing Lu, Yihong Yang, Satoshi Ikemoto   +12 more
doaj   +1 more source

Cingulate circuits are associated with escalation of heroin use and naloxone-induced increases in heroin self-administration

Addiction Neuroscience, 2022
Opioid use disorder (OUD) is defined as a compulsion to seek and take opioids, loss of control over intake and the development of a negative emotional state when access to opioids is denied.
Scarlata MJ, Keeley RJ, Carmack SA, Tsai P-J, Vendruscolo JCM, Lu H, Koob GF, Vendruscolo LF, Stein EA   +8 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Enhanced Survival of Dopaminergic Neuronal Transplants in Hemiparkinsonian Rats by the p53 Inactivator PFT-α

Cell Transplantation, 2011
A key limiting factor impacting the success of cell transplantation for Parkinson's disease is the survival of the grafted cells, which are often short lived.
J. Chou, N. H. Greig, D. Reiner, B. J. Hoffer, Y. Wang M.D., Ph.D.   +4 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Cortico-amygdala coupling as a marker of early relapse risk in cocaine-addicted individuals

Frontiers in Psychiatry, 2014
Addiction to cocaine is a chronic condition characterized by high rates of early relapse. This study builds on efforts to identify neural markers of relapse risk by studying resting state functional connectivity (rsFC) in neural circuits arising from the
Meredith J Mchugh, Catherine H Demers, Betty Jo eSalmeron, Michael D Devous, Elliot A Stein, Bryon eAdinoff, Bryon eAdinoff   +6 more
doaj   +1 more source