Results 41 to 50 of about 4,201,815 (397)

How fast and how often: the pharmacokinetics of drug use are decisive in addiction [PDF]

, 2015
How much, how often and how fast a drug reaches the brain determine the behavioural and neuroplastic changes associated with the addiction process. Despite the critical nature of these variables, the drug addiction field often ignores pharmacokinetic ...
Allain, Florence, Minogianis, Ellie-Anna, Roberts, David C.S., Samaha, Anne-Noël   +3 more
core   +2 more sources

Harm reduction in the Heartland: public knowledge and beliefs about naloxone in Nebraska, USA

Harm Reduction Journal, 2022
Background Opioid-related overdose deaths have been increasing in the United States (U.S.) in the last twenty years, creating a public health challenge.
Allison Schlosser, Patrick Habecker, Rick Bevins   +2 more
doaj   +1 more source

Collecting behavioural addiction treatment data using Freedom of Information requests [PDF]

, 2014
There is now a growing movement that views a number of behaviours as potentially addictive including many that do not involve the ingestion of a drug (i.e., behavioural addictions such as gambling addiction and sex addiction).
Dhuffar, M, Griffiths, M
core   +1 more source

Quercetin Mitigates Methamphetamine-Induced Anxiety-Like Behavior Through Ameliorating Mitochondrial Dysfunction and Neuroinflammation

Frontiers in Molecular Neuroscience, 2022
Methamphetamine (MA) abuse results in neurotoxic outcomes, including increased anxiety and depression. Studies have reported an association between MA exposure and anxiety, nonetheless, the underlying mechanism remains elusive.
Fengrong Chen, Fengrong Chen, Jiaxue Sun, Jiaxue Sun, Cheng Chen, Cheng Chen, Yongjin Zhang, Yongjin Zhang, Lei Zou, Lei Zou, Zunyue Zhang, Zunyue Zhang, Minghui Chen, Minghui Chen, Hongjin Wu, Weiwei Tian, Yu Liu, Yu Xu, Yu Xu, Huayou Luo, Huayou Luo, Mei Zhu, Juehua Yu, Juehua Yu, Qian Wang, Kunhua Wang, Kunhua Wang   +26 more
doaj   +1 more source

Drug Addiction [PDF]

, 2009
Many drugs of abuse, including cannabinoids, opioids, alcohol and nicotine, can alter the levels of endocannabinoids in the brain. Recent studies show that release of endocannabinoids in the ventral tegmental area can modulate the reward-related effects of dopamine and might therefore be an important neurobiological mechanism underlying drug addiction.
Zuzana, Justinova, Leigh V, Panlilio, Steven R, Goldberg   +2 more
openaire   +2 more sources

Current Concepts on Drug Abuse and Dependence [PDF]

, 2015
Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about ...
Baconi, Daniela Luiza, Bălălău, Cristian, Ciobanu, Anne-Marie, Cobani, Oana Denisa, Negrei, Carolina, Vlăsceanu, Ana Maria   +5 more
core   +5 more sources

Therapeutic potential of PIMSR, a novel CB1 receptor neutral antagonist, for cocaine use disorder: evidence from preclinical research

Translational Psychiatry, 2022
Cannabinoid CB1 receptors (CB1Rs) have been major targets in medication development for the treatment of substance use disorders. However, clinical trials with rimonabant, a CB1R antagonist/inverse agonist, failed due to severe side effects.
Ewa Galaj, Briana Hempel, Allamar Moore, Benjamin Klein, Guo-Hua Bi, Eliot L. Gardner, Herbert H. Seltzman, Zheng-Xiong Xi   +7 more
doaj   +1 more source

Recent updates on incubation of drug craving: a mini-review [PDF]

, 2015
Cue-induced drug craving progressively increases after prolonged withdrawal from drug self-administration in laboratory animals, a behavioral phenomenon termed 'incubation of drug craving.' Studies over the years have revealed several important neural ...
Abdolahi, Bedi, Bienkowski, Chauvet, Chauvet, Conrad, Counotte, Fanous, Gawin, Grimm, Grimm, Guillem, Halbout, Hollander, Koya, Krasnova, Lee, Li, Li, Li, Loweth, Lu, Lu, Lu, Ma, Marchant, Neisewander, Pickens, Purgianto, Shalev, Shepard, Solinas, Sorge, Theberge, Thiel, Thiel, Tran-Nguyen, Uejima, Wang, Xi   +39 more
core   +1 more source

Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.

American Journal of Psychiatry, 2002
OBJECTIVE Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction.
Rita Z. Goldstein, N. Volkow
semanticscholar   +1 more source

Neurobiological Mechanisms That Contribute to Stress-related Cocaine Use [PDF]

, 2014
The ability of stressful life events to trigger drug use is particularly problematic for the management of cocaine addiction due to the unpredictable and often uncontrollable nature of stress.
Ahmed, Ahmed, Ambroggi, Amphoux, Asanuma, Back, Badrinarayan, Barik, Beckerman, Beckstead, Behan, Berridge, Blacktop, Brady, Briand, Brischoux, Broadbear, Brown, Brown, Bruijnzeel, Buffalari, Butts, Campioni, Capriles, Chen, Cintra, Coffey, Conrad, Cottler, Day, de Jong, de Kloet, De La Garza, De Vries, Deroche-Gamonet, Dobi, Dong, Duan, Dumont, Duncan, Egli, Engel, Erb, Erb, Erb, Erb, Erb, Erb, Feltenstein, Forray, Fox, Fox, Galici, Gasser, Gasser, Geisler, Georges, Ghitza, Goeders, Gonzalez-Islas, Gorboulev, Graf, Graf, Gründemann, Hahn, Harfstrand, Iversen, Jayme R. McReynolds, Jennings, Jobes, John R. Mantsch, Jordan M. Blacktop, Kalivas, Kash, Kippin, Koob, Koob, Korotkova, Kreibich, Kudo, Lee, Leri, Lewis, Lodge, Lê, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, McEwen, McFarland, Nobis, Oleson, Oliver Vranjkovic, Orio, Ostrander, Paul J. Gasser, Preston, Rainbow, Redila, Refojo, Ribeiro Do Couto, Riegel, Robert C. Twining, Rodaros, Roitman, Rounsaville, Saal, Sanchez, Sartor, Schulkin, Seamans, Shaham, Shaham, Shaham, Shalev, Shelton, Shields, Shin, Silberman, Sinha, Sinha, Sinha, Smith, Specio, Steffensen, Tagliaferro, Tasker, Ungless, Ungless, Ungless, Van Pett, Vialou, Vranjkovic, Wanat, Wang, Wang, Wang, Wang, Ward, Wee, Wee, Wei, Wellman, Wise, Yamaguchi, Zahm, Zoli   +149 more
core   +2 more sources