Results 21 to 30 of about 323,640 (268)

Machine learning classification of resting state functional connectivity predicts smoking status

Frontiers in Human Neuroscience, 2014
Machine learning-based approaches are now able to examine functional magnetic resonance imaging data in a multivariate manner and extract features predictive of group membership.
Vani ePariyadath, Elliot A Stein, Thomas J Ross   +2 more
doaj   +1 more source

Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice

Nature Communications, 2021
The supramammillary region (SuM) regulates arousal that reinforces and energizes behavioral interaction with the environment. Here the authors investigate how SuM neurons interact with medial septal neurons and ventral tegmental dopamine neurons to ...
Andrew J. Kesner, Rick Shin, Coleman B. Calva, Reuben F. Don, Sue Junn, Christian T. Potter, Leslie A. Ramsey, Ahmed F. Abou-Elnaga, Christopher G. Cover, Dong V. Wang, Hanbing Lu, Yihong Yang, Satoshi Ikemoto   +12 more
doaj   +1 more source

Cingulate circuits are associated with escalation of heroin use and naloxone-induced increases in heroin self-administration

Addiction Neuroscience, 2022
Opioid use disorder (OUD) is defined as a compulsion to seek and take opioids, loss of control over intake and the development of a negative emotional state when access to opioids is denied.
Scarlata MJ, Keeley RJ, Carmack SA, Tsai P-J, Vendruscolo JCM, Lu H, Koob GF, Vendruscolo LF, Stein EA   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Enhanced Survival of Dopaminergic Neuronal Transplants in Hemiparkinsonian Rats by the p53 Inactivator PFT-α

Cell Transplantation, 2011
A key limiting factor impacting the success of cell transplantation for Parkinson's disease is the survival of the grafted cells, which are often short lived.
J. Chou, N. H. Greig, D. Reiner, B. J. Hoffer, Y. Wang M.D., Ph.D.   +4 more
doaj   +1 more source

Arousal and drug abuse [PDF]

Behavioural Brain Research, 2017
The reticular activating system (RAS) is not an amorphous region but distinct nuclei with specific membrane properties that dictate their firing during waking and sleep. The locus coeruleus and raphe nucleus fire during waking and slow wave sleep, with the pedunculopontine nucleus (PPN) firing during both waking and REM sleep, the states manifesting ...
Urbano Suarez, Francisco Jose, Bisagno, Veronica, Garcia Rill, Edgar   +2 more
openaire   +3 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Cortico-amygdala coupling as a marker of early relapse risk in cocaine-addicted individuals

Frontiers in Psychiatry, 2014
Addiction to cocaine is a chronic condition characterized by high rates of early relapse. This study builds on efforts to identify neural markers of relapse risk by studying resting state functional connectivity (rsFC) in neural circuits arising from the
Meredith J Mchugh, Catherine H Demers, Betty Jo eSalmeron, Michael D Devous, Elliot A Stein, Bryon eAdinoff, Bryon eAdinoff   +6 more
doaj   +1 more source