Results 41 to 50 of about 769,426 (246)

Combinations of drugs in the Treatment of Obesity [PDF]

Pharmaceuticals, 2010
Obesity is a chronic disease associated with excess morbidity and mortality. Clinical treatment, however, currently offers disappointing results, with very high rates of weight loss failure or weight regain cycles, and only two drugs (orlistat and sibutramine) approved for long-term use.
Maria Edna de Melo, Alfredo Halpern, Bruno Halpern, Marcio C. Mancini, Eduardo S. L. Oliveira, André M. Faria, Cintia Cercato   +6 more
openaire   +3 more sources

Systematic Prediction of Antifungal Drug Synergy by Chemogenomic Screening in Saccharomyces cerevisiae

Frontiers in Fungal Biology, 2021
Since the earliest days of using natural remedies, combining therapies for disease treatment has been standard practice. Combination treatments exhibit synergistic effects, broadly defined as a greater-than-additive effect of two or more therapeutic ...
Hamid Gaikani, Hamid Gaikani, Andrew M. Smith, Anna Y. Lee, Guri Giaever, Corey Nislow, Corey Nislow   +6 more
doaj   +1 more source

Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules [PDF]

Pharmaceuticals, 2018
Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently relies on a single drug, praziquantel, and despite its efficacy against the all schistosome species that parasitize humans, it displays some problematic drawbacks and alone is ineffective in counteracting adverse pathologies associated with infection.
Paul J. Brindley, Fátima Gärtner, Fátima Gärtner, Maria João Gouveia, Nuno Vale, José Manuel Correia da Costa, José Manuel Correia da Costa   +6 more
openaire   +4 more sources

Combination of Dexmedetomidine with Bupivacaine versus Fentanyl with Bupivacaine Intrathecally for Prolongation of Postoperative Analgesia in Lower Limb Surgeries: A Randomised Clinical Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Intrathecal adjuvants can be added to extend the duration of analgesia. To achieve this, several adjuvants, such as the combination of dexmedetomidine with bupivacaine versus fentanyl with bupivacaine, have been used with local anaesthesia ...
Arjun Peddapally, Ezhilrajan Vaithiyalingam, Shanmugavalli Ettiyan, Haribabu Veeraraghavan   +3 more
doaj   +1 more source

Drug Combinations: Mathematical Modeling and Networking Methods

Pharmaceutics, 2019
Treatments consisting of mixtures of pharmacological agents have been shown to have superior effects to treatments involving single compounds. Given the vast amount of possible combinations involving multiple drugs and the restrictions in time and ...
Vahideh Vakil, Wade Trappe
doaj   +1 more source

Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter [PDF]

, 1967
Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects.
Brunak, Søren, Halasz, Melinda, Huber, Kilian V.M., Kolch, Walter, Papamarkou, Theodore, Radic-Sarikas, Branka, Superti-Furga, Giulio, Tsafou, Kalliopi P., Winter, Georg E.   +8 more
core   +3 more sources

Newer drug combinations for malaria [PDF]

BMJ, 2004
May be impractical unless diagnostic accuracy can be improved Resistance of parasites to cheap, first line malaria drugs is a major obstacle to reducing the more than one million deaths due to malaria each year worldwide. Comparing the number of parasitologically confirmed cases of malaria with those that are presumptively diagnosed reveals ...
Guy Barnish, James Iboro, Imelda Bates
openaire   +3 more sources

Clinical development of new drug-radiotherapy combinations. [PDF]

, 2016
In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most cost-effective cancer treatments.
Adams, RA, Ataman, O, Baird, RD, Billingham, L, Brown, SR, Buckland, S, Bulbeck, H, Chalmers, AJ, Clack, G, Clay, R, Cranston, AN, Damstrup, L, Ferraldeschi, R, Forster, MD, Golec, J, Greenhalgh, TA, Hagan, RM, Hall, E, Hanauske, AR, Harrington, KJ, Haswell, T, Hawkins, MA, Illidge, T, Jones, H, Kelly, S, Kennedy, AS, McDonald, F, Melcher, T, NCRI CTRad Academia-Pharma Joint Working Group, O'Connor, JP, Plummer, R, Pollard, JR, Saunders, MP, Sebag-Montefiore, D, Sharma, RA, Smitt, M, Staffurth, J, Stock, JK, Stratford, IJ, Wedge, SR   +39 more
core   +9 more sources

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. [PDF]

, 2018
Dysregulation of the PI3K-AKT-mTOR signaling network is a prominent feature of breast cancers. However, clinical responses to drugs targeting this pathway have been modest, possibly because of dynamic changes in cellular signaling that drive resistance ...
A Bosch, A Katsha, A Subramanian, AA Dar, Andrei Goga, AS Nikonova, AV Statsuk, AY Choo, B MacLean, C Leroy, Cancer Genome Atlas Network., D Bankston, DA Fruman, F Janku, F Zheng, GR Anderson, H Daub, H Yang, Hayley J. Donnella, J Baselga, J Foucquier, J Hollander den, J Lehár, JA Diehl, James E. Korkola, James T. Webber, JE Ferrell Jr., JF Blake, John D. Gordan, JS Duncan, KE O’Reilly, Kevan M. Shokat, Khyati N. Shah, KJ Brewer Savannah, L Boussemart, L Lu, L Vadlakonda, LL Liu, M Bantscheff, M Barvian, M Choi, M Elkabets, M Laplante, M Piccart, M Tanaka, MJ West, MK Muellner, ML Sos, MM Martins, N Dey, N Ilic, N Volkmann, Nora Bayani, Olga Momcilovic, P Liu, PM Barr, PP Roux, QB She, R Sears, RB Corcoran, Rebecca S. Levin, RM Neve, Roman Camarda, SJ Klempner, SMA Lens, Sourav Bandyopadhyay, SR Vora, TJ Stuhlmiller, TK Nomanbhoy, Y Zwang   +69 more
core   +1 more source

Immune checkpoint inhibitors in renal cell carcinoma [PDF]

, 2017
The immune system has long been known to play a critical role in the body's defence against cancer, and there have been multiple attempts to harness it for therapeutic gain.
Jones, Robert J., Ross, Kirsty
core   +1 more source