Results 141 to 150 of about 1,536,180 (350)

Fast Methods for Drug Approval: Research Perspectives for Pandemic Preparedness. [PDF]

Int J Environ Res Public Health, 2023
Abdin AY, De Pretis F, Landes J.
europepmc   +1 more source

Current Status of Clinical Trials for Approval of Anticancer Drugs in Korea and Some Guidelines [PDF]

, 2002
In‐Sook Park, Dong Seop Kim, Ki Hwan Choi, So-Young Wang, Hwa-Kyung Lim, Woo-Young Oh, Sohee Kim, Ju-Hee Kang, Yung‐Jue Bang, Joo-Il Kim   +9 more
openalex   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Current philosophical perspectives on drug approval in the real world

Journal of Causal Inference
The evidence-based medicine approach to causal medical inference is the dominant account among medical methodologists. Competing approaches originating in the philosophy of medicine seek to challenge this account.
Landes Jürgen, Auker-Howlett Daniel J.
doaj   +1 more source

Dostarlimab: From preclinical investigation to drug approval and future directions. [PDF]

Hum Vaccin Immunother, 2023
Cicala CM, Musacchio L, Scambia G, Lorusso D.   +3 more
europepmc   +1 more source

Potential conflict between fundamental ethical principles and requirements of the oncology drug approval process [PDF]

, 2003
Maurie Markman, Joseph DeMarco
openalex   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

FDA Drug Approval and the Ethics of Desperation. [PDF]

JAMA Intern Med, 2021
Largent EA, Peterson A, Lynch HF.
europepmc   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Strong Support For Sununu, Drugs Remain Most Important Problem Facing NH 5/9/17 [PDF]

, 2017
Governor Chris Sununu enjoys bipartisan approval of his job performance as well as increasing personal favorability among New Hampshire adults. A strong majority continue to believe overall the state is headed in the right direction, but for the first ...
Survey Center, UNH
core   +1 more source