Results 111 to 120 of about 212,322 (308)
Journal of Materials Science: Materials in MedicineHigh efficiency of anti-inflammatories for anti-inflammatory drugs has enormous room for improvement, aiming to reduce side effects. Herein, molecular-modified biomimetic mesoporous silica xerogel was applied to establish a superior carrier for ...
Liu Yang, Nan Yan, Jing Li
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
PLGA based drug delivery systems: Promising carriers for wound healing activity. [PDF]
, 2016 Wound treatment remains one of the most prevalent and economically burdensome healthcare issues in the world. Current treatment options are limited and require repeated administrations which led to the development of new therapeutics to satisfy the unmet
Vandermeulen, Gaëlle +5 more
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Drug Delivery System, 2001 In 1975 Prof. Ringsdorf already proposed the systematic model for polymeric drugs (polymer-drug conjugates or macromolecular prodrugs), so-called “Ringsdorf's model”, aiming at enhancement and prolongation of activity of drugs, and reduced side-effects of drugs.
Yuichi Ohya, Tatsuro Ouchi
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Improved recovery of Mycobacterium tuberculosis from children using the microscopic observation drug susceptibility method. [PDF]
, 2006 OBJECTIVE: The diagnosis of pulmonary tuberculosis presents challenges in children, because symptoms are nonspecific, sputa are not accessible, and Mycobacterium tuberculosis cultures and smears often are negative.
Luz Caviedes +15 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Drug Carriers Production Processes for Innovative Human Applications [PDF]
This collection of papers describes recent advances in drug delivery systems, with a focus on nanocarriers, controlled release mechanisms, and their biomedical applications.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Preparation of pH- and thermo-sensitive chitosan-PNIPAAm core–shell nanoparticles and evaluation as drug carriers [PDF]
, 2013 Environmentally sensitive polysaccharide nanoparticles (NPs) were prepared by in situ polymerization of N-isopropylacrylamide (NIPAAm) monomer in the presence of chitosan (CS) micelles.
Huang, Chih-Hao; Wang, Cheng-Fan; Don, Trong-Ming; Chiu, Wen-Yen +1 more
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