Results 111 to 120 of about 779,180 (303)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Common hyper-entropy patterns identified in nicotine smoking, marijuana use, and alcohol use based on uni-drug dependence cohorts. [PDF]

Med Biol Eng Comput, 2023
Jiang W, Cai L, Wang Z.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Systematic Review and Meta-Analysis of Attention, Memory, Learning, and Fluency Deficits Associated with Gambling Behavior

Neuropsychiatric Investigation
Objective: The study aimed to systematically review and analyze the association of gambling behavior with deficits in attention, memory, learning, verbal fluency, and figural fluency.
Yashita Ahluwalia, Parvender Singh Negi, Swarndeep Singh, Siddharth Sarkar, Yatan Pal Singh Balhara   +4 more
doaj   +1 more source

Effectiveness of opioid maintenance programs for treating drug dependence in prisons. [PDF]

Rev Esp Sanid Penit, 2023
Roselló-Jordá S, Espinós-Navarro C, Molés-Julio MP.   +2 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Case report on intervention of sedative drug dependence with "simple and quick reconstruction method" in psychological crisis assistance. [PDF]

Medicine (Baltimore), 2023
Liang YQ, Yu BD.
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The impact of REM sleep loss on human brain connectivity

Translational Psychiatry
Brain function is vulnerable to the consequences of inadequate sleep, an adverse trend that is increasingly prevalent. The REM sleep phase has been implicated in coordinating various brain structures and is hypothesized to have potential links to brain ...
Tianqi Di, Libo Zhang, Shiqiu Meng, Wangyue Liu, Yang Guo, Enyu Zheng, Chao Xie, Shitong Xiang, Tianye Jia, Lin Lu, Yan Sun, Jie Shi   +11 more
doaj   +1 more source

Similarities and Differences in Alcohol & Other Drug Dependence Among Hispanic/Latino Subgroups: A Disaggregation Approach. [PDF]

Drug Alcohol Depend Rep, 2022
Correa-Fernández V, Barazi AM, Chandra M, Anthony JC.   +3 more
europepmc   +1 more source