Results 211 to 220 of about 737,831 (320)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Estimating the treatment effects of multiple drug combinations on multiple outcomes in hypertension. [PDF]

Cell Rep Med
Liu R, Li L, Zhang P.
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

High-throughput approaches to uncover synergistic drug combinations in leukemia. [PDF]

SLAS Discov, 2023
Chory EJ, Wang M, Ceribelli M, Michalowska AM, Golas S, Beck E, Klumpp-Thomas C, Chen L, McKnight C, Itkin Z, Wilson KM, Holland D, Divakaran S, Bradner J, Khan J, Gryder BE, Thomas CJ, Stanton BZ.   +17 more
europepmc   +1 more source

Assessing synergy or antagonism for drug combinations

, 2004
Angus Bell, Stella G. Machado
openalex   +1 more source

Defining Fractional Inhibitory Concentration Index Cutoffs for Additive Interactions Based on Self-Drug Additive Combinations, Monte Carlo Simulation Analysis, and In Vitro - In Vivo Correlation Data for Antifungal Drug Combinations against Aspergillus fumigatus [PDF]

, 2009
Joseph Meletiadis, Spyros Pournaras, Emmanuel Roilides, Thomas J. Walsh   +3 more
openalex   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Corrigendum: Differential effects of clopidogrel and/or aspirin on the healing of tooth extraction wound bone tissue

Frontiers in Physiology
Jiaping Wang, Juan Lin, Xin Song, Mengting Wang, Yan Chen, Ning Luo, Xin Wu   +6 more
doaj   +1 more source

Cancer Cell's Achilles Heels: Considerations for Design of Anti-Cancer Drug Combinations. [PDF]

Int J Mol Sci
Gahramanov V, Vizeacoumar FS, Morales AM, Bonham K, Sakharkar MK, Kumar S, Vizeacoumar FJ, Freywald A, Sherman MY.   +8 more
europepmc   +1 more source

DeepTraSynergy: drug combinations using multimodal deep learning with transformers. [PDF]

Bioinformatics, 2023
Rafiei F, Zeraati H, Abbasi K, Ghasemi JB, Parsaeian M, Masoudi-Nejad A.   +5 more
europepmc   +1 more source