Results 31 to 40 of about 435,266 (312)

Oral Administration of Levo-Tetrahydropalmatine Attenuates Reinstatement of Extinguished Cocaine Seeking by Cocaine, Stress or Drug-Associated Cues in Rats [PDF]

, 2011
Cocaine addiction is characterized by a persistently heightened susceptibility to drug relapse. For this reason, the identification of medications that prevent drug relapse is a critical goal of drug abuse research.
Baker, David A., Bohr, Colin, Figueroa-Guzman, Yazmin, Graf, Evan N., Li, Shi-Jiang, Mantsch, John R., Mueller, Christopher R, Vranjkovic, Oliver, Wisniewski, Samantha, Yang, Zheng   +9 more
core   +2 more sources

Therapeutic potential of PIMSR, a novel CB1 receptor neutral antagonist, for cocaine use disorder: evidence from preclinical research

Translational Psychiatry, 2022
Cannabinoid CB1 receptors (CB1Rs) have been major targets in medication development for the treatment of substance use disorders. However, clinical trials with rimonabant, a CB1R antagonist/inverse agonist, failed due to severe side effects.
Ewa Galaj, Briana Hempel, Allamar Moore, Benjamin Klein, Guo-Hua Bi, Eliot L. Gardner, Herbert H. Seltzman, Zheng-Xiong Xi   +7 more
doaj   +1 more source

Spirituality, Religiosity, Depression, Anxiety, and Drug-Use Consequences During Methadone Maintenance Therapy [PDF]

, 2013
Substance addiction is damaging to the health of persons, families, and society. Often the person with addiction has decreased spirituality and religiosity and suffers from anxiety, depression, or both, increasing the risk for continued substance use and
Piacentine, Linda B.
core   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Prevalence and determinants of nicotine dependence among rural elderly of four ethnic groups in Yunnan province: a cross-sectional study with structural equation modeling analysis

Zhongguo gonggong weisheng
ObjectiveTo understand the prevalence and influencing factors of nicotine dependence among rural elderly of Han, Dai, Hani, and Bai ethnicity in Yunnan province, to provide a reference for developing strategies to alleviate nicotine dependence symptoms ...
Guohui LI, Lan LIU, Duli LIU, Zizi YU, Mei ZUO, You HUANG, Qin LI, Le CAI   +7 more
doaj   +1 more source

Novel psychoactive substance use by mental health service consumers: an online survey of inpatient health professionals’ views and experiences [PDF]

, 2017
Purpose: There is evidence that novel psychoactive substances (NPS) are commonly used by people with severe mental illness. The aim of the study was to undertake a scoping survey to explore inpatient mental health workers' perceptions of NPS use by ...
Clinical Guidelines on Drug Misuse and Dependence Update 2017 Independent Expert Working Group, Department of Health, European Monitoring Centre for Drugs and Drug Addiction, European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), IBM   +4 more
core   +1 more source

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Ethnic differences in prevalence and behaviors of smoking and their association with chronic obstructive pulmonary disease among the elderly in rural southwest China: A cross-sectional study

Tobacco Induced Diseases
Introduction This study examines how prevalence and behaviors of smoking differ by ethnicity and their associations with chronic obstructive pulmonary disease (COPD) among elderly people of four ethnicities in rural southwest China.
Guo-hui Li, Gui-yi Wang, Lan Liu, Yi Zhao, Xia Wu, Allison R. Golden, Le Cai   +6 more
doaj   +1 more source

Adenosine A_2AReceptors in Substance Use Disorders: A Focus on Cocaine

Cells, 2020
Several psychoactive drugs can evoke substance use disorders (SUD) in humans and animals, and these include psychostimulants, opioids, cannabinoids (CB), nicotine, and alcohol. The etiology, mechanistic processes, and the therapeutic options to deal with
Karolina Wydra, Dawid Gawliński, Kinga Gawlińska, Małgorzata Frankowska, Dasiel O. Borroto-Escuela, Kjell Fuxe, Małgorzata Filip   +6 more
doaj   +1 more source

How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction. [PDF]

, 2015
Drug addiction is a complex neuropsychiatric disorder that affects a subset of the individuals who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained despite adverse consequences and intense drug craving.
Belin, David, Belin-Rauscent, Aude, Bonci, Antonello, Fouyssac, Maxime   +3 more
core   +2 more sources