Results 131 to 140 of about 2,331,898 (261)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Evaluation of Drug Effectiveness and Controlled Release Profiles of Clay Minerals Loaded with Anti-Carcinogenic Agent as a Drug Delivery System on Leukemia

Cancer Management and Research
Mustafa Duran,1 Elif Kaga2 1Afyonkarahisar Health Sciences University Faculty of Medicine, Department of Internal Medicine, Hematology, Afyonkarahisar, Türkiye; 2Afyonkarahisar Health Sciences University Department of Medical Services and Techniques ...
Duran M, Kaga E
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Computer simulation of a pH-responsive drug delivery system formed by μ-ABC miktoarm star polymers in aqueous solution

International Journal of Smart and Nano Materials
The development of pH-responsive drug delivery systems is a critical frontier in the field of targeted cancer therapy. This study presents a comprehensive investigation into the self-assembly and drug release behavior of a pH-responsive anticancer drug ...
Zengwei Ma, Lijun Li, Nan Hu, Jianwei Wei, Lin Chen   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Chemical robotics — chemotactic drug carriers

Open Medicine, 2013
Lagzi István
doaj   +1 more source

Advanced drug delivery devices via self-assembly of amphiphilic block copolymers

Amphiphilic block copolymers are well established as building blocks for the preparation of micellar drug carriers. Over the past decade, the effectiveness of such self-assembled drug delivery devices has been demonstrated numerous times.
Vandermeulen, G.W.M., Klok, H.-A., Rösler, A.   +2 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Contribution of molecular-modified biomimetic mesoporous silica xerogel in delivering nimesulide with superior anti-inflammatory efficacy

Journal of Materials Science: Materials in Medicine
High efficiency of anti-inflammatories for anti-inflammatory drugs has enormous room for improvement, aiming to reduce side effects. Herein, molecular-modified biomimetic mesoporous silica xerogel was applied to establish a superior carrier for ...
Liu Yang, Nan Yan, Jing Li
doaj   +1 more source

Dry powder inhaler formulations : effect of carrier size on the drug dispersion [PDF]

, 2012
Background: \ud The size of the carrier influences drug aerosolization from a dry powder inhaler (DPI) formulation. Lactose particles with irregular shape and rough surface in a variety of sizes are additionally used as carriers; however, contradictory ...
Islam, Nazrul, Dargaville, Tim R., George, Graeme, Tuli, Rinku A.   +3 more
core