Results 11 to 20 of about 3,098,024 (301)
Programmable biomaterials for dynamic and responsive drug delivery [PDF]
, 2016 Biomaterials are continually being designed that enable new methods for interacting dynamically with cell and tissues, in turn unlocking new capabilities in areas ranging from drug delivery to regenerative medicine. In this review, we explore some of the
Almquist, BD, Kiani, MT, Stejskalova, A
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Virtual chemical reactions for drug design [PDF]
, 2009 Two methods for the fast, fragment-based combinatorial molecule assembly were developed. The software COLIBREE® (Combinatorial Library Breeding) generates candidate structures from scratch, based on stochastic optimization [1].
E Proschak +8 more
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Cancer Cell International, 2019 Background DKK1 has been reported to act as a tumor suppressor in breast cancer. However, the mechanism of DKK1 inhibits breast cancer migration and invasion was still unclear.
Jie Niu +9 more
doaj +1 more source
Alzheimer’s Research & Therapy, 2020 Background Amyloid β (Aβ)-directed immunotherapy has shown promising results in preclinical and early clinical Alzheimer’s disease (AD) trials, but successful translation to late clinics has failed so far.
Kathrin Gnoth +16 more
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Blood–brain barrier penetration prediction enhanced by uncertainty estimation
Journal of Cheminformatics, 2022 Blood–brain barrier is a pivotal factor to be considered in the process of central nervous system (CNS) drug development, and it is of great significance to rapidly explore the blood–brain barrier permeability (BBBp) of compounds in silico in early drug ...
Xiaochu Tong +11 more
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Identifying and preventing health problems among young drug-misusing offenders [PDF]
, 2013 Purpose – The purpose of this paper is to identify the health problems and treatment needs of drug-misusing offenders and to draw out the implications of the findings for health education and prevention.
Judith Aldridge +2 more
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Molecules, 2021 Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity.
Ruben Soto-Acosta +5 more
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Journal of Cheminformatics, 2023 Lipophilicity is a fundamental physical property that significantly affects various aspects of drug behavior, including solubility, permeability, metabolism, distribution, protein binding, and toxicity.
Yitian Wang +13 more
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Enhanced Remdesivir Analogues to Target SARS-CoV-2
Molecules, 2023 We report the short synthesis of novel C-nucleoside Remdesivir analogues, their cytotoxicity and an in vitro evaluation against SARS-CoV-2 (CoV2). The described compounds are nucleoside analogues bearing a nitrogen heterocycle as purine analogues.
Ryuichi Majima +4 more
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Nature Communications, 2023 Interest in macrocycles as potential therapeutic agents has increased rapidly. Macrocyclization of bioactive acyclic molecules provides a potential avenue to yield novel chemical scaffolds, which can contribute to the improvement of the biological ...
Yanyan Diao +15 more
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