Results 131 to 140 of about 435,266 (312)

RECOVEU Policy and Practice Review: Work Package 3 - Establishing context. Grundtvig Multilateral - EU Lifelong Learning Programme. Project Number: 538955-LLP-1-2013-1-UK-GRUNDTVIG-GMP [PDF]

, 2014
A review of the policy relating to drug addiction and treatment in the UK, Ireland, Cyprus, Romania and Italy. This document provides the contextual background for the RECOVEU project : A participative approach to curriculum development for adults in ...
Amariei, Nicoleta, Catalfio, Federica, Copoeru, Ion, Dillon, Sonya, Fabrizi, Gabriella, Hughes, Amanda, McAlleenan, Gerry, Nocente, Marilena, Patouris, Eliza, Rowley, Jane, SLACK, Kim, Solomou, Maria, Stanceanu, Mihaela, Themistokleous, Sotiris, Varga, Claudia   +14 more
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A maternal high-fat diet during pregnancy and lactation induced depression-like behavior in offspring and myelin-related changes in the rat prefrontal cortex

Frontiers in Molecular Neuroscience
In accordance with the developmental origins of health and disease, early-life environmental exposures, such as maternal diet, can enhance the probability and gravity of health concerns in their offspring in the future.
Małgorzata Frankowska, Paulina Surówka, Kinga Gawlińska, Małgorzata Borczyk, Michał Korostyński, Małgorzata Filip, Irena Smaga   +6 more
doaj   +1 more source

Addiction Enabling Doctors-- So You Want To Stop The Heroin And Drug Abuse Epidemic? [PDF]

, 2015
Samuel A Nigro
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Integrating an exercise program into opioid agonist therapy: a pilot study on feasibility, fitness improvements, and participation challenges

Addiction Science & Clinical Practice
Background People receiving opioid agonist therapy (OAT) face high risk of comorbidities, including cardiovascular and mental health disorders. Integrating exercise programs with OAT may reduce health disparities and improve well-being.
Einar Furulund, Siv-Elin Leirvåg Carlsen, Silvia Eiken Alpers, Jørn Henrik Vold, Karl Trygve Druckrey-Fiskaaen, Tesfaye Madebo, Sindre M. Dyrstad, Torgeir Gilje Lid, Lars Thore Fadnes   +8 more
doaj   +1 more source

Addressing the Opioid Crisis in Vermont: Lessons Learned from Primary Care Physicians [PDF]

, 2016
Background: Opioid Misuse in Vermont: The number of Vermonters seeking treatment for opioid abuse is increasing, particularly in Chittenden County. Emergency department visits and deaths related to opioid misuse continue to increase, both locally and ...
Carney, Jan, Cote, Elizabeth, Henderson, Tim, MacLean, Charles, Markowitz, Molly, Petchers, Adam, Rocque, Brittany, Sheridan, Andrew, Sugiyama, Nathanial, Wyatt, Lyndsey   +9 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Factors associated with gaps in naloxone knowledge: evidence from a 2022 great plains survey

Harm Reduction Journal
Background The rising prevalence of fast-acting opioids in the USA suggests the increased need for non-professional first responder administration of naloxone.
Spencer Cooper-Ohm, Patrick Habecker, Ryan Humeniuk, Rick A. Bevins   +3 more
doaj   +1 more source

The Habenular Receptor GPR151 Regulates Addiction Vulnerability Across Drug Classes [PDF]

, 2019
Beatriz Antolin‐Fontes, Kun Li, Jessica L. Ables, Michael H. Riad, Andreas Görlich, Maya Williams, Cuidong Wang, Sylvia M. Lipford, Maria Dao, Henrik Molina, Jianxi Liu, Paul J. Kenny, Inés Ibáñez-Tallon   +12 more
openalex   +1 more source