Results 91 to 100 of about 211,400 (307)
Aerogels: Tailor-made Carriers for Immediate and Prolonged Drug Release
KONA Powder and Particle Journal, 2014 The potential of inorganic polymeric materials – silica aerogels – as tailor-made drug carriers is discussed. It is shown that the dissolution rate of poorly soluble drugs can be significantly changed through
Irina Smirnova +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Drug Delivery System, 2001 In 1975 Prof. Ringsdorf already proposed the systematic model for polymeric drugs (polymer-drug conjugates or macromolecular prodrugs), so-called “Ringsdorf's model”, aiming at enhancement and prolongation of activity of drugs, and reduced side-effects of drugs.
Yuichi Ohya, Tatsuro Ouchi
openaire +2 more sources
Unveiling the nanoworld of antimicrobial resistance: integrating nature and nanotechnology
Frontiers in MicrobiologyA significant global health crisis is predicted to emerge due to antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic resistance necessitates continuous therapeutic innovation as conventional antibiotic ...
Devesh Sharma +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Combination of drugs and carriers in drug delivery technology and its development
, 2019 Ying Du, Baoan ChenDepartment of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of ChinaAbstract: The development of drug-loading technology will bring new and rapid development to ...
Du Y, Chen B
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Journal of Materials Science: Materials in MedicineHigh efficiency of anti-inflammatories for anti-inflammatory drugs has enormous room for improvement, aiming to reduce side effects. Herein, molecular-modified biomimetic mesoporous silica xerogel was applied to establish a superior carrier for ...
Liu Yang, Nan Yan, Jing Li
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Drug targeting to tumors using HPMA copolymers
, 2009 Copolymers based on N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized polymeric drug carriers that have been broadly implemented in the delivery of anticancer agents.
Dep Farmaceutische wetenschappen +2 more
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