Results 131 to 140 of about 79,448 (358)
The compounding of short fibre reinforced thermoplastic composites [PDF]
, 1988 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.It is generally accepted that the mechanical properties of short fibre reinforced thermoplastics do not correspond with the high mechanical properties of ...
Shipton, Paul David
core
Early Drug Development and Evaluation of Putative Antitubercular Compounds in the -Omics Era [PDF]
, 2021 Alina Minias +7 more
openalex +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Development of a Hydrocortisone Orodispersible Thin Film Containing Its Succinate Prodrug
PharmaceuticalsOrodispersible thin film (ODF) is an innovative dosage form that allows for adjustable dosing and improved patient compliance. It is administered by mouth, where it dissolves, making it suitable for children.
Clément Boisseillier +9 more
doaj +1 more source
Problems Prisoners Face in the Reentry Industry [PDF]
, 2015 Prison sentences vary depending on the crime committed. When sentences come to an end, prisoners return to society. Society does not just accept these prisoners back into everyday life with open arms.
Plant, Jessica
core +2 more sources
, 2008 Collaborative Drug Discovery (CDD) and Asinex have released an OA edition of the Asinex drug compound libraries through the CDD online drug discovery database. For details, see today's announcement.
openaire +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Long-Term Stability of Glycopyrrolate Oral Solution Galenic Compound at Different Storage Conditions
PharmaceuticsGlycopyrrolate is a competitive muscarinic receptor antagonist used in the treatment of sialorrhea, especially in pediatrics. Degradation research was conducted to better understand the stability of the active pharmaceutical ingredient (API).
Barbara Bellich +11 more
doaj +1 more source