Results 31 to 40 of about 4,201,815 (397)

Detecting a signal in the noise : Monitoring the global spread of novel psychoactive substances using media and other open source information [PDF]

open access: yes, 2015
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no ...
Canadian Community Epidemiology Network On Drug Use   +3 more
core   +1 more source

Sleep-Disturbance-Induced Microglial Activation Involves CRH-Mediated Galectin 3 and Autophagy Dysregulation

open access: yesCells, 2022
Chronic sleep disturbances (CSDs) including insomnia, insufficient sleep time, and poor sleep quality are major public health concerns around the world, especially in developed countries.
Liyang Guo   +8 more
doaj   +1 more source

Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory

open access: yesNeuropsychopharmacology, 2020
Drug addiction may be a goal-directed choice driven by excessive drug value in negative affective states, a habit driven by strong stimulus−response associations, or a compulsion driven by insensitivity to costs imposed on drug seeking. Laboratory animal
L. Hogarth
semanticscholar   +1 more source

Varenicline Targets the Reinforcing-Enhancing Effect of Nicotine on Its Associated Salient Cue During Nicotine Self-administration in the Rat

open access: yesFrontiers in Behavioral Neuroscience, 2019
Nicotine is acknowledged as the key addictive compound of tobacco. Varenicline (Champix® or Chantix®), mainly acting as a partial agonist at the α4β2 nicotinic receptor, is an approved smoking cessation pharmacotherapy, although with efficacy limited to ...
Vernon Garcia-Rivas   +13 more
doaj   +1 more source

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On.

open access: yesAnnual Review of Psychology, 2016
A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by a transition from prefrontal cortical to striatal control over drug seeking ...
B. Everitt, T. Robbins
semanticscholar   +1 more source

Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons [PDF]

open access: yes, 2010
Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental stimuli previously associated with drug taking.
Bilbao, Ainhoa   +11 more
core   +2 more sources

Neuroanatomic differences of the brain in males and females

open access: yesАнналы клинической и экспериментальной неврологии, 2017
Gender distribution is an important factor in patient cohorts which may influence the results acquired in studies on pathogenesis and treatment of neuropsychiatric disorders.
Anna G. Polunina, Evgeniy A. Bryun
doaj   +1 more source

Drug Addictions [PDF]

open access: yesThe Journal of Nervous and Mental Disease, 1907
n ...
openaire   +1 more source

Modafinil dependence: A case with attention-deficit/hyperactivity disorder [PDF]

open access: yes, 2018
Modafinil is generally known as a drug with low addiction potential. There are few case reports in the literature demonstrating that Modafinil, stated being capable of diminishing symptoms of attention deficit/hyperactivity disorder (ADHD), causes ...
Alaçam, Hüseyin   +4 more
core   +1 more source

A Fifty-year challenge in managing drug addiction in Malaysia [PDF]

open access: yes, 2008
The history of substance abuse in Malaysia can be divided into pre- and post-independent era. In pre-independence, the main drug of abuse was opium which was initially consumed by immigrants from China who were introduced by the British ...
Habil, Mohamad Hussain   +3 more
core   +1 more source

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