Results 91 to 100 of about 779,180 (303)

Modeling alcohol use disorder severity: An integrative structural equation modeling approach [PDF]

, 2013
Background: Alcohol dependence is a complex psychological disorder whose phenomenology changes as the disorder progresses. Neuroscience has provided a variety of theories and evidence for the development, maintenance, and severity of addiction; however ...
Bacio, GA, Courtney, KE, Moallem, NR, Ray, LA   +3 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Conditioned Place Preference Induced by Licit Drugs: Establishment, Extinction, and Reinstatement

The Scientific World Journal, 2008
The conditioned place preference (CPP) model has been widely used to evaluate the rewarding effects of abused drugs, and recently, the extinction and reinstatement phases of this paradigm have been used to assess relapse to drug seeking.
Yu Liu, Bernard Le Foll, Yanli Liu, Xi Wang, Lin Lu   +4 more
doaj   +1 more source

Neuroleptic Malignant Syndrome Associated with Lithium Toxicity

Oman Medical Journal, 2016
Neuroleptic Malignant Syndrome (NMS) is an idiosyncratic and potentially life-threatening reaction to neuroleptic drugs. Lithium is a first-line mood stabilizer used in the treatment and prophylaxis of bipolar disorder.
Vaibhav Patil, Rishab Gupta, Rohit Verma, Yatan Pal Singh Balhara   +3 more
doaj   +1 more source

An inevitable wave of prescription drug monitoring programs in the context of prescription opioids: pros, cons and tensions [PDF]

, 2014
BACKGROUND: In an effort to control non-medical use and/or medical abuse of prescription drugs, particularly prescription opioids, electronic prescription drug monitoring programs (PDMP) have been introduced in North-American countries, Australia and ...
Islam, M. Mofizul, McRae, Ian S.
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Comparing Marital Adjustment in Couples Having Alcohol- or Opioid-dependent Husbands

Indian Journal of Psychological Medicine
Background: Substance use disorder is a complex bio-psycho-social phenomenon affecting the intimate relationship of substance users with their wives. Marital adjustment may be affected due to the ongoing substance use involving the family unit.
Sayani Bisoi, Gauri Shanker Kaloiya, Anju Dhawan, Siddharth Sarkar   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cell-type specific epigenetic and transcriptional mechanisms in substance use disorder

Frontiers in Cellular Neuroscience
Substance use disorder (SUD) is a chronic and relapse-prone neuropsychiatric disease characterized by impaired brain circuitry within multiple cell types and neural circuits.
Bin Wang, Bin Wang, Jiale Wang, Jiale Wang, Nicholas J. Beacher, Da-Ting Lin, Da-Ting Lin, Yan Zhang   +7 more
doaj   +1 more source

A Review of Risk Factors for Methamphetamine-Related Psychiatric Symptoms

Frontiers in Psychiatry, 2018
The illegal use of methamphetamine (MA) is a growing public health concern globally and results in a series of negative effects. The prominent detrimental effect of MA use is MA-related psychiatric symptoms (MAP) and is observed at a much higher ...
Xiangwen Chang, Xiangwen Chang, Yan Sun, Yang Zhang, Yang Zhang, Jiana Muhai, Jiana Muhai, Lin Lu, Lin Lu, Lin Lu, Jie Shi, Jie Shi   +11 more
doaj   +1 more source