Results 111 to 120 of about 4,579,977 (389)
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Проблемы особо опасных инфекций, 2016 Nowadays, problem of tableted drug form contamination with extraneous micro-flora is in the spotlight of scientists, as the specific share of these medical preparations in the world market amounts to more than 60 % and has a tendency to increase.
A. S. Tumanov +11 more
doaj +1 more source
Impurities in Drug Vials Intended for Intravitreal Medication
Case Reports in Ophthalmological Medicine, 2020 Sterility is an important prerequisite for minimizing the risk of severe vision loss due to endophthalmitis after intravitreal injections. We describe three cases series of incidents where an unclear contamination of the drug solution or syringe caused ...
Lisa Pohl +3 more
doaj +1 more source
Fixing Food Safety: Protecting America's Food Supply From Farm-to-Fork [PDF]
, 2008 Provides an overview of the major concerns regarding U.S. food safety, including an ineffective regulatory system, and of food-borne disease threats.
Jeffrey Levi +2 more
core
Contamination of the Norepinephrine Pro‐Drug Droxidopa by Dihydroxyphenylacetaldehyde
The FASEB Journal, 2010 BackgroundDroxidopa (3,4‐threo‐L‐dihydroxyphenylserine, L‐DOPS) is a norepinephrine (NE) pro‐drug under development to treat orthostatic hypotension. 3,4‐Dihydroxyphenylacetaldehyde (DOPAL) is a toxic catecholaldehyde.MethodsThirteen subjects took 400 mg Droxidopa orally, with blood sampled at baseline and 1, 2, 3, 6, 24, and 48 hours after drug ...
David S. Goldstein, Courtney Holmes
openaire +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Dried blood spots in toxicology : from the cradle to the grave? [PDF]
, 2012 About a century after its first described application by Ivar Bang, the potential of sampling via dried blood spots (DBS) as an alternative for classical venous blood sampling is increasingly recognized.
De Kesel, Pieter +3 more
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Side-by-Side Comparison of Methods for Environmental Monitoring for Hazardous Drug Contamination. [PDF]
Can J Hosp Pharm, 2023 Hon CY.
europepmc +1 more source
, 2019 A safe food supply is essential for a healthy society. Our food system is replete with different types of risk, yet food safety is often narrowly understood as encompassing only foodborne illness and other risks related directly to food ingestion.
Broad Leib, Emily M., Pollans, Margot J.
core +1 more source