Results 111 to 120 of about 1,036,500 (313)

Poly(lactic-co-glycolic) acid drug delivery systems through transdermal pathway : an overview [PDF]

, 2017
In past few decades, scientists have made tremendous advancement in the field of drug delivery systems (DDS), through transdermal pathway, as the skin represents a ready and large surface area for delivering drugs.
AE Porter, AK Kohli, B Hafner, CJ Ke, DP Bottaro, E Garcia-Garcia, F Ajalloueian, F Stracke, G Jin, J Luengo, J Panyam, JH Park, JM Antonini, KF Soto, L Jacob, L Xiao, N Li, P Kocbek, PS Korrapati, R Alvarez-Romn, R Dinarvand, R Langer, R Langer, R Qi, R Sridhar, RF Donnelly, S Acharya, S Takenaka, T Xia, U Bilati, V Petkov, XS Wu, Y Zhang, YK Demir, YK Luu, Z Zhang, ZX Meng, ZX Meng   +37 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Intrathecal drug delivery systems for the management of chronic non-cancer pain : a systematic review of economic evaluations [PDF]

Background: Intrathecal drug delivery (ITDD) systems are one of a limited number of management options for chronic non-cancer pain, cancer pain and spasticity.
Andronis, L. (Lazaros), Duarte, Rui, Eldabe, Sam, Lambe, Tosin, Raphael, Jon   +4 more
core   +1 more source

Marine origin polysaccharides in drug delivery systems [PDF]

, 2016
Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development ...
Bansal, Contreras-Ruiz, Costa, Jimeno, João Mano, Kim, Krebs, Matias Cardoso, Mohammad, Panlasigui, Roy, Rui Costa, Sezer, Silva, Uchimura, Valoti   +15 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Nanotechnology in drug delivery: the need for more cell culture based studies in screening [PDF]

, 2014
Advances in biomedical science are leading to upsurge synthesis of nanodelivery systems for drug delivery. The systems were characterized by controlled, targeted and sustained drug delivery ability.
Aminu Kura, Mohd Hussein, Palanisamy Arulselvan, Sharida Fakurazi   +3 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

A Universal Strategy of Anti‐Tumor mRNA Vaccine by Harnessing “Off‐the‐Shelf” Immunity

Advanced Science
Personalized neoantigen cancer mRNA vaccines are promising candidates for precision medicine. However, the difficulty of identifying neoantigens heavily hinders their broad applicability.
Jiayan Fu, Shuangqi Wu, Nengcheng Bao, Lili Wu, Huiru Qu, Zhechao Wang, Haiyang Dong, Jian Wu, Yongfeng Jin   +8 more
doaj   +1 more source

Cascade-targeted delivery platform enhances antigen cross-presentation and STING activation for durable cellular immunity

Bioactive Materials
Achieving robust and durable cellular immunity remains a key challenge in the development of subunit vaccines, primarily due to inefficient antigen cross-presentation and inadequate immune activation.
Yuan Xue, Shuting Bai, Yating Wang, Jiaxing Feng, Kun Xiong, Xue Tang, Chunting He, Yanhua Xu, Hongling Yu, Tianyi Luo, Qing Lin, Xun Sun, Ling Zhang, Zhirong Zhang, Tao Gong   +14 more
doaj   +1 more source

Rate-controlled rectal drug delivery in man with a hydrogel preparation [PDF]

, 1986
Cylindrical hydrogels of hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) as crosslinking agent were prepared by radical polymerization at 70°C.
Boer, A.G. de, Breimer, D.D., Feijen, J., Leede, L.G.J. de, Pörtzgen, E.   +4 more
core   +3 more sources