Results 21 to 30 of about 1,809,547 (313)

Novel Dual Mitochondrial and CD44 Receptor Targeting Nanoparticles for Redox Stimuli-Triggered Release

Nanoscale Research Letters, 2018
In this work, novel mitochondrial and CD44 receptor dual-targeting redox-sensitive multifunctional nanoparticles (micelles) based on oligomeric hyaluronic acid (oHA) were proposed.
Kaili Wang, Mengjiao Qi, Chunjing Guo, Yueming Yu, Bingjie Wang, Lei Fang, Mengna Liu, Zhen Wang, Xinxin Fan, Daquan Chen   +9 more
doaj   +1 more source

Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting

Acta Pharmaceutica Sinica B, 2019
Multidrug resistance (MDR) has been considered as a huge challenge to the effective chemotherapy. Therefore, it is necessary to develop new strategies to effectively overcome MDR. Here, based on the previous research of N-(2-hydroxypropyl)methacrylamide (
Minglu Zhou, Lijia Li, Lian Li, Xi Lin, Fengling Wang, Qiuyi Li, Yuan Huang   +6 more
doaj   +1 more source

TARGETED DRUG DELIVERY SYSTEM: A REVIEW

International Research Journal of Modernization in Engineering Technology and Science
Targeted drug delivery is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others.
Gupta Manish, Sharma Vimukta
semanticscholar   +1 more source

Intracochlear drug delivery systems [PDF]

Expert Opinion on Drug Delivery, 2011
Advances in molecular biology and in the basic understanding of the mechanisms associated with sensorineural hearing loss and other diseases of the inner ear are paving the way towards new approaches for treatments for millions of patients. However, the cochlea is a particularly challenging target for drug therapy, and new technologies will be required
openaire   +2 more sources

Nanotechnology-based Drug Delivery Systems [PDF]

Journal of Occupational Medicine and Toxicology, 2007
Abstract Nanoparticles hold tremendous potential as an effective drug delivery system. In this review we discussed recent developments in nanotechnology for drug delivery. To overcome the problems of gene and drug delivery, nanotechnology has gained interest in recent years.
Singh Baljit, Fenniri Hicham, Suri Sarabjeet   +2 more
openaire   +3 more sources

A model‐based meta‐analysis of immune‐related adverse events during immune checkpoint inhibitors treatment for NSCLC

CPT: Pharmacometrics & Systems Pharmacology, 2022
Immune checkpoint inhibitors (ICIs) have become a vital part of the therapeutic landscape for non‐small cell lung cancer (NSCLC) in recent years benefiting from their remarkable efficacy.
Renwei Zhang, Daming Kong, Rong Chen, Yuchen Guo, Weizhe Jian, Mengyi Han, Tianyan Zhou   +6 more
doaj   +1 more source

Techniques for Formulation of Nanoemulsion Drug Delivery System: A Review

Preventive Nutrition and Food Science, 2019
Nanoemulsion drug delivery systems are advanced modes for delivering and improving the bioavailability of hydrophobic drugs and the drug which have high first pass metabolism.
Manish Kumar, R. Bishnoi, A. Shukla, C. Jain   +3 more
semanticscholar   +1 more source

Nafamostat Mesylate Regulates Glycosylation to Alleviate Aristolochic Acid Induced Kidney Injury

Toxins
Acute kidney injury (AKI) is a condition with a poor prognosis, exacerbated by the lack of effective therapeutic options and inadequately understood underlying mechanisms.
Pei Xie, Huijun Liu, Xingli Huo, Junlong Chen, Yu Li, Yu Huang, Zongning Yin   +6 more
doaj   +1 more source

Synthesis and In Vivo Antiarrhythmic Activity Evaluation of Novel Scutellarein Analogues as Voltage-Gated Nav1.5 and Cav1.2 Channels Blockers

Molecules, 2023
Malignant cardiac arrhythmias with high morbidity and mortality have posed a significant threat to our human health. Scutellarein, a metabolite of Scutellarin which is isolated from Scutellaria altissima L., presents excellent therapeutic effects on ...
Wei Yang, Wenping Wang, Song Cai, Peng Li, Die Zhang, Jinhua Ning, Jin Ke, Anguo Hou, Linyun Chen, Yunshu Ma, Wenbin Jin   +10 more
doaj   +1 more source

Statistically designed enzymatic hydrolysis of an icariin/β-cyclodextrin inclusion complex optimized for production of icaritin

Acta Pharmaceutica Sinica B, 2012
This study focuses on the preparation and enzymic hydrolysis of an icariin/β-cyclodextrin inclusion complex to efficiently generate icaritin. The physical characteristics of the inclusion complex were evaluated by differential scanning calorimetry (DSC).
Xin Jin, Zhenhai Zhang, E. Sun, Songlin Li, Xiaobin Jia   +4 more
doaj   +1 more source