Results 41 to 50 of about 793,336 (333)

Combination of Dexmedetomidine with Bupivacaine versus Fentanyl with Bupivacaine Intrathecally for Prolongation of Postoperative Analgesia in Lower Limb Surgeries: A Randomised Clinical Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Intrathecal adjuvants can be added to extend the duration of analgesia. To achieve this, several adjuvants, such as the combination of dexmedetomidine with bupivacaine versus fentanyl with bupivacaine, have been used with local anaesthesia ...
Arjun Peddapally, Ezhilrajan Vaithiyalingam, Shanmugavalli Ettiyan, Haribabu Veeraraghavan   +3 more
doaj   +1 more source

Self-assembly of multi-component fluorescent molecular logic gates in micelles [PDF]

, 2016
A recent strategy for developing supramolecular logic gates in water is based on combinations of molecules via self-assembly with surfactants, which eliminates the need for time-consuming synthesis. The self-assembly of surfactants and lumophores and
Costa, Paola F. da, Magri, David C., Paterson, Kyle A.   +2 more
core   +1 more source

Drug Combinations: Mathematical Modeling and Networking Methods

Pharmaceutics, 2019
Treatments consisting of mixtures of pharmacological agents have been shown to have superior effects to treatments involving single compounds. Given the vast amount of possible combinations involving multiple drugs and the restrictions in time and ...
Vahideh Vakil, Wade Trappe
doaj   +1 more source

Clinical development of new drug-radiotherapy combinations. [PDF]

, 2016
In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most cost-effective cancer treatments.
Adams, RA, Ataman, O, Baird, RD, Billingham, L, Brown, SR, Buckland, S, Bulbeck, H, Chalmers, AJ, Clack, G, Clay, R, Cranston, AN, Damstrup, L, Ferraldeschi, R, Forster, MD, Golec, J, Greenhalgh, TA, Hagan, RM, Hall, E, Hanauske, AR, Harrington, KJ, Haswell, T, Hawkins, MA, Illidge, T, Jones, H, Kelly, S, Kennedy, AS, McDonald, F, Melcher, T, NCRI CTRad Academia-Pharma Joint Working Group, O'Connor, JP, Plummer, R, Pollard, JR, Saunders, MP, Sebag-Montefiore, D, Sharma, RA, Smitt, M, Staffurth, J, Stock, JK, Stratford, IJ, Wedge, SR   +39 more
core   +9 more sources

PINet 1.0: A pathway network-based evaluation of drug combinations for the management of specific diseases

Frontiers in Molecular Biosciences, 2022
Drug combinations can increase the therapeutic effect by reducing the level of toxicity and the occurrence of drug resistance. Therefore, several drug combinations are often used in the management of complex diseases.
Yongkai Hong, Dantian Chen, Yaqing Jin, Mian Zu, Yin Zhang   +4 more
doaj   +1 more source

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. [PDF]

, 2018
Dysregulation of the PI3K-AKT-mTOR signaling network is a prominent feature of breast cancers. However, clinical responses to drugs targeting this pathway have been modest, possibly because of dynamic changes in cellular signaling that drive resistance ...
A Bosch, A Katsha, A Subramanian, AA Dar, Andrei Goga, AS Nikonova, AV Statsuk, AY Choo, B MacLean, C Leroy, Cancer Genome Atlas Network., D Bankston, DA Fruman, F Janku, F Zheng, GR Anderson, H Daub, H Yang, Hayley J. Donnella, J Baselga, J Foucquier, J Hollander den, J Lehár, JA Diehl, James E. Korkola, James T. Webber, JE Ferrell Jr., JF Blake, John D. Gordan, JS Duncan, KE O’Reilly, Kevan M. Shokat, Khyati N. Shah, KJ Brewer Savannah, L Boussemart, L Lu, L Vadlakonda, LL Liu, M Bantscheff, M Barvian, M Choi, M Elkabets, M Laplante, M Piccart, M Tanaka, MJ West, MK Muellner, ML Sos, MM Martins, N Dey, N Ilic, N Volkmann, Nora Bayani, Olga Momcilovic, P Liu, PM Barr, PP Roux, QB She, R Sears, RB Corcoran, Rebecca S. Levin, RM Neve, Roman Camarda, SJ Klempner, SMA Lens, Sourav Bandyopadhyay, SR Vora, TJ Stuhlmiller, TK Nomanbhoy, Y Zwang   +69 more
core   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation [PDF]

, 2015
The actin and microtubule cytoskeletons are critically important for cancer cell proliferation, and drugs that target microtubules are widely-used cancer therapies. However, their utility is compromised by toxicities due to dose and exposure. To overcome
Baugh, Mark, Brookfield, Joanna, Charles, Mark, Crighton, Diane, Croft, Daniel R., Gabrielsen, Mads, Garnett, Mathew J., Hammonds, Tim, James, Daniel, Kalna, Gabriela, Kowalczyk, Dominika, Lourenco, Filipe, Mardilovich, Katerina, McDermott, Ultan, McGarry, Lynn, Munro, June, Olson, Michael F., Rath, Oliver, Shanks, Emma   +18 more
core   +2 more sources

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source