Results 81 to 90 of about 779,180 (303)

BOOK REVIEW OF GAYLE FORMAN’S I WAS HERE [PDF]

open access: yes, 2016
It is often done as a result of, for examples, despair, depression, mental disorders, bipolar disorder, alcohol dependence or drug abuse. The factors that also causes suicide include financial difficulties or problems in interpersonal relationship ...
Roefmelinda, Aldeana
core  

Public spending for illegal drug and alcohol treatment in hospitals: an EU cross-country comparison [PDF]

open access: yes, 2014
Background: In view of the current economic crisis and the resulting austerity measures being implemented by governments across Europe, public expenditure for substance abuse treatment has increasingly become a subject of discussion.
Christiaens, Johan   +2 more
core   +3 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Cognition of Palliative Care and Experience of Palliative Sedation in Chinese Anesthesiologists: A National Cross-sectional Survey

open access: yesXiehe Yixue Zazhi
Objective  This study aimed to investigate Chinese anesthesiologists' comprehension of palliative care and their experiences with palliative sedation for patients in the end-stage of life.
YU Jiawen   +8 more
doaj   +1 more source

Global Overview of Drug Demand and Supply: Latest Trends, Cross-cutting Issues [PDF]

open access: yes, 2017
An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...

core  

Evaluation of the Debye temperature for iron cores in human liver ferritin and its pharmaceutical analogue Ferrum Lek using Mossbauer spectroscopy [PDF]

open access: yes, 2014
An iron polymaltose complex Ferrum Lek used as antianemic drug and considered as a ferritin analogue and human liver ferritin were investigated in the temperature range from 295K to 90K by means of 57Fe Mossbauer spectroscopy with a high velocity ...
Alenkina, I. V.   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The role of the control of “life’s essential 8” for prevention on heart failure and all-cause mortality in patients with hypertension: the Kailuan cohort study

open access: yesBMC Public Health
Background Hypertension can lead to an increased risk of heart failure and death. The life’s essential 8 (LE8) is an eight-factor measure of cardiovascular health recently released by the American Heart Association for use in measuring cardiovascular ...
Jing Wang   +10 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Effects of cue-synchronized parietal cathodal tDCS on internet gaming disorder: A randomized double-blind sham-controlled trial

open access: yesBrain Stimulation
Background and objectives: Internet Gaming Disorder (IGD) is prevalent with limited treatment efficacy. Targeting reducing craving triggered by gaming cues is a critical therapeutic objective.
Yixuan Song   +12 more
doaj   +1 more source

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