Results 11 to 20 of about 1,301,601 (302)

TFAM deficiency in dendritic cells leads to mitochondrial dysfunction and enhanced antitumor immunity through cGAS-STING pathway

Journal for ImmunoTherapy of Cancer, 2023
Background Mitochondrial transcription factor A (TFAM) is a transcription factor that maintains mitochondrial DNA (mtDNA) stabilization and initiates mtDNA replication.
Yu Liu, Zhe Zhang, Min Luo, Hao Zeng, Yuquan Wei, Siyuan Chen, Xiaohe Tian, Tianqi Lu, Ziqi Zhang, Zhenfei Bi, Tianxia Lan, Fei Mo, Jingyun Yang, Xuemei He, Weiqi Hong, Ruyu Pi, Wenyan Ren, Xiawei Wei   +17 more
doaj   +1 more source

An Update on the Structure of hERG

Frontiers in Pharmacology, 2020
The human voltage-sensitive K+ channel hERG plays a fundamental role in cardiac action potential repolarization, effectively controlling the QT interval of the electrocardiogram.
Andrew Butler, Matthew V. Helliwell, Yihong Zhang, Jules C. Hancox, Christopher E. Dempsey   +4 more
doaj   +1 more source

CCL5/CCR5 axis in human diseases and related treatments

Genes and Diseases, 2022
To defense harmful stimuli or maintain the immune homeostasis, the body produces and recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among them, chemokines act as crucial regulators in defense systems.
Zhen Zeng, Tianxia Lan, Yuquan Wei, Xiawei Wei   +3 more
doaj   +1 more source

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment [PDF]

, 2020
BACKGROUND: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant
Dufès, Christine, Hewit, Kay, James, Daniel, Leung, Hing, Munnings-Tomes, Sophie, Patel, Rachana, Rushworth, Linda, Shanks, Emma, Somani, Sukrut, Straube, Anne   +9 more
core   +3 more sources

Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development

Vaccines, 2023
Vaccination is one of the most effective strategies to control epidemics. With the deepening of people’s awareness of vaccination, there is a high demand for vaccination.
Qiaonan Hong, Jian Liu, Yuquan Wei, Xiawei Wei   +3 more
doaj   +1 more source

Antifungal Resistance Analysis of Environmental Isolates of Aspergillus in North India

Journal of Pure and Applied Microbiology, 2019
Triazoles are the major group of antifungals for treating Aspergillus infections. The morbidity and mortality associated with these infections is high and rate of treatment failure is more in patients infected with azole resistant Aspergillus.
Shanu Hoda, Harshita Agarwal, Simran K. Ahluwalia, Maansi Vermani , Pooja Vijayaraghavan   +4 more
doaj   +1 more source

Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade

Frontiers in Pharmacology, 2020
Human-ether-a-go-go-related channel (hERG1) is the pore-forming domain of the delayed rectifier K+ channel in the heart which underlies the IKr current.
Meruyert Kudaibergenova, Meruyert Kudaibergenova, Jiqing Guo, Hanif M. Khan, Farhan Zahid, James Lees-Miller, Sergei Yu. Noskov, Henry J. Duff   +7 more
doaj   +1 more source

Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization [PDF]

, 2017
En route towards improved delivery systems for targeted chemotherapy, we propose a straightforward approach for the hydrophobic modification of the acrylamide N-(2-Hydroxyethyl) acrylamide (HEAm).
De Geest, Bruno, Hennink, Wim E, Kasmi, Sabah, Louage, Benoit, Nuhn, Lutz, Van Herck, Simon, van Steenbergen, Mies J, Verstraete, Glenn, Vervaet, Chris   +8 more
core   +1 more source

Inhibition of Aspergillus fumigatus Biofilm and Cytotoxicity Study of Natural Compound Cis-9- Hexadecenal

Journal of Pure and Applied Microbiology, 2019
Clinical limitations and drug-resistance are the basis of the search for new antifungal therapeutics against biofilm forming pathogen Aspergillus fumigatus.
Shanu Hoda, Lovely Gupta, Harshita Agarwal, Gaurav Raj, Maansi Vermani, Pooja Vijayaraghavan   +5 more
doaj   +1 more source

Surgical Treatment of Osteosarcoma Induced Distant Pre‐Metastatic Niche in Lung to Facilitate the Colonization of Circulating Tumor Cells

Advanced Science, 2023
Recently, the major challenge in treating osteosarcoma patients is the metastatic disease, most commonly in the lungs. However, the underlying mechanism of recurrence and metastasis of osteosarcoma after surgical resection of primary tumor remains ...
Fan Tang, Yan Tie, Tian‐Xia Lan, Jing‐Yun Yang, Wei‐Qi Hong, Si‐Yuan Chen, Hou‐Hui Shi, Long‐Qing Li, Hao Zeng, Li Min, Yu‐Quan Wei, Chong‐Qi Tu, Xia‐Wei Wei   +12 more
doaj   +1 more source