Results 91 to 100 of about 73,853 (306)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Recommendations on training objectives and staff qualification for the manual preparation of capsules in pharmacy

Pharmaceutical Technology in Hospital Pharmacy
Training and certification of personnel in capsule preparation are essential procedures, overseen by the pharmacist who delegates these tasks. These procedures aim not only to ensure the efficacy and safety of operations but also to establish a clear ...
Marçon Frédéric, Lagarce Frédéric, Roland Isabelle, Brossard Denis, Merienne Camille, Chennell Philip, d’Huart Elise, Briot Thomas, Carrez Laurent, Podilsky Gregory, Rohrbach Pascal, Lannoy Damien, Storme Thomas, Guerrault-Moro Marie Noelle, Soulairol Ian, Crauste-Manciet Sylvie   +15 more
doaj   +1 more source

Formulation and Stability of a 1% Clarithromycin-Based Topical Skin Cream: A New Option to Treat Buruli Ulcers?

Pharmaceuticals
There are more than 170 known species of non-tuberculous mycobacteria, and some are responsible for serious diseases in people infected with them. One of these is Buruli ulcers, a neglected tropical disease endemic in more than 33 countries and caused by
Maria Sebti, Arnaud Schweitzer-Chaput, Salvatore Cisternino, Mélanie Hinterlang, Dimitri Ancedy, Sandrine Lam, Sylvain Auvity, Camille Cotteret, Olivier Lortholary, Joël Schlatter   +9 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Paediatric orodispersible lozenges produced by moulding process: quality and stability control

Pharmaceutical Technology in Hospital Pharmacy
Active pharmaceutical ingredients for paediatric patients are formulated at hospital pharmacy services and compounding pharmacies when they are not commercially available.
Magariños-Triviño María, Monzón-Rodríguez Cecilia, Caiazzo-Lima José Andrés, Santoveña-Estévez Ana, Fariña José B.   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Plant polyphenolic compounds as potential antimicrobial drugs [PDF]

Journal of Medical Microbiology, 2011
Recently there has been much discussion about the possibility that plant derived phytochemical compounds may exert a role as potential anti-microbial substances; however, many issues have to be faced. Results appear quite encouraging but, nevertheless, most of them resulted from in vitro research or using animal models, whilst clinical outcomes ...
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A comparative review of Haute Autorité de Santé and National Institute for Health and Care Excellence health technology assessments of Ikervis® to treat severe keratitis in adult patients with dry eye disease which has not improved despite treatment with tear substitutes

Journal of Market Access & Health Policy, 2017
Background: In 2015, Ikervis® became the only EMA-approved cyclosporine A (CsA) eye-drop for the treatment of severe keratitis in adult patients with dry eye disease, which has not improved despite treatment with tear substitutes.
Yasmina Iffet Eroglu
doaj   +1 more source

Libertarianism: an Extremely Short Introduction [PDF]

, 2016
(Revised 31-10-17) This is only one view on the topic; other views may be rather different. It starts at the more philosophical end and then becomes more empirical, and possibly easier to understand, as it ...
Lester, J. C.
core