Structure–property relationships in ABC-type polymer carriers: exploring drug loading and release behavior via dissipative particle dynamics simulation [PDF]
RSC AdvancesThe topological architecture of polymer carriers is a critical determinant of their drug loading capacity and release characteristics. This study employed dissipative particle dynamics (DPD) simulations to systematically investigate the drug distribution
Zengwei Ma, Gaiqin Liu, Jianwei Wei
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pH-Responsive Mixed Polymeric Micelles as Gel-Related Nanocarriers for Drug Delivery: A DPD Study on Block Ratio Modulation [PDF]
GelsPolymeric micelles represent a fundamental self-assembled architecture of gel-based soft materials and have emerged as promising nanocarriers for anticancer drug delivery.
Wensheng Wu +5 more
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Structural modeling of the hERG potassium channel and associated drug interactions
Frontiers in Pharmacology, 2022 The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go-Related Gene (hERG), is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential.
Jan Maly +12 more
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Advanced Science, 2021 Mitochondria are highly involved in the metastasis of cancer cells. However, low permeability of mitochondria impedes the entry of anti‐cancer drugs. Here, a self‐assembled nanoparticle platform is designed that not only targets the DNA‐intercalating ...
Xi Lin +6 more
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Structural modeling of hERG channel–drug interactions using Rosetta
Frontiers in Pharmacology, 2023 The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target.
Aiyana M. Emigh Cortez +17 more
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Efavirenz Loaded Nanostructured Lipid Carriers for Efficient and Prolonged Viral Inhibition in HIV-Infected Macrophages [PDF]
Pharmaceutical Sciences, 2021 Background: The clinical outcome of anti-HIV therapy is poor due to the inherent fallouts ofanti-HIV therapy. It is further worsened due to the presence of viral reservoirs in immune cellslike the macrophages.
Ketan Mahajan +4 more
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Mitochondria-Targeted Delivery of Camptothecin Based on HPMA Copolymer for Metastasis Suppression
Pharmaceutics, 2022 Poor anti-metastasis effects and side-effects remain a challenge for the clinical application of camptothecin (CPT). Mitochondria can be a promising target for the treatment of metastatic tumors due to their vital roles in providing energy supply ...
Xiaoli Yi +4 more
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Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy
Cells, 2021 The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate network that consists of numerous types of cells, cytokines, enzymes and signaling pathways ...
Tianxia Lan, Li Chen, Xiawei Wei
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Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes
Pharmaceutics, 2022 The lymphatic system plays an indispensable role in humoral balance, lipid metabolism, and immune regulation. The lymph nodes (LNs) are known as the primary sites of tumor metastasis and the metastatic LNs largely affected the prognosis of the patiens. A
Zesheng Cheng +4 more
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Enhancing the Treating Efficacy of Immunotherapy through the Restructure of Tumor Microenvironment
Advanced NanoBiomed Research, 2023 The therapeutic modes of cancers have been profoundly renovated by immunotherapies, which have shown extraordinary treating efficacy in certain tumor entities.
Bokai Gong +5 more
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