Results 51 to 60 of about 769,426 (246)
Investigating therapeutic efficacy of dacarbazine and temozolomide, alone and in combination with BRAF(V600E) siRNA in A375 human melanoma cell line [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Melanoma is one of the most aggressive and deadly skin cancers. Despite advances, effective melanoma treatment is challenging, often requiring a shift from individual therapies to combination approaches.
Fatemeh Tabandeh +3 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Drug combinations can increase the therapeutic effect by reducing the level of toxicity and the occurrence of drug resistance. Therefore, several drug combinations are often used in the management of complex diseases.
Yongkai Hong +4 more
doaj +1 more source
Self-assembly of multi-component fluorescent molecular logic gates in micelles [PDF]
, 2016 A recent strategy for developing supramolecular logic gates in water is based on combinations of molecules via self-assembly with surfactants, which eliminates the need for time-consuming synthesis. The self-assembly of surfactants and lumophores and
Costa, Paola F. da +2 more
core +1 more source
Microorganisms, 2022 Background: The turnaround times for phenotypic tests used to monitor the bacterial load of Mycobacterium tuberculosis, in both clinical and preclinical studies, are delayed by the organism’s slow growth in culture media.
Dimitrios Evangelopoulos +7 more
doaj +1 more source
Systematic Identification of Synergistic Drug Pairs Targeting HIV [PDF]
, 2013 The systematic identification of effective drug combinations has been hindered by the unavailability of methods that can explore the large combinatorial search space of drug interactions.
Elledge, Stephen J. +9 more
core +1 more source
Engineering drug combinations [PDF]
Nature Chemical Biology, 2010 The level of an individual protein in cells treated with combinations of drugs is best explained by simple linear superposition of the protein levels in response to single drugs. This finding may facilitate rational design of higher order drug combinations.
Scott J. Dixon, Brent R. Stockwell
openaire +2 more sources
LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation [PDF]
, 2015 The actin and microtubule cytoskeletons are critically important for cancer cell proliferation, and drugs that target microtubules are widely-used cancer therapies. However, their utility is compromised by toxicities due to dose and exposure. To overcome
Baugh, Mark +18 more
core +2 more sources
AntibioticsLeishmaniasis is a tropical infectious disease caused by Leishmania parasites. The disease can be spread by the bite of an infected sand fly. Currently, five chemotherapeutic drugs are available in leishmaniasis treatment.
Nuchpicha Intakhan +4 more
doaj +1 more source
One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening [PDF]
, 2019 Large-scale screening of sequential drug combinations, wherein the dynamic rewiring of intracellular pathways leads to promising therapeutic effects and improvements in quality of life, is essential for personalized medicine to ensure realistic cost and ...
Bae, Hyung Jong +10 more
core +1 more source
Radiotherapy-induced ferroptosis for cancer treatment
Frontiers in Molecular Biosciences, 2023 Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very relevant for cancer therapy.
Giovanni L. Beretta, Nadia Zaffaroni
doaj +1 more source