Results 41 to 50 of about 415,670 (364)

Channel Responses for the Molecule Release from Spherical Homogeneous Matrix Carriers [PDF]

arXiv, 2021
Molecular communications is a promising framework for the design of controlled-release drug delivery systems. Under this framework, drug carriers, diseased cells, and the channel are modeled as transmitters, absorbing receivers, and diffusive channel, respectively. In this paper, we investigate diffusion-based spherical matrix-type drug carriers, which
arxiv  

Effects of Hydrophilic Carriers on Structural Transitions and In Vitro Properties of Solid Self-Microemulsifying Drug Delivery Systems

Pharmaceutics, 2019
Self-microemulsifying drug delivery systems (SMEDDS) offer potential for improving the oral bioavailability of poorly water-soluble drugs. However, their susceptibilities during long term storage and in vivo precipitation issues limit their successful ...
Tao Yi, Jifen Zhang
doaj   +1 more source

Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release [PDF]

, 2011
Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug ...
A Al-Omar, A Latrofa, A Miro, A Trapani, A Vyas, AC Jain, AK Upadhyay, AL Nielsen, AS Hoffman, B Haeberlin, B Pose-Vilarnovo, BN Naidu, C Cannavà, C Rodriguez-Tenreiro, C Rupp, C-Y Chen, Catarina Carvalho, Claúdia Conduto, CM Buchanan, CM Fernandes, D Duchêne, D Duchêne, EA Zannou, EY Kim, F Frézard, F Hirayama, G Corti, G Gladys, G Pescitelli, G Trapani, G Wenz, G Zingone, GL Amidon, H Blode, H Hamada, H Matsuda, H Namazi, H Taira, H Yano, HA Archontaki, Helena M. Cabral Marques, HH Sigurdsson, HS Ganapathy, HS Woldum, Inês Sanches, IV Terekhova, J Cheng, J Králová, J Savolainen, J Szejtli, J Szejtli, J Xiong, JJ García-Rodriguez, João Arrais, JP Venter, JR Moyano, JS Smith, JW Wong, K Dua, K Minami, K Motoyama, K Nakanishi, K Okimoto, K Okimoto, K Okimoto, K Terao, K Udo, K Uekama, K Uekama, K Uekama, K-H Frӧmming, KP Chowdary, L Ribeiro, L Szente, L Trichard, M Agüeros, M Agüeros, M Charoenchaitrakool, M Cirri, M Echezarreta-López, M Fukuda, M Jug, M Jug, M Kamada, M Prabaharan, M Roux, M Sauceau, M Temtem, M Türk, M Usuda, M Yoshinari, M-J Zou, ME Zugasti, MT Esclusa-Díaz, MZI Khan, N Mourtzis, N Patel, N Zerrouk, N Zhang, N Özdemir, P Jansook, P Mura, P Mura, P Mura, P Mura, P Mura, Patrícia Pontes, Paulo José Salústio, PJ Salústio, R Cavalli, R Cavalli, R Challa, R Ficarra, R Garg, R Stancanelli, RL Carrier, S Petralito, S Péroche, S Sajeesh, S Sotthivirat, S Sotthivirat, S Szejtli, S Tommasini, S-Y Lee, Shishu, SM Badr-Eldin, T Endo, T Higashi, T Higashi, T Irie, T Loftsson, T Loftsson, T Loftsson, T Vasconcelos, T Yamanoi, V Burckbuchler, V Lemesle-Lamache, VM Rao, W Ling, W Sajomsang, X Lu, X Wen, X-M Liu, Y He, Y Ikeda, Y Ikeda, Y Liu, Y Liu, Y Lu, Y Tozuka, Y Zhou, Y-Z Du, Z Lu, Z Wang   +153 more
core   +1 more source

Mesoporous Silica as a Carrier for Amorphous Solid Dispersion [PDF]

British Journal of Pharmaceutical research,2017, Vol 16, Issue 6, pages 1-19, 2017
In the past decade, the discovery of active pharmaceutical substances with high therapeutic value but poor aqueous solubility has increased, thus making it challenging to formulate these compounds as oral dosage forms. The bioavailability of these drugs can be increased by formulating these drugs as an amorphous drug delivery system.
arxiv   +1 more source

Activated carbon as a carrier for amorphous drug delivery: Effect of drug characteristics and carrier wettability [PDF]

European Journal of Pharmaceutics and Biopharmaceutics, 2017
Recent research on porous silica materials as drug carriers for amorphous and controlled drug delivery has shown promising results. However, due to contradictory literature reports on toxicity and high costs of production, it is important to explore alternative safe and inexpensive porous carriers.
Miriyala, Nikhila, Ouyang, Defang, Perrie, Yvonne, Lowry, Deborah, Kirby, Daniel J.   +4 more
openaire   +5 more sources

Use of artificial cells as drug carriers

Materials Chemistry Frontiers, 2021
Cells are the fundamental functional units of biological systems and mimicking their size, function and complexity is a primary goal in the development of new therapeutic strategies.
Stephanie K. Seidlits, Nureddin Ashammakhi, Nureddin Ashammakhi, Christopher H. Contag, Masamitsu Kanada, Jyrki Heinämäki, Sibel Emir Diltemiz, Maryam Tavafoghi, Natan Roberto de Barros, Natan Roberto de Barros   +9 more
openaire   +6 more sources

Synthesis and biodistribution of immunoconjugates of a human IgM and polymeric drug carriers [PDF]

, 1992
The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody directed against an intracellular tumour-associated antigen and either poly (alpha-L-glutamic acid) (PGA) or poly[N5-(2-hydroxyethyl)-L ...
Anderson, James M., Boon, P.J., Bos, E.S., Feijen, J., Grootoonk, J., Hoes, C.J.T., Kaspersen, F., Loeffen, P., Schlachter, I., Winters, M.   +9 more
core   +2 more sources

Two Strategies to Enhance Ungual Drug Permeation from UV-cured Films: Incomplete Polymerisation to Increase Drug Release and Incorporation of Chemical Enhancers [PDF]

, 2019
UV-curable gels, which polymerise into long-lasting films upon exposure to UVA, have been identified as potential topical drug carriers for the treatment of nail diseases.
Bardes, Josep, Hilton, Stephen, Kerai, Laxmi, Murdan, Sudaxshina   +3 more
core   +1 more source

Generalized Plasma Skimming Model for Cells and Drug Carriers in the Microvasculature [PDF]

, 2016
In microvascular transport, where both blood and drug carriers are involved, plasma skimming has a key role on changing hematocrit level and drug carrier concentration in capillary beds after continuous vessel bifurcation in the microvasculature. While there have been numerous studies on modeling the plasma skimming of blood, previous works lacked in ...
arxiv   +1 more source

Counterion-release entropy governs the inhibition of serum proteins by polyelectrolyte drugs [PDF]

Biomacromolecules, 2018, 19 (2), pp 409-416, 2017
Dendritic polyelectrolytes constitute high potential drugs and carrier systems for biomedical purposes, still their biomolecular interaction modes, in particular those determining the binding affinity to proteins, have not been rationalized. We study the interaction of the drug candidate dendritic polyglycerol sulfate (dPGS) with serum proteins using ...
arxiv   +1 more source