Results 71 to 80 of about 2,331,898 (261)
Engineering antiphagocytic biomimetic drug carriers
, 2013 Drug-delivery carriers have the potential to not only treat but also diagnose many diseases; however, they still lack the complexity of natural-particulate systems.
Sawdon, Alicia J., Peng, Ching An
core +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Frontiers in Oncology, 2018 Glioblastoma, the most common, aggressive brain tumor, ranks among the least curable cancers—owing to its strong tendency for intracranial dissemination, high proliferation potential, and inherent tumor resistance to radiation and chemotherapy.
Drazen Raucher +2 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Unveiling the nanoworld of antimicrobial resistance: integrating nature and nanotechnology
Frontiers in MicrobiologyA significant global health crisis is predicted to emerge due to antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic resistance necessitates continuous therapeutic innovation as conventional antibiotic ...
Devesh Sharma +6 more
doaj +1 more source
An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei [PDF]
, 2015 Elucidating the mechanism of action of trypanocidal compounds is an important step in the development of more efficient drugs against Trypanosoma brucei. In a screening approach using an RNAi library in T. brucei bloodstream forms, we identified a member
Vial, Henri +46 more
core +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Aerogels: Tailor-made Carriers for Immediate and Prolonged Drug Release
KONA Powder and Particle Journal, 2014 The potential of inorganic polymeric materials – silica aerogels – as tailor-made drug carriers is discussed. It is shown that the dissolution rate of poorly soluble drugs can be significantly changed through
Irina Smirnova +2 more
doaj +1 more source
Efficient integration and fast excretion of drug carrier: The trojan horse for cancer therapy
Smart Materials in Medicine, 2020 Macromolecular engineering has benefited the fabrication of drug delivery systems, owing to the versatile and tunable physical and chemical properties of the polymeric carriers as needed. However, the slow excretion rate of the macromolecule carriers has
Wang Zhen, Wenguo Cui
doaj +1 more source
Colloidal carriers for ophthalmic drug delivery
, 2005 To achieve effective drug concentration at the intended site for a sufficient period of time is a requisite desired for many drug formulations. For drugs intended to ocular delivery, its poor bioavailability is due to pre-corneal factors.
Cinto, P. O. +8 more
core +1 more source