Results 21 to 30 of about 1,782,190 (315)
Targeted protein degradation and multicomponent reactions in drug discovery [PDF]
, 2022 Multicomponent reaction (MCR) chemistry is a promising and useful tool for building the chemical library in a manner of high-efficiency, low-cost and mild conditions. Targeted protein degradation (TPD) as a hopeful technology has attracted much attention
Wang, Zefeng
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Multicomponent reactions, applications in medicinal chemistry & new modalities in drug discovery [PDF]
, 2020 The aim of this dissertation is to discuss new targets, to apply multicomponent reaction chemistry on scaffolds significant for medicinal chemistry applications and to implement new modalities in drug design and medicinal chemistry.
Konstantinidou, Markella
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AI-based disease risk score for community-acquired pneumonia hospitalization
iScience, 2023 Summary: Community-acquired pneumonia (CAP) is an acute infection involving the parenchyma of the lungs, which is acquired outside of the hospital. Population-wide real-world data and artificial intelligence (AI) were used to develop a disease risk score
Saeed Shakibfar +2 more
doaj +1 more source
, 2020 Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues
Beloqui Garcia, Ana +7 more
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, 2021 Low aqueous solubility and poor oral bioavailability are limiting factors in the oral delivery of voxelotor, an antisickling agent. To overcome these limitations, a voxelotor self-nanoemulsifying drug delivery system was developed.
Mbinze, Jérémie K +13 more
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Cell & Bioscience, 2023 Background Sleep disorders (SDs) are a symptom of the prodromal phase of neurodegenerative disorders that are mechanistically linked to the protein α-synuclein (α-syn) including Parkinson’s disease (PD).
Altair Brito Dos Santos +7 more
doaj +1 more source
Modular assembly of indole alkaloids enabled by multicomponent reaction
Nature Communications, 2023 Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in pharmaceuticals. Although methods for the synthesis of indole alkaloids are constantly explored, the direct single-step synthesis of these chemical entities ...
Jiaming Li +4 more
doaj +1 more source
Exploring Polypharmacology in Drug Design
, 2018 Nowadays it is widely accepted that one compound can be able to hit several targets at once. This “magic shotgun” approach for drug development properly describes the mechanism of biomolecular recognition.
Eriksson, Leif A, +4 more
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Uncovering New Drug Properties in Target-Based Drug–Drug Similarity Networks
, 2020 Despite recent advances in bioinformatics, systems biology, and machine learning, the accurate prediction of drug properties remains an open problem. Indeed, because the biological environment is a complex system, the traditional approach—based on ...
Mihai Udrescu +6 more
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Acta Pharmaceutica Sinica B, 2022 Current drugs for treating human cytomegalovirus (HCMV) infections are limited by resistance and treatment-associated toxicities. In developing mechanistically novel HCMV antivirals, we discovered an N-benzyl hydroxypyridone carboxamide antiviral hit (8a)
Sameera Senaweera +7 more
doaj +1 more source