Results 11 to 20 of about 7,897,516 (385)

US Food and Drug Administration Accelerated Approval Program for Nononcology Drug Indications Between 1992 and 2018

JAMA Network Open, 2022
This cohort study evaluates how the US Food and Drug Administration (FDA) accelerated approval program has been used for nononcology drugs over a period of 26 years.
Kenji Omae, Akira Onishi, E. Sahker, T. Furukawa   +3 more
semanticscholar   +1 more source

Adverse Drug Reactions and Toxicity of the Food and Drug Administration–Approved Antisense Oligonucleotide Drugs

Drug Metabolism And Disposition, 2022
The market for large molecule biologic drugs has grown rapidly, including antisense oligonucleotide (ASO) drugs. ASO drugs work as single-stranded synthetic oligonucleotides that reduce production or alter functions of disease-causing proteins through ...
Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P Rasmussen, R. Bahal, Xiao-bo Zhong, J. Manautou   +7 more
semanticscholar   +1 more source

Comparison of Amitriptyline and US Food and Drug Administration–Approved Treatments for Fibromyalgia

JAMA Network Open, 2022
This systematic review and network meta-analysis compares amitriptyline with Food and Drug Administration–approved treatments for fibromyalgia related to sleep, fatigue, and health-related quality of life outcomes.
Hussein M Farag, Ismaeel Yunusa, H. Goswami, I. Sultan, J. Doucette, T. Eguale   +5 more
semanticscholar   +1 more source

The contribution of smoking-attributable mortality to differences in mortality and life expectancy among US African-American and white adults, 2000-2019

Demographic Research, 2022
Background: The role of smoking in racial disparities in mortality and life expectancy in the United States has been examined previously, but up-to-date estimates are generally unavailable, even though smoking prevalence has declined in recent decades.
Brian L. Rostron, Cindy M. Chang, Brittny C. Davis Lynn, Chunfeng Ren, Esther Salazar, Bridget K. Ambrose   +5 more
doaj   +1 more source

The Options for Neuraxial Drug Administration

CNS Drugs, 2022
Neuraxial drug administration, i.e., the injection of drugs into the epidural or intrathecal space to produce anesthesia or analgesia, is a technique developed more than 120 years ago.
H. Hermanns, Elke M E Bos, M. L. van Zuylen, M. Hollmann, M. Stevens   +4 more
semanticscholar   +1 more source

Food and Drug Administration

Definitions, 2020
The Food and Drug Administration is responsible for maintaining a national program to protect the public health from unnecessary and harmful radiation emitted by radiation products.
Arif Subhan
semanticscholar   +1 more source

Anticancer Drugs Approved by the US Food and Drug Administration From 2009 to 2020 According to Their Mechanism of Action

JAMA Network Open, 2021
Key Points Question How often are anticancer drugs approved based on a new mechanism of action? Findings In this cross-sectional study of 332 US Food and Drug Administration–approved anticancer drugs from 2009 to 2020, 16% of approvals were based on a ...
T. Olivier, A. Haslam, V. Prasad
semanticscholar   +1 more source

Dimensional variability characterization of additively manufactured lattice coupons

3D Printing in Medicine, 2022
Background Additive manufacturing (AM), commonly called 3D Printing (3DP), for medical devices is growing in popularity due to the technology’s ability to create complex geometries and patient-matched products.
Kirstie Lane Snodderly, Magdalene Fogarasi, Yutika Badhe, Ankit Parikh, Daniel Porter, Albert Burchi, Laura Gilmour, Matthew Di Prima   +7 more
doaj   +1 more source

Patterns of Routes of Administration and Drug Tampering for Nonmedical Opioid Consumption: Data Mining and Content Analysis of Reddit Discussions [PDF]

J Med Internet Res 2021;23(1):e21212, 2021
The complex unfolding of the US opioid epidemic in the last 20 years has been the subject of a large body of medical and pharmacological research, and it has sparked a multidisciplinary discussion on how to implement interventions and policies to effectively control its impact on public health.
arxiv   +1 more source

A mathematical model of reward-mediated learning in drug addiction [PDF]

Chaos 32, 021102 (2022), 2022
Substances of abuse are known to activate and disrupt neuronal circuits in the brain reward system. We propose a simple and easily interpretable dynamical systems model to describe the neurobiology of drug addiction that incorporates the psychiatric concepts of reward prediction error (RPE), drug-induced incentive salience (IST), and opponent process ...
arxiv   +1 more source