Results 221 to 230 of about 17,208,238 (361)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Preparation of Lipophilic Derivatives of <i>para</i>-Aminosalicylic Acid for Antimicrobial Drug Design. [PDF]

ACS Omega
Hearn MJ, Min AK.
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Manifold-constrained nucleus-level denoising diffusion model for structure-based drug design. [PDF]

Proc Natl Acad Sci U S A
Liu S, Yan L, Du W, Liu W, Li Z, Guo H, Borgs C, Chayes J, Anandkumar A.   +8 more
europepmc   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Generative Deep Learning for de Novo Drug Design─A Chemical Space Odyssey. [PDF]

J Chem Inf Model
Özçelik R, Brinkmann H, Criscuolo E, Grisoni F.   +3 more
europepmc   +1 more source

The Drug Design and Discovery of Novel Enaminone Derivatives as Potential Anti-seizure Agents

Patrice L. Ayotunde, Rhashanda D. Haywood, Miguel Martin‐Caraballo   +2 more
openalex   +1 more source

Interactions between polyoxometalates and biological systems: from drug design to artificial enzymes

, 2018
Laura S. Van Rompuy, Tatjana N. Parac‐Vogt   +1 more
openalex   +2 more sources