Results 21 to 30 of about 957,503 (357)

National Institute on Drug Abuse Strategic Plan on Reducing Health Disparities [PDF]

, 2002
Unlike other diseases, drug addiction poses many peculiar challenges to health researchers, providers, and public health officials in the search for effective prevention and treatment strategies and policies.
National Institute, on Drug Abuse
core   +2 more sources

The role of setting for ketamine abuse: clinical and preclinical evidence [PDF]

, 2012
Drug abuse is often seen as a unitary phenomenon, partly as a result of the discovery over the past three decades of shared mechanisms of action for addictive substances. Yet the pattern of drug taking is often very different from drug to drug.
Sprenger, Stewart, Tellier, Topp, Triffleman, Vollenweider, Vollenweider, Weir, White   +8 more
core   +1 more source

Detecting a signal in the noise : Monitoring the global spread of novel psychoactive substances using media and other open source information [PDF]

, 2015
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no ...
Canadian Community Epidemiology Network On Drug Use, Center for Substance Abuse Research, European Monitoring Centre For Drugs And Drug Addiction, Sumnall H   +3 more
core   +1 more source

Language models in digital psychiatry: challenges with simplification of healthcare materials

NPP-Digital Psychiatry and Neuroscience
Linguistic hurdles in healthcare, such as complex language, significantly affect patient outcomes, including satisfaction with interaction, comprehension of healthcare materials, and engagement with the healthcare system.
Ankit Aich, Tingting Liu, Salvatore Giorgi, Kelsey Isman, Ruhshana Bobojonova, Lyle Ungar, Brenda Curtis   +6 more
doaj   +1 more source

Behavior-associated and post-consumption glucose entry into the nucleus accumbens extracellular space during glucose free-drinking in trained rats

Frontiers in Behavioral Neuroscience, 2015
Glucose is the primary energetic substrate for the metabolic activity of brain cells and its proper delivery from the arterial blood is essential for neural activity and normal brain functions.
Ken Taro Wakabayashi, Eugene A Kiyatkin
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Cingulate circuits are associated with escalation of heroin use and naloxone-induced increases in heroin self-administration

Addiction Neuroscience, 2022
Opioid use disorder (OUD) is defined as a compulsion to seek and take opioids, loss of control over intake and the development of a negative emotional state when access to opioids is denied.
Scarlata MJ, Keeley RJ, Carmack SA, Tsai P-J, Vendruscolo JCM, Lu H, Koob GF, Vendruscolo LF, Stein EA   +8 more
doaj   +1 more source

Associations of maternal and adolescent religiosity and spirituality with adolescent alcohol use in Chile: implications for social work practice [PDF]

, 2015
To inform social work practice with adolescents who may consume alcohol, we examined if alcohol use among Chilean adolescents varied as a function of their mothers’ and their own religiosity and spirituality.
Andrade, Fernando H., Delva, Jorge, Han, Yoonsun, Sanhueza, Guillermo   +3 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia

Scientific Reports
Microglia are the resident immune cells of the central nervous system (CNS) and display diverse functions under both physiological and pathological conditions.
Elliot J. Glotfelty, Lamarque M. Coke, Evan E. Hart, Cole A. Rivell, Amy Phan, Braxton D. Greer, Reinis Svarcbahs, Elizabeth Fielding, Julie Necarsulmer, Lowella V. Fortuno, Francois Vautier, Patricia J. Gearhart, Geoffrey Schoenbaum, Christopher T. Richie, Brandon K. Harvey   +14 more
doaj   +1 more source