Results 11 to 20 of about 1,034,896 (346)

The development of a preference for cocaine over food identifies individual rats with addiction-like behaviors. [PDF]

PLoS ONE, 2013
Cocaine dependence is characterized by compulsive drug taking that supercedes other recreational, occupational or social pursuits. We hypothesized that rats vulnerable to addiction could be identified within the larger population based on their ...
Adam N Perry, Christel Westenbroek, Jill B Becker   +2 more
doaj   +1 more source

A dog model for acetaminophen-induced fulminant hepatic failure. [PDF]

, 1989
The development of a large animal model of fulminant hepatic failure produced with acetaminophen that should be useful in the development and evaluation of potential medical therapies for the important clinical problem of fulminant hepatic failure is ...
Barone, M, Demetris, J, Francavilla, A, Makowka, L, Polimeno, L, Prelich, J, Starzl, TE, Van Thiel, DH   +7 more
core   +2 more sources

Doctor or drug dealer? International legal provisions for the legitimate handling of drugs of abuse [PDF]

, 2020
© The Author(s) 2020. The final, definitive version of this paper has been published in: Gallagher, C. T., Atik, S. K., Isse, L., & Mann, S. K. (2020). Doctor or drug dealer?
Atik, Sanaa, Gallagher, Cathal, Isse, Libin, Mann, Sanpreet   +3 more
core   +2 more sources

Role of dopamine D1 receptor in the modulation of memory consolidation by passive and self-administered heroin and associated conditioned stimuli

Scientific Reports, 2023
It has been proposed that opiates modulate memory consolidation, but recent work has indicated that this effect may be mediated by how the drug is experienced (i.e., passive injections vs. self-administration).
Travis Francis, Francesco Leri
doaj   +1 more source

Prolonged vs intermittent intravenous infusion of β-lactam antibiotics for patients with sepsis: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis

Annals of Intensive Care, 2023
Background The prolonged β-lactam antibiotics infusion has been an attractive strategy in severe infections, because it provides a more stable free drug concentration and a longer duration of free drug concentration above the minimum inhibitory ...
Xiaoming Li, Yi Long, Guixin Wu, Rui Li, Mingming Zhou, Aiting He, Zhengying Jiang   +6 more
doaj   +1 more source

Predictors of shortages of opioid analgesics in the US: Are the characteristics of the drug company the missing puzzle piece?

PLoS ONE, 2021
BackgroundShortages of opioid analgesics are increasingly common, interfere with patient care and increase healthcare cost. This study characterized the incidence of shortages of opioid analgesics in the period 2015-2019 and evaluated potential ...
Rosa Rodriguez-Monguio, Mahim Naveed, Enrique Seoane-Vazquez   +2 more
doaj   +1 more source

Naloxone interventions in opioid overdoses: a systematic review protocol

Systematic Reviews, 2019
Background North America is in the midst of an unabated opioid overdose epidemic due to the increasing non-medical use of fentanyl and ultra-potent opioids.
Lindsay Victoria Shaw, Jessica Moe, Roy Purssell, Jane A. Buxton, Jesse Godwin, Mary M. Doyle-Waters, Penelope M. A. Brasher, Jeffrey P. Hau, Jason Curran, Corinne M. Hohl   +9 more
doaj   +1 more source

Home medication management problems and associated factors among psychiatric patients using home care pharmacy services at government hospitals in western Malaysia

BMC Health Services Research, 2022
Background Proper home medication management plays a role in improving medication adherence, preserving drug efficacy and ensuring safe medication practices, which is crucial to establish positive treatment outcomes.
Christine Li Ling Lau, Cheah Yen Hor, Siew Ting Ong, Muhammad Fadhlullah Roslan, Xin Yi Beh, Dashnilatha Permal, Shamini Rama   +6 more
doaj   +1 more source

Are cocaine-seeking “habits” necessary for the development of addiction-like behavior in rats? [PDF]

, 2018
Drug self-administration models of addiction typically require animals to make the same response (e.g., a lever-press or nose-poke) over and over to procure and take drugs.
Fadanelli, Monica, Kawa, Alex B., Robinson, Terry E., Singer, Bryan F.   +3 more
core   +2 more sources

Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo

BMC Cancer, 2013
BackgroundChk1 inhibitors have emerged as promising anticancer therapeutic agents particularly when combined with antimetabolites such as gemcitabine, cytarabine or hydroxyurea.
R. Montano, Ruth Thompson, I. Chung, H. Hou, N. Khan, Alan Eastman   +5 more
semanticscholar   +1 more source