Results 61 to 70 of about 2,691,356 (356)

Valuation implications of pharmaceutical companies' R&D regulatory approval notifications [PDF]

, 2013
This paper examines shareholder wealth effects surrounding applications to, and approvals by, the United States Food and Drug Administration (FDA) for firms listed on the New York (NYSE) and London (LSE) stock exchanges.
Hamill, P.A., McIlkenny, P., Opong, K.K.
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children [PDF]

, 2018
Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs).
Arasi, Stefania, Barni, Simona, Bottau, Paolo, Caffarelli, Carlo, Caimmi, Davide, Caimmi, Silvia, Cardinale, Fabio, Comberiati, Pasquale, Crisafulli, SEBASTIANO GIUSEPPE, Di Mauro, Dora, Diaferio, Lucia, Duse, Marzia, Franceschini, Fabrizio, Liotti, Lucia, Marseglia, Gianluigi, Mastrorilli, Carla, Mori, Francesca, Paravati, Francesco, Pelosi, Umberto, Saretta, Francesca   +19 more
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Enhancing the incorporation of the patient’s voice in drug development and evaluation

Research Involvement and Engagement, 2018
Plain English summary People living with a condition are uniquely positioned to inform the understanding of the therapeutic context for drug development and evaluation. In 2012, the U.S.
Meghana Chalasani, Pujita Vaidya, Theresa Mullin   +2 more
doaj   +1 more source

Evaluation of Medication Error Reports Sent to Food and Drug Deputy From Hospitals Affiliated to Mazandaran University of Medical Sciences, Mazandaran Province, Iran, 2015-2018

Pharmaceutical and Biomedical Research, 2020
Background: Medical errors are one of the most common threats to patient safety. Medication errors have several consequences, including the increase in patients’ mortality, length of stay, and healthcare costs.
Mohammad Eslami Jouybari, Fatemeh Izadpanah, Mina Amini   +2 more
doaj   +1 more source

Lociq provides a loci-seeking approach for enhanced plasmid subtyping and structural characterization

Communications Biology, 2023
Antimicrobial resistance (AMR) monitoring for public health is relying more on whole genome sequencing to characterize and compare resistant strains. This requires new approaches to describe and track AMR that take full advantage of the detailed data ...
Lucas Harrison, Shaohua Zhao, Cong Li, Patrick F. McDermott, Gregory H. Tyson, Errol Strain   +5 more
doaj   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA

BMC Bioinformatics, 2019
Background Adverse Drug Reactions (ADRs) are of great public health concern. FDA-approved drug labeling summarizes ADRs of a drug product mainly in three sections, i.e., Boxed Warning (BW), Warnings and Precautions (WP), and Adverse Reactions (AR), where
Leihong Wu, Taylor Ingle, Zhichao Liu, Anna Zhao-Wong, Stephen Harris, Shraddha Thakkar, Guangxu Zhou, Junshuang Yang, Joshua Xu, Darshan Mehta, Weigong Ge, Weida Tong, Hong Fang   +12 more
doaj   +1 more source