Results 11 to 20 of about 2,691,356 (356)

Intranasal Administration of Drugs [PDF]

open access: yesArchives of Otolaryngology–Head & Neck Surgery, 2008
To investigate how nasally applied substances distribute in the nose depending on the form of application.Observer-blinded study.University hospital research unit.Fifteen healthy volunteers aged 22 to 32 years.Forms of application included (1) nasal drops applied with a pipette, (2) nasal spray, and (3) a system producing squirts.
Mandy Scheibe   +3 more
openaire   +2 more sources

A drug administration problem

open access: yesMathematical and Computer Modelling, 1991
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
George Leitmann, C. S. Lee
openaire   +3 more sources

The continued value of disk diffusion for assessing antimicrobial susceptibility in clinical laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group [PDF]

open access: yes, 2018
Expedited pathways to antimicrobial agent approval by the U.S. Food and Drug Administration (FDA) have led to increased delays between drug approval and the availability of FDA-cleared antimicrobial susceptibility testing (AST) devices.
Burnham, Carey-Ann D   +6 more
core   +2 more sources

Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

open access: yesParticle and Fibre Toxicology, 2017
Background As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate whether gold (
James L. Weaver   +19 more
doaj   +1 more source

Cocaine self-administration in the mouse: A low-cost, chronic catheter preparation [PDF]

open access: yes, 2012
Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the ...
Brian Cadle   +4 more
core   +3 more sources

Decoding kinase-adverse event associations for small molecule kinase inhibitors

open access: yesNature Communications, 2022
Small molecule kinase inhibitors (SMKIs) are being approved at a fast pace under expedited programs for anticancer treatment. Here, the authors employ a machine-learning model to examine the relationships between kinase targets and adverse events in the ...
Xiajing Gong   +8 more
doaj   +1 more source

Nasal Drug Delivery Systems: An Overview [PDF]

open access: yes, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R.   +3 more
core   +1 more source

Atezolizumab potentiates Tcell-mediated cytotoxicity and coordinates with FAK to suppress cell invasion and motility in PD-L1+ triple negative breast cancer cells

open access: yesOncoImmunology, 2019
Immune check point inhibitors targeting programmed cell death protein-1 (PD-1) and its ligand (PD-L1) have shown clinical success in treatment of human malignancies.
Nishant Mohan   +7 more
doaj   +1 more source

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