Results 131 to 140 of about 4,201,815 (397)

Economic Benefits of Treating Substance Abuse Outweigh Costs [PDF]

, 2006
Summarizes findings from an analysis of the effects of drug addiction treatment on medical care, mental health services, criminal activity, employment earnings and government transfer payments.
Lauren Necochea
core  

Drugs, Crime, and the Epigenetics of Hedonic Allostasis [PDF]

, 2012
Researchers have found staggering numbers of drug addicts among incarcerated populations and have conceded that drug abuse is an important correlate of deviant behavior, but few included an understanding of the biological process leading to drug ...
Bolen, Jonathan D., Johnson, Hailey, Walsh, Anthony   +2 more
core   +2 more sources

THE INTERNATIONAL CONTROL OF DRUGS OF ADDICTION: The Present Position of the International Opium Convention, 1912 [PDF]

, 1919
William Collins
openalex   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)—From trajectories to mechanisms and interventions

Addiction Biology, 2019
One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs ...
A. Heinz, F. Kiefer, M. Smolka, T. Endrass, C. Beste, A. Beck, Shuyan Liu, Alexander Genauck, L. Romund, T. Banaschewski, F. Bermpohl, L. Deserno, R. Dolan, D. Durstewitz, U. Ebner-Priemer, H. Flor, A. Hansson, Christine Marcelle Heim, D. Hermann, S. Kiebel, P. Kirsch, C. Kirschbaum, G. Koppe, M. Marxen, A. Meyer-Lindenberg, Wolfgang E Nagel, H. R. Noori, M. Pilhatsch, Josef Priller, M. Rietschel, N. Romanczuk-Seiferth, F. Schlagenhauf, W. Sommer, Jan Stallkamp, A. Ströhle, A. Stock, G. Winterer, C. Winter, H. Walter, S. Witt, S. Vollstädt-Klein, M. Rapp, H. Tost, R. Spanagel   +43 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Healing a Broken System: Veterans and the War on Drugs [PDF]

, 2012
This report examines the plight of returning veterans who struggle with incarceration and psychological wounds of war such as addiction and post-traumatic stress disorder -- and suggests reforms that could improve the health and preserve the freedom of ...

core  

Issues and challenges of drug addiction among students in Malaysia [PDF]

, 2016
The drug addiction problem is a global problem faced by all nations, and Malaysia was not exempted from this phenomenon. According to the United Nations Drug Control Programme (UNDCP), Malaysia, among Southeast Asian nations, ranks fifth in the number of
Madon, Zainal, Razali, Asbah
core   +1 more source

Drug Addiction [PDF]

, 1940

openalex   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source