Structural modeling of the hERG potassium channel and associated drug interactions
Frontiers in Pharmacology, 2022 The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go-Related Gene (hERG), is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential.
Jan Maly +12 more
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Advanced Science, 2021 Mitochondria are highly involved in the metastasis of cancer cells. However, low permeability of mitochondria impedes the entry of anti‐cancer drugs. Here, a self‐assembled nanoparticle platform is designed that not only targets the DNA‐intercalating ...
Xi Lin +6 more
doaj +1 more source
Structural modeling of hERG channel–drug interactions using Rosetta
Frontiers in Pharmacology, 2023 The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target.
Aiyana M. Emigh Cortez +17 more
doaj +1 more source
Efavirenz Loaded Nanostructured Lipid Carriers for Efficient and Prolonged Viral Inhibition in HIV-Infected Macrophages [PDF]
Pharmaceutical Sciences, 2021 Background: The clinical outcome of anti-HIV therapy is poor due to the inherent fallouts ofanti-HIV therapy. It is further worsened due to the presence of viral reservoirs in immune cellslike the macrophages.
Ketan Mahajan +4 more
doaj +1 more source
Mitochondria-Targeted Delivery of Camptothecin Based on HPMA Copolymer for Metastasis Suppression
Pharmaceutics, 2022 Poor anti-metastasis effects and side-effects remain a challenge for the clinical application of camptothecin (CPT). Mitochondria can be a promising target for the treatment of metastatic tumors due to their vital roles in providing energy supply ...
Xiaoli Yi +4 more
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Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy
Cells, 2021 The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways ...
Tianxia Lan, Li Chen, Xiawei Wei
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Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]
, 2014 Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chen, Chao-Yin +3 more
core +6 more sources
Validation of smart nanoparticles as controlled drug delivery systems: loading and pH-dependent release of pilocarpine [PDF]
, 2017 Micelles are good devices for use as controlled drug delivery systems because they exhibit the ability to protect the encapsulated substance from the routes of degradation until they reach the site of action. The present work assesses loading kinetics of
Galbis Fuster, Elsa +4 more
core +6 more sources
Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes
Pharmaceutics, 2022 The lymphatic system plays an indispensable role in humoral balance, lipid metabolism, and immune regulation. The lymph nodes (LNs) are known as the primary sites of tumor metastasis and the metastatic LNs largely affected the prognosis of the patiens. A
Zesheng Cheng +4 more
doaj +1 more source
Enhancing the Treating Efficacy of Immunotherapy through the Restructure of Tumor Microenvironment
Advanced NanoBiomed Research, 2023 The therapeutic modes of cancers have been profoundly renovated by immunotherapies, which have shown extraordinary treating efficacy in certain tumor entities.
Bokai Gong +5 more
doaj +1 more source