Results 1 to 10 of about 1,034,777 (227)

Random-ratio schedules produce greater demand for i.v. drug administration than fixed-ratio schedules in rhesus monkeys [PDF]

Psychopharmacology, 2014
Organisms emit more responses when food is provided according to random as compared with fixed schedules of reinforcement. Similarly, many human behaviors deemed compulsive are maintained on variable schedules (e.g., gambling). If greater amounts of behavior are maintained by drugs of abuse when earned according to variably reinforced schedules, this ...
Carla H, Lagorio, Gail, Winger
openaire   +3 more sources

Intranasal cocaine self-administration in male mice [PDF]

Nature Communications
Intravenous drug self-administration has been widely used in behavioral neuroscience to model addiction and heightened motivational states; however, the technique is notoriously difficult and its utility has been in steady decline.
Kirsty R. Erickson, Yizhen Quan, Zahra Z. Farahbakhsh, Hannah E. Branthwaite, Keaton Song, Justin D. Kim, Janice J. Lee, Katherine N. Gibson-Corley, Eyal Y. Kimchi, Cody A. Siciliano   +9 more
doaj   +2 more sources

Nicotine and cocaine self-administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats [PDF]

Behavioural Pharmacology, 2010
There appears to be a relatively narrow range of contingencies in which intravenous (i.v) infusions of nicotine will maintain responding in rats. The schedule of reinforcement typically used when investigating i.v. nicotine self-administration is a simple fixed-ratio (FR) schedule.
Dustin J, Stairs, Nichole M, Neugebauer, Michael T, Bardo   +2 more
openaire   +3 more sources

Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms [PDF]

Frontiers in Pharmacology, 2014
Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy model of depression with ...
Petra eAmchova, Petra eAmchova, Jana eKucerova, Jana eKucerova, Valentina eGiugliano, Zuzana eBabinska, Zuzana eBabinska, Mary Tresa Zanda, Maria eScherma, Ladislav eDusek, Paola eFadda, Paola eFadda, Paola eFadda, Vincenzo eMicale, Alexandra eSulcova, Walter eFratta, Walter eFratta, Walter eFratta, Liana eFattore, Liana eFattore   +19 more
doaj   +3 more sources

Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy

Journal of Neuroscience Methods, 1996
Drug self-administration studies have recently employed progressive ratio (PR) schedules to examine psychostimulant and opiate reinforcement. This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats.
N R, Richardson, D C, Roberts
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Low-dose (5 mg/kg) desferrioxamine treatment in acutely aluminium-intoxicated haemodialysis patients using two drug administration schedules

Nephrology Dialysis Transplantation, 1996
According to the recommendations proposed at The Consensus Conference on Diagnosis and Treatment of Aluminium Overload in End-Stage Renal Failure Patients, Paris, 1992 low-dose desferrioxamine (DFO) treatment was applied for the first time in 41 acutely aluminium-intoxicated patients.DFO-related neurological/ophthalmological side-effects were observed ...
Barata, J.D., d' Haese, Patrick C., Pires, C., Lamberts, L.V., Simoes, J., de Broe, Marc E.   +5 more
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Model‐Informed Therapeutic Dose Optimization Strategies for Antibody–Drug Conjugates in Oncology: What Can We Learn From US Food and Drug Administration–Approved Antibody–Drug Conjugates?

Clinical pharmacology and therapy, 2021
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the cytotoxicity of a chemical agent. They represent a rapidly evolving area of oncology drug development and hold significant promise.
Michael Z. Liao, D. Lu, M. Kågedal, D. Miles, D. Samineni, Stephanie N. Liu, Chunze Li   +6 more
semanticscholar   +1 more source

Preclinical Determinants of Drug Choice under Concurrent Schedules of Drug Self-Administration [PDF]

Advances in Pharmacological Sciences, 2012
Drug self-administration procedures have played a critical role in the experimental analysis of psychoactive compounds, such as cocaine, for over 50 years. While there are numerous permutations of this procedure, this paper will specifically focus on choice procedures using concurrent schedules of intravenous drug self-administration.
Banks, Matthew L., Negus, S. Stevens
openaire   +5 more sources

The progressive ratio and fixed ratio 1 schedules of cocaine self-administration in rats convey the same information

Scientific Reports, 2022
Progressive ratio (PR) schedules of drug delivery are used to determine the ‘motivational’ state of an animal and drug ‘reinforcing efficacy’. This widely held interpretation is supported mainly by the observation that the PR breakpoint (BP) is ...
Vladimir L. Tsibulsky, Andrew B. Norman
doaj   +1 more source

Administration of four different doses of gabapentin reduces awakening from breakthrough pain and adverse effects in outpatients with neuropathic pain during the initial titration [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundGabapentin is a safe and well-tolerated anticonvulsant with a wide therapeutic index, and it is used for neuropathic pain. The aim of this study was to compare previous dosing methods with the administration of four different doses of ...
Jong-Yeun Yang, Won Il Lee, Woo-Kyung Shin, Cheul Hong Kim, Seong-Wan Baik, Kyung-Hoon Kim   +5 more
doaj   +1 more source