Results 11 to 20 of about 1,809,547 (313)

Microneedles: A smart approach and increasing potential for transdermal drug delivery system.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019
The most widely used methods for transdermal administration of the drugs are hypodermic needles, topical creams, and transdermal patches. The effect of most of the therapeutic agents is limited due to the stratum corneum layer of the skin, which serves ...
Tejashree Waghule, Gautam Singhvi, S. Dubey, M. M. Pandey, G. Gupta, Mahaveer Singh, K. Dua   +6 more
semanticscholar   +1 more source

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Nanomaterials, 2020
Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell.
Siyuan Deng, M. Gigliobianco, R. Censi, P. Di Martino   +3 more
semanticscholar   +1 more source

Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: A review

, 2020
This review discussed about the green biosynthesis of magnetite nanoparticles (Fe3O4-NPs) and the biomedical applications, which mainly focus on the targeted anticancer drug delivery.
Yen Pin Yew, K. Shameli, M. Miyake, N. A. Khairudin, S. E. Mohamad, T. Naiki, Kar Xin Lee   +6 more
semanticscholar   +1 more source

Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting

Drug Delivery, 2018
Glioblastoma is the most common malignant brain tumor. Efficient delivery of drugs targeting glioblastomas remains a challenge. Ephrin type-A receptor 3 (EPHA3) tyrosine kinase antibody-modified polylactide-co-glycolide (PLGA) nanoparticles (NPs) were ...
Liuxiang Chu, Aiping Wang, Ling Ni, Xiuju Yan, Yina Song, Mingyu Zhao, Kaoxiang Sun, Hongjie Mu, Sha Liu, Zimei Wu, Chunyan Zhang   +10 more
doaj   +1 more source

A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy

Nano-Micro Letters, 2020
The current approaches of cancer immunotherapy were summarized. The prospects in combination of chemotherapy and immunotherapy were discussed. The recent progress of nano-based drug delivery systems applied for cancer chemoimmunotherapy was further ...
W. Mu, Qihui Chu, Yongjun Liu, Na Zhang
semanticscholar   +1 more source

Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease

Research, 2023
Inflammatory responses, manifested in excessive oxidative stress and microglia overactivation, together with metal ion-triggered amyloid-beta (Aβ) deposition, are critical hallmarks of Alzheimer’s disease (AD).
Qianqian Huang, Chaoqing Jiang, Xue Xia, Yufan Wang, Chenxing Yan, Xiaorong Wang, Ting Lei, Xiaotong Yang, Wenqin Yang, Guo Cheng, Huile Gao   +10 more
doaj   +1 more source

Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery

Nanoscale Research Letters, 2019
In this paper, a type of phycocyanin (PC)-functionalized and curcumin (CUR)-loaded biotin-chitosan oligosaccharide-dithiodipropionic acid-curcumin (BCSC) nanoparticles, called CUR-BCSC@PCs, were designed to enhance the biocompatibility of CUR.
Ziting Cheng, Wei Zhang, Xiaoya Hou, Bingjie Wang, Yanping Zhu, Peng Zhang, Feng Zhao, Daquan Chen   +7 more
doaj   +1 more source

pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy

Nature Communications, 2023
Tumour-associated macrophages (TAMs), as one of the most abundant tumour-infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune suppression.
Mingmei Tang, Binlong Chen, Heming Xia, Meijie Pan, Ruiyang Zhao, Jiayi Zhou, Qingqing Yin, Fangjie Wan, Yue Yan, Chuanxun Fu, Lijun Zhong, Qiang Zhang, Yiguang Wang   +12 more
doaj   +1 more source

Pharmacological Characterization of Toludesvenlafaxine as a Triple Reuptake Inhibitor

Frontiers in Pharmacology, 2021
Toludesvenlafaxine hydrochloride dihydrate is a novel chemical entity and a potential triple monoamine reuptake inhibitor. This study characterized the in vitro triple reuptake inhibition activity, antidepressant-like activity in animals, and ...
Haibo Zhu, Wenyan Wang, Chunjie Sha, Wei Guo, Chunmei Li, Fengjuan Zhao, Hongbo Wang, Wanglin Jiang, Jingwei Tian, Jingwei Tian   +9 more
doaj   +1 more source

The blood–brain barrier: Structure, regulation and drug delivery

Signal Transduction and Targeted Therapy, 2023
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and ...
Di Wu, Qi Chen, Xiaojie Chen, Feng Han, Zhong Chen, Yi Wang   +5 more
semanticscholar   +1 more source