Results 71 to 80 of about 779,180 (303)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Relationship between thyroid-stimulating hormone and blood lipids in patients with first-episode depression

BMC Psychiatry
Background Previous studies demonstrated thyroid stimulating hormone (TSH) plays an important role in regulating lipid metabolism, but the relationship between the two is controversial.
Chun-Qing Cui, Zhe Li, Zi-Rong Hou, Yu-Mei Zhang, Xue-Zhu Feng, Xuan Tan, Yu-Yu Zhao, Su-Xia Li, Dong-Hua Tian, Xiang-Yang Zhang   +9 more
doaj   +1 more source

Vaccines to Treat Substance Use Disorders: Current Status and Future Directions

Pharmaceutics
Addiction, particularly in relation to psychostimulants and opioids, persists as a global health crisis with profound social and economic ramifications.
Tangsheng Lu, Xue Li, Wei Zheng, Chenyan Kuang, Bingyi Wu, Xiaoxing Liu, Yanxue Xue, Jie Shi, Lin Lu, Ying Han   +9 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Reasons for Individuals not Enrolling for Yoga trial in Addiction

European Psychiatry
Introduction Yoga has been demonstrated to have a range of beneficial effects on individuals with substance use disorders, including opioid use disorders.
S. Sarkar, A. Dhawan, R. Quraishi, P. S. Negi, A. Kumar   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Psychosocial characteristics of the general population who habitually use hypnotics: Results from a national survey on drug use among the Japanese

PCN Reports
Aim The aim of this study was to examine the characteristics of habitual hypnotic users in Japan. Methods This nationwide, cross‐sectional survey used self‐administered questionnaires.
Satomi Mizuno, Takuya Shimane, Satoshi Inoura, Toshihiko Matsumoto   +3 more
doaj   +1 more source

The relationship between anxiety and parent-child attachment and psychological resilience among Chinese college students: take 100 thousand college students as sample

Frontiers in Psychiatry
BackgroundPrevious studies on the relationship between good parent-child attachment, psychological resilience with mental health, have limitations such as small sample sizes and specific regions or universities, which lack universality.
Zhe Li, Yu-Yu Zhao, Yu-Yu Zhao, Xin Li, Xin Li, Ke Liu, Ke Liu, Dong-Hua Tian, Su-Xia Li, Xiang-Yang Zhang   +9 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source