Results 81 to 90 of about 2,202,442 (302)
Efficient integration and fast excretion of drug carrier: The trojan horse for cancer therapy
Smart Materials in Medicine, 2020 Macromolecular engineering has benefited the fabrication of drug delivery systems, owing to the versatile and tunable physical and chemical properties of the polymeric carriers as needed. However, the slow excretion rate of the macromolecule carriers has
Wang Zhen, Wenguo Cui
doaj +1 more source
Colloidal carriers for ophthalmic drug delivery
, 2005 To achieve effective drug concentration at the intended site for a sufficient period of time is a requisite desired for many drug formulations. For drugs intended to ocular delivery, its poor bioavailability is due to pre-corneal factors.
Cinto, P. O. +7 more
core +1 more source
Engineering the drug carrier biointerface to overcome biological barriers to drug delivery [PDF]
, 2020 Micro and nanoscale drug carriers must navigate through a plethora of dynamic biological systems prior to reaching their tissue or disease targets.
Finbloom, Joel A +3 more
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Evaluation of the Peer Support Program (Student Drug Prevention) 1986-1987
, 2019 The Peer Support program is a school based program funded by the National Campaign Against Drug Abuse (NCADA) as a drug prevention strategy. Prior to the existence of the NCADA the program was funded through the NSW Drug and Alcohol Authority.
Directorate of the Drug Offensive
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Frontiers in Oncology, 2018 Glioblastoma, the most common, aggressive brain tumor, ranks among the least curable cancers—owing to its strong tendency for intracranial dissemination, high proliferation potential, and inherent tumor resistance to radiation and chemotherapy.
Drazen Raucher +2 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Unveiling the nanoworld of antimicrobial resistance: integrating nature and nanotechnology
Frontiers in MicrobiologyA significant global health crisis is predicted to emerge due to antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic resistance necessitates continuous therapeutic innovation as conventional antibiotic ...
Devesh Sharma +6 more
doaj +1 more source
An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei [PDF]
, 2015 Elucidating the mechanism of action of trypanocidal compounds is an important step in the development of more efficient drugs against Trypanosoma brucei. In a screening approach using an RNAi library in T. brucei bloodstream forms, we identified a member
Vial, Henri +28 more
core +3 more sources