Results 91 to 100 of about 2,200,984 (302)
Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk [PDF]
, 2013 BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were Side, Lucy E.,, Investigators, k, Pastinen, Tomi, Van Os, Theo A.M., D. F. Easton (7608179), J. Balmana, Ute Hamann (89879), Volorio, Sara, A. Lasa, SWE-BRCA, Tihomirova, L, Imyanitov, E.N., Moeller, ST, L. Senter, Friedlander, M., Muy-Kheng Tea, Barrowdale, D., Öfverholm, Anna, Aittomaki, K., N. Tung, J. Lester, C. F. Singer (7619636), T. Huzarski (7676663), Douglas, F., Shimon Paluch, Shani,, Frans B L Hogervorst, Barkardottir, Rosa B, C. Houdayer (7658699), Pascal Pujol, Dreyfus, Hélène, H. Thorne, Murday, Victoria, Viel, Alessandra, Heli Nevanlinna, Rouleau, E, Shani Shimon Paluch (395262), Yuan Chun Ding (322601), de la Hoya, Miguel, P. Pujol, Capucine Delnatte (395234), Georgia Chenevix-Trench (361), Rita Katharina Schmutzler (395199), Paolo Peterlongo, Kerstin Rhiem (112049), Imyanitov, Evgeny N., Z. Miedzybrodzka, Bonanni, Bernardo, C. Lazaro, Adam Lee, Beattie, Mary S.,, Arnold, N, Caldes, Trinidad,, Dezheng Huo (151859), Sinilnikova, O. M., Pascaline Berthet (395233), J. Garber (7608110), Chung, Wendy K., Arver, Brita, Zachary Fredericksen (146612), Diana M. Eccles (219472), Pujol, P, Sand, S, A. E. Toland (7608026), Niederacher, D, A. Lucassen, Lubinski, Jan, D. E. Cohn (7676702), Tihomirova, L., Miguel de la Hoya, D. Gareth Evans (154186), Ausems, M. G E M, T. Pastinen (7608953), Marco Montagna (238698), Berthet, Pascaline, Taylor, Jane, L. Venat Bouvet, A. Meindl (7619555), Slager, Susan L, B. Bonanni (1681321), Weber, Bernhard HF, Brewer, C., Mulligan, A.M., Sabine Preisler-Adams (395251), Bernhard H. F. Weber (162289), Osorio, A, Hardouin, A, Pastinen, T., Peissel, Bernhard, Kristiina Aittomäki, Esther M John, Mazoyer, S, Friebel, T, Lidereau, Rosette, Blanco, I, Jonson, L, Gaudet, Mia M.,, Patrick J Morrison, Lee, A, Christian F. Singer (308365), Platte, Radke, M. C. Southey (7608080), Lenka Foretova (162255), Platte, Radka, Liljegren, Annelie, Huzarski, Tomasz, Tibiletti, MG, Lebrun, Marine, K. Kohut, Spurdle, Amanda B, Y. Laitman (7608005), Pujol, Pascal,, Ewart Toland, A., M. Tischkowitz, Alexandra V. Stavropoulou (387774), O. Caron, C. Seynaeve, S. V. Blank, Jan Lubinski (59925), C. M. Kets, Berthet, P., L. Snadden, Daphne Gschwantler-Kaulich, A. Romero (3572522), J. Benitez, Wijnen, JT, Singer C.F., Guimbaud, Rosine, Susan L Neuhausen, Frans B. L. Hogervorst (146390), D. Frost, Mortemousque, Isabelle, Coupier, Isabelle,, F. Prieur, et al., Ignacio Blanco, Donaldson, A, M. Lebrun, E. Castro, A. M. Mulligan, Peissel, Bernard,, Fredericksen, Z, Pujana, Miquel Angel, Zakaria Einbeigi, Andrea Gehrig, Stoppa-Lyonnet D., Eeles, RA, Teo, Soo-Hwang,, M. J. Blok, C. Nogues (2482849), E. Niedermayr, Handallou, Sandrine, Wiggins, Jennifer, Kwong, A., Varon-Mateeva, R, Olopade, O.I., C. Engel (7619549), R. Platte (7608131), Kruse, Torben A, Maria Grazia Tibiletti (395246), Cunningham, Julie, Leone, Melanie,, S. Hart, Kristiina Aittomäki (89889), Kuchenbaecker, K. B., Montagna, M., Tomasz Huzarski, Dennis, Joe,, Robson, Mark,, A. Gehrig (7676681), van Asperen, C. J., K. Jaworska, Gadzicki, D., Mette K. Andersen (395271), Lindor, Noralane M, David E Cohn, Vincent, Daniel,, Pankratz, Vernon S, Mia M. Gaudet (146621), Soucy, Penny, E. Fineberg (7658291), Blok, Marinus J.,, Raymonda Varon-Mateeva, S. A. Narod, Rouleau, Etienne,, G. Glendon, Jernström, Helena, Sokolowska, Johanna, Moeller, S, Pujana, M.A., Uhrhammer, Nancy, Haque, Eshika, Buys, SS, Kruse, T.A., Ligtenberg, Marjolijn JL, Vijai, Joseph,, D. Mcbride, T. M. Friebel, M. K. Tea (7619639), Robson, Mark, S. M. Domchek, Sue Healey, A. Murray, Gerdes, Anne-Marie, Jaworska, Katarzyna,, Kara Sarrel, Douglas, Fiona,, Hall, Per, Rookus, M. A., L. Foretova (7676744), S. R. Sand, Lindblom, Annika, Laurie Small, Toulas, Christine, A. M. Dunning (7658231), Adlard, Julian,, Ottini, Laura,, Verhoef, S, Janavicius, R, R. Rosenquist (7652192), Prieur, Fabienne, Nogues, Catherine, S. T. Moeller, Hodgson, Shirley,, Morrison, Patrick J., L. E. Side, D. Huo (7676804), Godwin, Andrew K, C. Toulas, Christian Sutter, J. Adlard (7619510), Meindl, A, Hart, Steven,, Shimon Paluch, S, Mai, Phuong L, F. Bacot (7658246), F. Prieur (7658807), Venat-Bouvet, Laurence,, Szabo, C.I., Kathleen Claes (203063), G. Pfeiler (7658321), Goldgar, David E, Os, T.A. van, Sharon R Sand, Evans, Gareth; id_orcid, Ehrencrona, Hans, Susan J Ramus, A. Donaldson (6262271), Kruse, T, A. Hardouin, Sharon R. Sand (395278), Karin Kast (112042), H. T. Lynch, Barkardottir, R, Z. Fredericksen (7619612), Andersen, MK, Southey, Melissa C., Jaworska, K., Gaudet, MM, Ligtenberg, MJL, Jocelyne Chiquette, M. Porteous, Lars Jønson (395270), Inge Sokilde Pedersen, Tara M. Friebel (395289), A. P. Sokolenko (7676810), Isabelle Coupier (292499), S. Goff, M. J. Blok (7658489), Rosa B Barkardottir, O. Diez (7676606), Ellis, S, Drummond, Sarah, Anna Marie Mulligan (146672), Gerdes, Anne-Marie,, Domchek, SM, Izatt, Luise, Douglas F. Easton (89956), Catherine M. Phelan (219497), Traasdahl Moeller, Sanne, Frans B. L. Hogervorst, L. Varesco (7676669), Melissa C Southey, Os, T. A.,, Christine Lasset, Laurence Venat-Bouvet (395240), Mélanie Léoné (395241), Sinilnikova O.M., S. Goodman, Bubien, Virginie, N. Tung (7608077), Tung, Nadine,, K. Sarrel, Paluch, Shani Shimon, Muranen, TA, Ausems, M.G., Marc Tischkowitz, Szabo, Csilla I, G. Dite, Jacqueline Eason, Hogervorst, F.B., Gomez Garcia, E.B., L. Side, Laurie Small (395257), A. K. Godwin (7608119), Tibiletti, M, I. Blanco, K. Rhiem (7619546), Laitman, Y., Borg, Åke, Kosel, Matthew, Sutter, C., M. G. E. M. Ausems, Anne-Marie Gerdes, S. Preisler Adams, Stefanie Engert (112037), A. V. Stavropoulou (7676780), Chen, Wang, Finn C Nielsen, V. S. Pankratz, Piedmonte, Marion,, V. Bubien, Gibson, Sarah, Coupier, I., N. Ditsch, Hogervorst, Frans B L, M. Leone, K. Durda (7676657), Mads Thomassen, Ellis, Ian, Meindl, Alfons,, Dicks E., Wendy K Chung, M. Soller, Mazoyer, S., Devilee, Peter,, Pastinen, Tomi,, B. Arver (7619687), Gadzicki, D, Jakubowska, Anna,, Searle, Anne, Alexander Miron (28179), J. Cunningham (7676831), C. Jacobs, Fergus J Couch, A. De Pauw, S. B. Chan, Eitan Friedman (196582), Hansen, TV, Rensburg, E. J.,, McLeod, Diane, Neuhausen, Susan L.,, Alison M. Dunning (146796), Terry, MB, M. Piedmonte, Złowocka-Perłowska, Elżbieta, Hansen, TVO, S. L. Slager, Vijai, Joseph, Antoniou, AC, Dorfling, C.M., L. E. Side (7619534), T. Noguchi, Złowocka-Perlowska, Elz bieta, Pujol, Pascal, Olswold, C, S. Giraud, Hansen, T.V.O., Ava Kwong (52115), J. Simard, Feillel, Viviane, Antoniou, A., Nogues, C., Mary S Beattie, Domchek, S, Adlard, Julian, M. B. Daly (7608074), Laitman, Yael,, Frost, D, Silvia Tognazzo (395279), D. Stoppa-Lyonnet (7608194), S. J. Ramus (7608041), Neuhausen, S, Cook, J., M. K. Schmidt, Wang, Xianshu, Ottini, L, Blank, Stephanie V., Karlan, BY, B. Peissel (7619426), J. De Lange, Schmutzler, R. K., Benitez, Javier, Papi, L., F. E. van Leeuwen (7658432), Grazia Tibiletti, Maria,, Ontario Canc Genetics Network, Volorio, S., T. C. T. E. F. Van Cronenburg, Lee, A., Kristoffersson, Ulf, Lenka Foretova, Nielsen, FC, Jonson, L., A. Osorio (7608089), Miquel Angel Pujana (395274), Finn C. Nielsen (206969), Mulligan, AM, Dieter Niederacher (93623), Teo, S.H., Slager, SL, H. Ozcelik (7608029), Angel Pujana, Miquel, EMBRACE (Epidemiological Study of Familial Breast Cancer), Pascal Pujol (8444), Sandra Orsulic, G. Rea, P. Hall (7508258), Izatt, Louise, Huo, D., Southey, M. C., Kaufman, B, Pensotti, Valeria, Jenny Lester (395276), Pfeiler, Georg, Beth Y. Karlan (184236), Sutter, C, Kientz, Caroline, Manoukian, Siranoush,, Longmuir, Mark, T. M. Friebel (7676819), Ganz, P.A., M. J. Kennedy, N. Loman (7676693), Weaver, Joellen, T. Huzarski, E. Olah, S. Hodgson (7633343), Stephanie V Blank, Bernhard H F Weber, Sokolenko, Anna P., Huo, DZ, Houghton, Catherine,, Ontario Cancer Genetics Network, Durda, K., J. T. Wijnen (7658285), C. Rappaport (7676717), Teule, Alex, Hamann, Ute, Pujana, MA, Singer, Christian F, Norbert Arnold, Dennis, Joe, H. Nevanlinna, S. Shimon Paluch (7676723), Rouleau, Etienne, Theo A. M. van Os (395220), Peissel, Bernard, Blanco, I., Buys, S, Stenmark-Askmalm, M., H. Gregory, Miron, A., Orsulic, Sandra,, Ganz, PA, Narod, S.A., Nadine Tung (238710), Ramus, S.J., van Rensburg, Elisabeth J., N. Sevenet, B. H. Weber (7676690), J. Dennis (7658234), Gregory, Helen,, Annemarie H van der Hout, Alexander Miron, Chun Ding, Yuan, C. H. van Deurzen (7676618), Kruse, Torben A.,, Y. C. Ding (7619387), Weaver, J, Flora E. van Leeuwen (248404), Raymonda Varon-Mateeva (196729), van Os, Theo AM, Ramus, Susan J, E. Rouleau (7658759), Noah Kauff, Rosenquist, Richard,, Blok, M.J., E. B. Gomez Garcia, Lasset, C, C. Berlin, Cohn, D.E., Caroline Seynaeve, Arun, Banu K, Trinidad Caldes, Soucy, Penny,, van Leeuwen, Flora E, S. B. Chan (7676807), Hall, P., van Deurzen, C, Walsh, C, Jeffrey N. Weitzel (238722), Francesca Damiola, Soller, Maria, Hansen T.V.O., N. Kauff (7619633), Joe Dennis, Agnès Hardouin, Hansen, Thomas VO, Engert, Stefanie, K. Offit, B. H. F. Weber, L. Izatt (7608137), M. K. Andersen, Vincent, D., Mary Beth Terry (2801), Karin Kast, Friedman E., J. P. Fricker, Huw Dorkins, Olufunmilayo I. Olopade (151873), Aittomäki, K, Hogervorst, FB, Hilmi Ozcelik (20185), Huo, Dezheng, Stenmark-Askmalm, M, S. H. Teo (7675199), Pedersen, IS, M. Belotti, Bent Ejlertsen, Teule, A., Encarna B. Gómez Garcia (5654410), Olah, E., C. M. Phelan, Jacqueline Eason (238727), Montagna, M, I. S. Pedersen (7676726), Ejlertsen, B, E. Friedman (7608035), Anneliese Fink-Retter, L. Foretova, Friedman, Eitan,, Peterlongo, Paolo,, Beattie, MS, Engert, Stefanie,, Spurdle, Amanda B.,, Steven A. Narod (230773), E. N. Imyanitov (7676600), Jackie Cook, al., et, Rosalind A Eeles, K. Henriksson, Rebbeck, Timothy R.,, van Deurzen, Carolien H. M., F. B. Hogervorst (7608212), Wijnen, J.T., Barbara Wappenschmidt, Meindl, Alfons, Eitan Friedman, Blank, Stephanie V, S. Shimon Paluch, Timothy R. Rebbeck (230766), Lazaro, Conxi, Olah, E, Radice P., Zlowocka-Perlowska, E, Jensen, U, Agata, S, Orsulic, S., Ejlertsen, Bent,, F. Douglas (7658597), Kristen Stevens, Eason, J, Soucy, P., B. Bressac De Paillerets, James, Margaret, Paolo Radice (146601), E. Zlowocka Perlowska, Gille, JJP, Hansjoerg Plendl (395250), Złowowcka-Perłowska, Elzbieta, L. Small, Ausems, Magreet G. E. M., Paluch, SS, Friebel, TM, Conxi Lazaro (3405329), Daly, Mary B.,, Vaszko, T, C. Sutter, Agnès Hardouin (395232), Friebel, T.M., Preisler-Adams, S., Glendon, Gord, Greene, M.H., Marinus J. Blok (395217), Nevanlinna, H., Hoya, M. de la, Yves-Jean Bignon (54433), I. L. Andrulis (7608020), von Wachenfeldt, Anna, Lars Jønson, Sutter, Christian,, McGuffog, Lesley, Karlan, B. Y., Fabienne Prieur (246641), Lazaro, C (Conxi), Hilmi Ozcelik, Bacot, Francois,, Collaborators, GEMOS, Bourdon, Violaine, Lee, Andrew, Jensen, UB, Herzog, J, Bacot, Françios, Lucassen, Anneke, Simard, Jacques,, Friedlander, Michael, Theo A M van Os, Xianshu Wang (146610), Olga M Sinilnikova, Steele, L, Waisfisz, Q., Platte, R, Lubinski, Jan,, C. Tirapo, Meijers-Heijboer, H. E., Bacot, F., Blank, SV, A. Calender, Singer, CF, Joan Brunet (75020), M. Kosel (7676585), A. Brady, Hanne E J Meijers-Heijboer, Einbeigi, Z, Blanco, Ignacio, A. P. Sokolenko, Penny Soucy (21792), Andrulis, IL, Steele, L., Weber, B.H., Caroline Seynaeve (95368), Singer, Christian F.,, S. M. Domchek (7608044), Evans, Gareth D., Loud, J.T., Domchek S.M., Anne-Bine Skytte (395263), Hart, Steven, Rappaport, C, Szabo, C. I., M. Emanuelsson, Tea, Muy Kheng, Gille, JJ, J. Paterson, Ausems, Margreet GEM, Ava Kwong, Judith Balmaña (395210), Demange, Liliane, Goldgar, D, Ramus, Susan J., Thomas V O Hansen, Sylvie Mazoyer, S. Manoukian, Dorfling, CM, Loman, N., N. M. Lindor (7619618), Preisler-Adams, Sabine, Pankratz, V.S., Martin, Sue, Hansen, Thomas V O, Goldgar, DE, N. M. Lindor, Sobol, Hagay, Easton, D.F., O. I. Olopade (7607978), Castera, L., Sabine Preisler-Adams, Cunningham, J, O. I. Olopade, Jonson, Lars,, S. Agata, C. Houghton, J. T. Loud, Chenevix-Trench, G., Curtis Olswold (73571), Kulkarni, Anjana, Ausems, MGEM, Sinilnikova, O.M., J. Chiquette, Glendon, G, Ding, Y.C., S. Tognazzo (7619591), Imyanitov, EN, Wang X., Anneliese Fink-Retter (395258), M. H. Greene (7608092), Muranen, T.A., J. Herzog (7676765), Ellis, Steve,, S. Handallou, kConFab Investigators, C. Lasset, M. Stenmark Askmalm, Fournier, Joëlle, Montagna, Marco,, Christoph Engel, Edith Olah (395204), Bignon, Y, Kets, C. M., D. Yannoukakos, J. Maskiell, C. Brewer (7658534), Kenneth Offit (63812), van Rensburg, E, Kauff, N., D. Frost (7608128), Ausems, M.G.E.M., Lehmann, Anna, X. Wang (770484), A. Ewart Toland, Garcia, EBG, Andrulis, Irene L, V. L. Bae-Jump (7676714), Zachary Fredericksen, Elena Fineberg, Side, Lucy, Prieur, Fabienne,, Carole Brewer, Senno Verhoef (395219), T. A. Kruse (6179165), de Pauw, Antoine, HEBON (Hereditary Breast and Ovarian Cancer Research Group Netherlands), Dunning, A.M., Karlan, Beth Y, Piedmonte, M, A. Osorio, E. Kivuva, Orsulic, Sandra, van Rensburg, EJ, Moeller, S.T., J. M. Collee, van Leeuwen, F.E., Stormorken, Astrid, Marc Tischkowitz (395208), A. V. Stavropoulou, Josef Herzog (395277), Osorio, Ana, Soo-Hwang Teo (266270), Offit, Kenneth, Dicks, Ed,, Hogervorst, F. B L, Ozcelik, Hilmi,, Vaszko, Tibor, Murray, Alexandra, Debra Frost, Stevens, Kristen,, Orland Diez (395209), Phuong L. Mai (238716), Ramus, Susan J.,, Mercedes Duran, van Rensburg, E.J., Sobol, Hagay,, D. Vincent (2350123), Janavicius, Ramunas, Barrowdale, D, Brady, Angela, Beattie, M, Jaworska, K, Steve Ellis, P. A. Ganz (7619606), Kast, K., A. B. Skytte, Spurdle, AB, Soucy, P, Chung, W.K., Sarrel, Kara,, D. E. Cohn, Gaudet, M. M., Beattie, M. S., Elena Fineberg (395222), Senter, L, P. Peterlongo, F. Soubrier, Hagay Sobol, Evans, DG, Healey S., Ardern-Jones, Audrey, Sara Volorio (255289), Nadine Tung, Prieur, F, Joe Dennis (395193), S. Smalley, Nathanson, Katherine L.,, Hamann, Ute,, Rookus, Matti A.,, Valeria Pensotti (395247), S. Mazoyer, Weber, BHF, A. Melville, Josef Herzog, Nina Ditsch, Terry, M. B., K. Kast (7619507), Phelan, Catherine M.,, Neuhausen, Susan L., de Lange, J., Christian Sutter (196732), Miron, A, Mercedes Duran (5651374), Bignon, Yves-Jean,, Olufunmilayo I Olopade, Greene, Mark H.,, Agata, S., Isabelle Coupier, Gille, Johannes J.P., J. T. Wijnen, Mulligan, A, Engel, Christoph,, Hodgson, Shirley, Melin, Beatrice, Shirley Hodgson, Alex Murray (395230), L. Tihomirova (7676816), Fineberg, E., Antoniou, Antonis C, Andrew Lee (74302), C. Delnatte, A. Liljegren, Dorfling, Cecilia M.,, M. Piedmonte (7607933), Rogers, M.T., Paterson, Joan, Hogervorst, FBL, M. Duran, L. Winchester, Dennis, J, K. Hill, Thomassen, Mads,, K. Kast, N. Rahman, van Leeuwen, F. E., Capucine Delnatte, Nielsen, F, BCFR, Mazoyer, Sylvie,, M. Gauthier Villars, Trinidad Caldes (3147195), Gaudet, Mia M, Evgeny N Imyanitov, M. G. Tibiletti, Venat-Bouvet, L, K. Aittomaki, Gerdes, A.-M., Angel Pujana, Miquel,, Richard Rosenquist (262592), Stavropoulou, Alexandra V., Side, Lucy E., Mary B. Daly (196724), M. A. Pujana (7676753), Kruse, TA, Tihomirova, Laima, Mourits, M. J., Preisler-Adams, S, James, Paul A, Richard Rosenquist, Weitzel, Jeffrey N, Faivre, Laurence, Ellis, Steve, Leone, M., Kenneth Offit, M. B. Daly, Mai, P.L., Kuchenbaecker, Karoline B.,, Walker, Lisa, V. Attard, Marion Piedmonte, Eeles, R. A., B. Stayner, Jeffers, Lisa, L. Castera (7676645), Susan M. Domchek (154078), Murray, Alex,, J. Rantala, B. Buecher, Drakoulis Yannoukakos (4758), K. Harbst, A. Remenieras, J. N. Weitzel (7608107), Mia M. Gaudet, A. Jakubowska (7658414), Nathanson, K.L., Robson, M., Easton, Douglas F, J. Gronwald (7676654), Christian F Singer, Morrison, P.J., R. Davidson, Chenevix-Trench, G, Teule, Alex,, Phelan, C, Marion Piedmonte (238646), Ditsch, Nina,, Teo, Soo-Hwang, Matthew Kosel, Lester, Jenny,, Norbert Arnold (112045), K. Stevens (4256824), Eccles, DM, Plendl, Hansjoerg, M. B. Terry (7608047), Arver, B., I. S. Pedersen, Gauthier-Villars, Marion, F. Douglas, Gustavo C Rodriguez, K. B. Kuchenbaecker (7658228), Cohn, David E.,, Peter Devilee, McGuffog, Lesley,, Gehrig, A, Dominique Stoppa Lyonnet, E. J. van Rensburg (7658273), A. M. W. Van Den Ouweland, Olswold, Curtis,, Meijers-Heijboer, Hanne EJ, Einbeigi, Zakaria,, Dorkins, Huw,, Healey, S., Schmutzler R.K., Jacques Simard, Rodriguez, Gustavo C, Susan J. Ramus (205214), Devilee, Peter, Tripathi, Vishakha, Bignon, Y.J., Taru A. Muranen (395284), Karlan, B, Vincent, D, van Rensburg, Elizabeth J, Peissel, B., Hagay Sobol (91961), Daly, M. B., S. Preisler-Adams (7619522), Gehrig, Andrea,, Leroux, Dominique, Tischkowitz, M., C. E. Ardnor, Aalfs, C. M., Glendon, G., Lindor, Noralane M.,, Fergus J. Couch (146607), Angel Pujana, M., M. S. Beattie, B. A. Agnarsson (7676822), Lasset, Christine, T. R. Rebbeck, Blanco, Ingnacio, Stenmark-Askmalm, Marie, Castro, Elena, Louise Izatt, N. Ditsch (7676684), Kosel, M, Sara Volorio, Dorfling, Cecilia M, Antonis C. Antoniou (146788), David E. Cohn (395255), Damiola, Francesca, Andersen, M, Lasa, Adriana, G. Crawford, Mary S. Beattie (395206), Rouleau, E., Amanda Ewart Toland (164514), Katarzyna Jaworska (146755), Balmana, J., Durda, Katarzyna,, Couch, Fergus J., SWE-BRCA (7619690), Buys, Saundra S., Ramus, SJ, A. Searle, B. Bonanni, Remenieras, Audrey, R. B. Barkardottir, Houghton, C, Laitman, Y, J. Cunningham, Douglas, Fiona, Yannoukakos, D, S. Volorio, Karoline B. Kuchenbaecker (395191), Szabo, C, D. Eccles, Loud, Jennifer T, Georgia, Chenevix-Trench, Houlston, Richard, Montagna, Marco, Duran, M, Hamann, U., van Os, Theo A. M. +999 morecore +4 more sourcesStructure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.Alex J. Vecchiowiley +1 more sourceCharacterization of HIF‐1α/Glycolysis Hyperactive Cell Population via Small‐Molecule‐Based Imaging of Mitochondrial Transporter Activity
Advanced Science, 2018 The characterization of cancer stem‐like cells (CSCs) has profound implications for elucidating cancer biology and developing treatment strategies.Yang Wang, Xingyun Liao, Jianguo Sun, Bin Yi, Shenglin Luo, Tao Liu, Xu Tan, Dengqun Liu, Zelin Chen, Xin Wang, Chunmeng Shi +10 moredoaj +1 more sourceComprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells
Journal of Extracellular Vesicles, 2017 Extracellular vesicles (EVs) are under evaluation as therapeutics or as vehicles for drug delivery. Preclinical studies of EVs often use mice or other animal models to assess efficacy and disposition.Xiaohua Zhu, Mohamed Badawi, Steven Pomeroy, Dhruvitkumar S. Sutaria, Zhiliang Xie, Alice Baek, Jinmai Jiang, Ola A. Elgamal, Xiaokui Mo, Krista La Perle, Jeffrey Chalmers, Thomas D. Schmittgen, Mitch A. Phelps +12 moredoaj +1 more sourceLigand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada +5 morewiley +1 more source
