Results 21 to 30 of about 962,829 (360)
Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor
Nature Communications, 2018 D1-like dopamine receptors are coupled to Golf proteins in the dorsal striatum but Gs in cortical and other areas. Here, the authors demonstrate selective agonism of Gs-coupled versus Golf-coupled D1 receptors.
Hideaki Yano +9 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2014 Midbrain dopamine neurons are implicated in motivation and learning. However, it is unclear how phasic excitation of dopamine neurons, which is implicated in learning, is involved in motivation.
Anton eIlango +4 more
doaj +1 more source
Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior
Translational Psychiatry, 2021 Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown.
Juan L. Gomez +16 more
doaj +1 more source
Functional Connectivity Hubs and Networks in the Awake Marmoset Brain
Frontiers in Integrative Neuroscience, 2016 In combination with advances in analytical methods, resting-state fMRI is allowing unprecedented access to achieve a better understanding of the network organization of the brain. Increasing evidence suggests that this architecture may incorporate highly
Annabelle Marie Belcher +10 more
doaj +1 more source
The role of setting for ketamine abuse: clinical and preclinical evidence [PDF]
, 2012 Drug abuse is often seen as a unitary phenomenon, partly as a result of the discovery over the past three decades of shared mechanisms of action for addictive substances. Yet the pattern of drug taking is often very different from drug to drug.
Sprenger +8 more
core +1 more source
Frontiers in Physiology, 2016 Glucose is the main energetic substrate for the metabolic activity of brain cells and its proper delivery into the extracellular space is essential for maintaining normal neural functions.
R. Aaron eBola, Eugene A Kiyatkin
doaj +1 more source
Ecological factors and adolescent marijuana use: results of a prospective study in Santiago, Chile [PDF]
, 2014 PURPOSE: Despite the growing evidence that ecological factors contribute to substance use, the relationship of ecological factors and illicit drugs such as marijuana use is not well understood, particularly among adolescents in Latin America.
Andrade, Fernando H. +6 more
core +2 more sources
Detecting a signal in the noise : Monitoring the global spread of novel psychoactive substances using media and other open source information [PDF]
, 2015 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no ...
Canadian Community Epidemiology Network On Drug Use +3 more
core +1 more source
Language models in digital psychiatry: challenges with simplification of healthcare materials
NPP-Digital Psychiatry and NeuroscienceLinguistic hurdles in healthcare, such as complex language, significantly affect patient outcomes, including satisfaction with interaction, comprehension of healthcare materials, and engagement with the healthcare system.
Ankit Aich +6 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi +6 more
wiley +1 more source