Results 241 to 250 of about 79,448 (358)

A new model to correlate solubility of drug compounds in supercritical carbon dioxide

Raghavan Amrithaa, Ratna Surya Alwi, M. Geetha Devi, Chandrasekhar Garlapati   +3 more
openalex   +1 more source

Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors

, 2014
Brian P. Mahon, Alex M. Hendon, Jenna M. Driscoll, Gregory M. Rankin, Sally‐Ann Poulsen, Claudiu T. Supuran, Robert McKenna   +6 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Innovation in Onychomycosis Treatment Through Creative Compounding. [PDF]

Cureus
Hoffman K, Gorski M, Frey CP.
europepmc   +1 more source

In Silico Identification of Escherichia coli Curli Protein Phytochemical Inhibitors as Potential Antibiotic Drug Compounds for Urinary Tract Infection via Molecular Docking

Den Marc Panes Exala, Earl Adriane Cano, Angela Nole Shayenne Tano Coderos, Danielle Cruz, Samson Pan Decasa, Juliana Carlidy Llena Elauria, Jalen Rose Panaligan Esguerra, A. Ferrer   +7 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Stability study of topotecan in ophthalmic prefilled syringes for intravitreal delivery. [PDF]

Eur J Hosp Pharm
Bello W, Hosotte C, Stampfli C, Pierrot A, Munier FL, Berger-Gryllaki M, Pezzatti J, Carrez L, Sadeghipour F.   +8 more
europepmc   +1 more source

Law & Healthcare Newsletter, v. 22, no. 1, Fall 2014 [PDF]

, 2014

core   +1 more source

Screening of Potential Anticancer Compounds from Marketed Drugs: Aripiprazole, Haloperidol, Miconazole, and Terfenadine Inhibit Cytochrome P450 2J2

, 2011
Kwang‐Hyeon Liu
openalex   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source