Results 101 to 110 of about 212,322 (308)

Transporting silence: Design of carriers for siRNA to angiogenic endothelium [PDF]

, 2005
The recently developed siRNA oligonucleotides are an attractive alternative to antisense as a therapeutic modality because of their robust, gene selective silencing of drug target protein expression.
Zhou, Q., Scaria, PV, Molema, G; id_orcid, Molema, G., Advanced drug delivery systems/drug targeting, Tang, QQ, Scaria, P.V., Zhou, Q, Lu, PY, Dep Farmaceutische wetenschappen, Mixson, A.J., Xu, J., Storm, G, Mixson, AJ, Fens, MHAM, Ansari, A.M., Tang, Q., Schiffelers, R.M., Ansari, AM, Woodle, M.C., Storm, G., Dep Biologie, Universiteit Utrecht, Woodle, MC, Molema, G, Fens, M.H.A.M., Lu, P.Y.   +26 more
core   +1 more source

Unveiling the nanoworld of antimicrobial resistance: integrating nature and nanotechnology

Frontiers in Microbiology
A significant global health crisis is predicted to emerge due to antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic resistance necessitates continuous therapeutic innovation as conventional antibiotic ...
Devesh Sharma, Devesh Sharma, Sakshi Gautam, Sakshi Singh, Nalini Srivastava, Abdul Mabood Khan, Deepa Bisht   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Vesicular carriers for dermal drug delivery [PDF]

, 2009
The skin can offer several advantages as a route of drug administration although its barrier nature makes it difficult for most drugs to penetrate into and permeate through it. During the past decades there has been a lot of interest in lipid vesicles as
FADDA, ANNA MARIA, Sinico C
core   +1 more source

Aerogels: Tailor-made Carriers for Immediate and Prolonged Drug Release

KONA Powder and Particle Journal, 2014
The potential of inorganic polymeric materials – silica aerogels – as tailor-made drug carriers is discussed. It is shown that the dissolution rate of poorly soluble drugs can be significantly changed through
Irina Smirnova, Supakij Suttiruengwong, Wolfgang Arlt   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate [PDF]

, 2018
Muder Al Haydar,1,2 Hussein Rasool Abid,3,4 Bruce Sunderland,5 Shaobin Wang6 1Pharmaceutics Department, College of Pharmacy, University of Kerbala, Kerbala, Iraq; 2Pharmaceutics Department, School of Pharmacy, Faculty of Health Sciences, Curtin ...
Al Haydar M, Wang S, Sunderland B, Abid HR   +3 more
core  

Exploring Protein-Based Carriers in Drug Delivery: A Review [PDF]

Drug delivery systems (DDSs) represent an emerging focus for many researchers and they are becoming progressively crucial in the development of new treatments.
Francesco Patitucci, Sabrina Prete, Ortensia Parisi, Giuseppe Scopelliti, Francesco Puoci, Marco Dattilo, Claudia Ferraro   +6 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model [PDF]

, 2012
Background: The blood-brain barrier (BBB) represents an insurmountable obstacle for most drugs thus obstructing an effective treatment of many brain diseases.
Tikva Vogel, Zensi, Anja, von Briesen Hagen, Kreuter Jörg, Worek Franz, Tschickardt, Sabrina E., Sascha L Wien, Jörg Kreuter, Wien Sascha L., Vogel Tikva, Sabrina E Tschickardt, Wladislaw Maier, Vogel, Tikva, Sylvia Wagner, Claus U Pietrzik, Maier Wladislaw, Zensi Anja, Wien, Sascha L., Maier, Wladislaw, Tschickardt Sabrina E., Wagner, Sylvia, Pietrzik Claus U., Anja Zensi, Kreuter, Jörg, Worek, Franz, Hagen von Briesen, Pietrzik, Claus Ulrich, Briesen, Hagen von, Wagner Sylvia, Franz Worek   +29 more
core   +1 more source